Detalhe da pesquisa
1.
Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGFßRI).
Bioorg Med Chem
; 26(5): 1026-1034, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29422332
2.
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia.
Nature
; 458(7239): 776-9, 2009 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-19169242
3.
ß-Arrestin2 mediates the initiation and progression of myeloid leukemia.
Proc Natl Acad Sci U S A
; 109(31): 12532-7, 2012 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-22773819
4.
DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity.
J Immunother Cancer
; 10(6)2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35688554
5.
Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization.
J Med Chem
; 65(4): 3518-3538, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35108011
6.
Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors.
Cancer Discov
; 12(5): 1248-1265, 2022 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35176764
7.
Discovery of Imidazopyridines as Potent Inhibitors of Indoleamine 2,3-Dioxygenase 1 for Cancer Immunotherapy.
ACS Med Chem Lett
; 12(3): 494-501, 2021 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33738077
8.
Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1.
ACS Med Chem Lett
; 12(2): 288-294, 2021 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33603977
9.
Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors.
ACS Med Chem Lett
; 12(7): 1143-1150, 2021 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34267885
10.
Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFßR1 Inhibitor as an Immuno-oncology Agent.
ACS Med Chem Lett
; 11(2): 172-178, 2020 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32071685
11.
Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis.
ACS Med Chem Lett
; 11(7): 1402-1409, 2020 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32676146
12.
Epidermal growth factor receptor tyrosine phosphorylation and signaling controlled by a nuclear receptor coactivator, amplified in breast cancer 1.
Cancer Res
; 67(15): 7256-65, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17671194
13.
Critical role of kinase activity of hematopoietic progenitor kinase 1 in anti-tumor immune surveillance.
PLoS One
; 14(3): e0212670, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30913212
14.
Miniaturized High-Throughput Multiparameter Flow Cytometry Assays Measuring In Vitro Human Dendritic Cell Maturation and T-Cell Activation in Mixed Lymphocyte Reactions.
SLAS Discov
; 23(7): 742-750, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29873570
15.
Discovery of 4-Azaindole Inhibitors of TGFßRI as Immuno-oncology Agents.
ACS Med Chem Lett
; 9(11): 1117-1122, 2018 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30429955
16.
Antroquinonol A: Scalable Synthesis and Preclinical Biology of a Phase 2 Drug Candidate.
ACS Cent Sci
; 2(1): 27-31, 2016 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27163023
17.
Development of a Human Whole Blood Screening Platform to Monitor JAK/STAT Signaling Using High-Throughput Flow Cytometry.
J Biomol Screen
; 21(8): 866-74, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27142718
18.
Targeted disruption of ß-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth.
PLoS One
; 9(4): e93441, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24736311
19.
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth.
Cancer Cell
; 17(4): 388-99, 2010 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-20385363
20.
The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice.
Cancer Res
; 68(10): 3697-706, 2008 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18483252