Pesquisa | BVS IEC

1.

Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development.

Donovan, Katherine A; Ferguson, Fleur M; Bushman, Jonathan W; Eleuteri, Nicholas A; Bhunia, Debabrata; Ryu, SeongShick; Tan, Li; Shi, Kun; Yue, Hong; Liu, Xiaoxi; Dobrovolsky, Dennis; Jiang, Baishan; Wang, Jinhua; Hao, Mingfeng; You, Inchul; Teng, Mingxing; Liang, Yanke; Hatcher, John; Li, Zhengnian; Manz, Theresa D; Groendyke, Brian; Hu, Wanyi; Nam, Yunju; Sengupta, Sandip; Cho, Hanna; Shin, Injae; Agius, Michael P; Ghobrial, Irene M; Ma, Michelle W; Che, Jianwei; Buhrlage, Sara J; Sim, Taebo; Gray, Nathanael S; Fischer, Eric S.

Cell ; 183(6): 1714-1731.e10, 2020 12 10.

Artigo em Inglês | MEDLINE | ID: mdl-33275901

2.

Measuring Ligand-bound Protein Complexes with Proximity Labeling: A Practical Guide.

Goyal, Pavitra; Tao, Andrew J; Mumby, Elizabeth J; English, Justin G; Ferguson, Fleur M.

Chembiochem ; : e202400073, 2024 Mar 08.

Artigo em Inglês | MEDLINE | ID: mdl-38457625

3.

Discovery of a selective inhibitor of doublecortin like kinase 1.

Ferguson, Fleur M; Nabet, Behnam; Raghavan, Srivatsan; Liu, Yan; Leggett, Alan L; Kuljanin, Miljan; Kalekar, Radha L; Yang, Annan; He, Shuning; Wang, Jinhua; Ng, Raymond W S; Sulahian, Rita; Li, Lianbo; Poulin, Emily J; Huang, Ling; Koren, Jost; Dieguez-Martinez, Nora; Espinosa, Sergio; Zeng, Zhiyang; Corona, Cesear R; Vasta, James D; Ohi, Ryoma; Sim, Taebo; Kim, Nam Doo; Harshbarger, Wayne; Lizcano, Jose M; Robers, Matthew B; Muthaswamy, Senthil; Lin, Charles Y; Look, A Thomas; Haigis, Kevin M; Mancias, Joseph D; Wolpin, Brian M; Aguirre, Andrew J; Hahn, William C; Westover, Kenneth D; Gray, Nathanael S.

Nat Chem Biol ; 16(6): 635-643, 2020 06.

Artigo em Inglês | MEDLINE | ID: mdl-32251410

4.

Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells.

Carli, Annalisa L E; Afshar-Sterle, Shoukat; Rai, Alin; Fang, Haoyun; O'Keefe, Ryan; Tse, Janson; Ferguson, Fleur M; Gray, Nathanael S; Ernst, Matthias; Greening, David W; Buchert, Michael.

Proteomics ; 21(13-14): e2000098, 2021 07.

Artigo em Inglês | MEDLINE | ID: mdl-33991177

5.

Tuned out.

Ferguson, Fleur M.

Nat Chem Biol ; 18(9): 917-918, 2022 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-35590002

6.

Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14.

Ferguson, Fleur M; Doctor, Zainab M; Ficarro, Scott B; Marto, Jarrod A; Kim, Nam Doo; Sim, Taebo; Gray, Nathanael S.

Bioorg Med Chem Lett ; 29(15): 1985-1993, 2019 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-31175010

7.

Characterization of a highly selective inhibitor of the Aurora kinases.

Ferguson, Fleur M; Doctor, Zainab M; Chaikuad, Apirat; Sim, Taebo; Kim, Nam Doo; Knapp, Stefan; Gray, Nathanael S.

Bioorg Med Chem Lett ; 27(18): 4405-4408, 2017 09 15.

Artigo em Inglês | MEDLINE | ID: mdl-28818446

8.

Assembling a Robust Workflow for Characterizing Endogenous E3 Ligase Substrates.

Tao, Andrew J; Ferguson, Fleur M.

Biochemistry ; 60(31): 2365-2366, 2021 08 10.

Artigo em Inglês | MEDLINE | ID: mdl-34077180

9.

Binding hotspots of BAZ2B bromodomain: Histone interaction revealed by solution NMR driven docking.

Ferguson, Fleur M; Dias, David M; Rodrigues, João P G L M; Wienk, Hans; Boelens, Rolf; Bonvin, Alexandre M J J; Abell, Chris; Ciulli, Alessio.

Biochemistry ; 53(42): 6706-16, 2014 Oct 28.

Artigo em Inglês | MEDLINE | ID: mdl-25266743

10.

A new avenue for molecular glues: Rapid discovery of a NFKB1 degrader.

Fan, Angela T; Boyle, Bridget T; Ferguson, Fleur M.

Cell Chem Biol ; 30(4): 340-342, 2023 04 20.

Artigo em Inglês | MEDLINE | ID: mdl-37084716

11.

A biotin targeting chimera (BioTAC) system to map small molecule interactomes in situ.

Tao, Andrew J; Jiang, Jiewei; Gadbois, Gillian E; Goyal, Pavitra; Boyle, Bridget T; Mumby, Elizabeth J; Myers, Samuel A; English, Justin G; Ferguson, Fleur M.

Nat Commun ; 14(1): 8016, 2023 Dec 04.

Artigo em Inglês | MEDLINE | ID: mdl-38049406

12.

A Biotin Targeting Chimera (BioTAC) System to Map Small Molecule Interactomes in situ.

Tao, Andrew J; Jiang, Jiewei; Gadbois, Gillian E; Goyal, Pavitra; Boyle, Bridget T; Mumby, Elizabeth J; Myers, Samuel A; English, Justin G; Ferguson, Fleur M.

bioRxiv ; 2023 Aug 22.

Artigo em Inglês | MEDLINE | ID: mdl-37662262

13.

Targeted Protein Degradation: Design Considerations for PROTAC Development.

Tran, Nathan L; Leconte, Georges A; Ferguson, Fleur M.

Curr Protoc ; 2(12): e611, 2022 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-36469581

14.

Targeted protein degradation: Emerging concepts and protein state-specific targeting principles.

Tao, Andrew J; Gadbois, Gillian E; Buczynski, Stanley A; Ferguson, Fleur M.

Curr Opin Chem Biol ; 67: 102114, 2022 04.

Artigo em Inglês | MEDLINE | ID: mdl-35042023

15.

Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy.

Silva, M Catarina; Nandi, Ghata; Donovan, Katherine A; Cai, Quan; Berry, Bethany C; Nowak, Radoslaw P; Fischer, Eric S; Gray, Nathanael S; Ferguson, Fleur M; Haggarty, Stephen J.

Front Cell Neurosci ; 16: 801179, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35317195

16.

Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma.

Jiang, Baishan; Jiang, Jie; Kaltheuner, Ines H; Iniguez, Amanda Balboni; Anand, Kanchan; Ferguson, Fleur M; Ficarro, Scott B; Seong, Bo Kyung Alex; Greifenberg, Ann Katrin; Dust, Sofia; Kwiatkowski, Nicholas P; Marto, Jarrod A; Stegmaier, Kimberly; Zhang, Tinghu; Geyer, Matthias; Gray, Nathanael S.

Eur J Med Chem ; 221: 113481, 2021 Oct 05.

Artigo em Inglês | MEDLINE | ID: mdl-33945934

17.

TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma.

Seong, Bo Kyung A; Dharia, Neekesh V; Lin, Shan; Donovan, Katherine A; Chong, Shasha; Robichaud, Amanda; Conway, Amy; Hamze, Amanda; Ross, Linda; Alexe, Gabriela; Adane, Biniam; Nabet, Behnam; Ferguson, Fleur M; Stolte, Björn; Wang, Emily Jue; Sun, Jialin; Darzacq, Xavier; Piccioni, Federica; Gray, Nathanael S; Fischer, Eric S; Stegmaier, Kimberly.

Cancer Cell ; 39(9): 1262-1278.e7, 2021 09 13.

Artigo em Inglês | MEDLINE | ID: mdl-34329586

18.

Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one Scaffold.

Ferguson, Fleur M; Liu, Yan; Harshbarger, Wayne; Huang, Ling; Wang, Jinhua; Deng, Xianming; Capuzzi, Stephen J; Muratov, Eugene N; Tropsha, Alexander; Muthuswamy, Senthil; Westover, Kenneth D; Gray, Nathanael S.

J Med Chem ; 63(14): 7817-7826, 2020 07 23.

Artigo em Inglês | MEDLINE | ID: mdl-32530623

19.

Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing.

Liu, Yan; Ferguson, Fleur M; Li, Lianbo; Kuljanin, Miljan; Mills, Caitlin E; Subramanian, Kartik; Harshbarger, Wayne; Gondi, Sudershan; Wang, Jinhua; Sorger, Peter K; Mancias, Joseph D; Gray, Nathanael S; Westover, Kenneth D.

Cell Chem Biol ; 27(10): 1229-1240.e4, 2020 10 15.

Artigo em Inglês | MEDLINE | ID: mdl-32755567

20.

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules.

Nabet, Behnam; Ferguson, Fleur M; Seong, Bo Kyung A; Kuljanin, Miljan; Leggett, Alan L; Mohardt, Mikaela L; Robichaud, Amanda; Conway, Amy S; Buckley, Dennis L; Mancias, Joseph D; Bradner, James E; Stegmaier, Kimberly; Gray, Nathanael S.

Nat Commun ; 11(1): 4687, 2020 09 18.

Artigo em Inglês | MEDLINE | ID: mdl-32948771

BVS IEC

Instituto Evandro Chagas

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