Detalhe da pesquisa
1.
Predicted deleterious variants in ABCA1, LPL, LPA and KIF6 are associated with statin response and adverse events in patients with familial hypercholesterolemia and disturb protein structure and stability.
Pharmacogenet Genomics
; 34(4): 91-104, 2024 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38682317
2.
Innovative Microemulsion Loaded with Unusual Dimeric Flavonoids from Fridericia platyphylla (Cham.) L.G. Lohmann Roots.
AAPS PharmSciTech
; 24(8): 212, 2023 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37848719
3.
Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase.
J Am Chem Soc
; 144(12): 5629-5642, 2022 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-35293728
4.
Do Go Chasing Waterfalls: Enoyl Reductase (FabI) in Complex with Inhibitors Stabilizes the Tetrameric Structure and Opens Water Channels.
J Chem Inf Model
; 62(22): 5746-5761, 2022 11 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36343333
5.
Design, synthesis and biological activity of novel substituted 3-benzoic acid derivatives as MtDHFR inhibitors.
Bioorg Med Chem
; 28(15): 115600, 2020 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32631571
6.
Inhibition of Porcine Aminopeptidase M (pAMP) by the Pentapeptide Microginins.
Molecules
; 24(23)2019 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-31795383
7.
Correction to "Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase".
J Am Chem Soc
; 145(17): 9895-9896, 2023 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37075548
8.
Correction to: Innovative Microemulsion Loaded with Unusual Dimeric Flavonoids from Fridericia platyphylla (Cham.) L.G. Lohmann Roots.
AAPS PharmSciTech
; 24(8): 227, 2023 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37964166
9.
Identification, In Vitro Testing and Molecular Docking Studies of Microginins' Mechanism of Angiotensin-Converting Enzyme Inhibition.
Molecules
; 22(12)2017 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29206156
10.
Exploring the conformational dynamics of the CRD4: a model for receptor lysosomal activity shifts in search of 'sweet' and 'sour' states.
J Biomol Struct Dyn
; : 1-7, 2023 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37440242
11.
Covalent Inhibitors for Neglected Diseases: An Exploration of Novel Therapeutic Options.
Pharmaceuticals (Basel)
; 16(7)2023 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37513939
12.
Dynamics of the personalities of PCSK9 on missense variants (rs505151 and rs562556) from elderly cohort studies in Brazil.
J Biomol Struct Dyn
; 41(24): 15625-15633, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37010997
13.
Exploring the dark side of tertiary and quaternary structure dynamics in MtbFBPaseII.
J Biomol Struct Dyn
; : 1-9, 2023 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37837432
14.
Trypanosoma cruzi Sirtuin 2 as a Relevant Druggable Target: New Inhibitors Developed by Computer-Aided Drug Design.
Pharmaceuticals (Basel)
; 16(3)2023 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36986527
15.
Effects of PCSK9 missense variants on molecular conformation and biological activity in transfected HEK293FT cells.
Gene
; 851: 146979, 2023 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36261084
16.
LDLR missense variants disturb structural conformation and LDLR activity in T-lymphocytes of Familial hypercholesterolemia patients.
Gene
; 853: 147084, 2023 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36464169
17.
Identification of pathogenic variants in the Brazilian cohort with Familial hypercholesterolemia using exon-targeted gene sequencing.
Gene
; 875: 147501, 2023 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37217153
18.
Inhibitor induced conformational changes in SARS-COV-2 papain-like protease.
Sci Rep
; 12(1): 11585, 2022 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35803957
19.
Zika Virus NS2B-NS3 Protease: Quantum Chemical Properties Insights into Designing Inhibitory Peptides.
Protein Pept Lett
; 29(11): 901-910, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36121092
20.
SARS-COV-2 Mpro conformational changes induced by covalently bound ligands.
J Biomol Struct Dyn
; 40(22): 12347-12357, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-34516349