Detalhe da pesquisa
1.
TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks.
Mol Cell
; 51(6): 829-39, 2013 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24035500
2.
Kendomycin Cytotoxicity against Bacterial, Fungal, and Mammalian Cells Is Due to Cation Chelation.
J Nat Prod
; 83(4): 965-971, 2020 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32182062
3.
Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae.
J Biol Chem
; 293(31): 12043-12053, 2018 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29895620
4.
Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import.
Nat Chem Biol
; 13(12): 1239-1244, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28991239
5.
High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines.
PLoS Genet
; 12(11): e1006374, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27855158
6.
Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways.
J Biol Chem
; 290(24): 14963-78, 2015 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25882841
7.
Multiple Genes Core to ERAD, Macroautophagy and Lysosomal Degradation Pathways Participate in the Proteostasis Response in α1-Antitrypsin Deficiency.
Cell Mol Gastroenterol Hepatol
; 17(6): 1007-1024, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38336172
8.
Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties.
Cell Chem Biol
; 25(3): 279-290.e7, 2018 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29307839
9.
Direct Interaction of Chivosazole F with Actin Elicits Cell Responses Similar to Latrunculin A but Distinct from Chondramide.
ACS Chem Biol
; 12(9): 2264-2269, 2017 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28796488
10.
The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase.
Cell Rep
; 19(3): 451-460, 2017 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28423309
11.
Advantages and Challenges of Phenotypic Screens: The Identification of Two Novel Antifungal Geranylgeranyltransferase I Inhibitors.
J Biomol Screen
; 21(3): 306-15, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26459507
12.
FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p.
Nat Commun
; 6: 8613, 2015 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26456460
13.
SpeedScreen: The "missing link" between genomics and lead discovery.
J Biomol Screen
; 9(6): 498-505, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15452336
14.
Development and implementation of a highly miniaturized confocal 2D-FIDA-based high-throughput screening assay to search for active site modulators of the human heat shock protein 90beta.
J Biomol Screen
; 9(7): 569-77, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15475476
15.
High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions.
Microbiol Res
; 169(2-3): 107-20, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24360837
16.
Synthesis and characterization of fluorescent ubiquitin derivatives as highly sensitive substrates for the deubiquitinating enzymes UCH-L3 and USP-2.
Anal Biochem
; 343(2): 244-55, 2005 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15963938
17.
Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha.
J Biol Chem
; 279(47): 49330-7, 2004 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-15337744