Detalhe da pesquisa
1.
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy.
Nature
; 615(7953): 668-677, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36890231
2.
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
Nature
; 549(7673): 523-527, 2017 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28959956
3.
Obstructive sleep apnea treatment, slow wave activity, and amyloid-ß.
Ann Neurol
; 85(2): 291-295, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30597615
4.
Obstructive sleep apnea decreases central nervous system-derived proteins in the cerebrospinal fluid.
Ann Neurol
; 80(1): 154-9, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27129429
5.
Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death.
Proc Natl Acad Sci U S A
; 108(47): 19054-9, 2011 Nov 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22058226
6.
Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid ß peptide.
J Neurosci
; 32(43): 15181-92, 2012 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23100439
7.
In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice.
J Neurosci
; 31(37): 13110-7, 2011 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21917794
8.
Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-ß amyloidosis.
J Neurosci
; 31(49): 18007-12, 2011 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-22159114
9.
apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain.
J Clin Invest
; 118(12): 4002-13, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19033669
10.
Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.
Neuron
; 48(6): 913-22, 2005 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-16364896
11.
Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice.
J Neurosci
; 28(52): 14156-64, 2008 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19109498
12.
Lack of hepatic apoE does not influence early Aß deposition: observations from a new APOE knock-in model.
Mol Neurodegener
; 14(1): 37, 2019 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31623648
13.
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans.
Science
; 363(6429): 880-884, 2019 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30679382
14.
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model.
J Clin Invest
; 115(11): 3285-90, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16239972
15.
Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.
J Clin Invest
; 128(5): 2144-2155, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29600961
16.
Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of ß-amyloidosis.
Neuron
; 96(5): 1013-1023.e4, 2017 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29216448
17.
Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy.
Sci Transl Med
; 9(386)2017 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28424326
18.
Altered microglial response to Aß plaques in APPPS1-21 mice heterozygous for TREM2.
Mol Neurodegener
; 9: 20, 2014 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24893973
19.
Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease.
J Exp Med
; 211(13): 2487-96, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25422493
20.
Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease.
Neurobiol Dis
; 24(3): 506-15, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17010630