Detalhe da pesquisa
1.
The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation.
EMBO J
; 40(10): e106503, 2021 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33934390
2.
Combinatorial targeting of G-protein-coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug-induced liver injury.
Hepatology
; 78(1): 26-44, 2023 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36107019
3.
Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists.
Molecules
; 28(6)2023 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36985811
4.
Discovery of Bile Acid Derivatives as Potent ACE2 Activators by Virtual Screening and Essential Dynamics.
J Chem Inf Model
; 62(1): 196-209, 2022 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34914393
5.
Molecular Basis for Non-Covalent, Non-Competitive FAAH Inhibition.
Int J Mol Sci
; 23(24)2022 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36555144
6.
Structural insights into the unexpected agonism of tetracyclic antidepressants at serotonin receptors 5-HT1eR and 5-HT1FR.
Sci Adv
; 10(16): eadk4855, 2024 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38630816
7.
Development of bile acid activated receptors hybrid molecules for the treatment of inflammatory and metabolic disorders.
Biochem Pharmacol
; 216: 115776, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37659739
8.
Structural Insights into the Unexpected Agonism of Tetracyclic Antidepressants at Serotonin Receptors 5-HT1eR and 5-HT1FR.
bioRxiv
; 2023 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37986777
9.
Discovery of a Novel Class of Dual GPBAR1 Agonists-RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders.
ACS Omega
; 8(6): 5983-5994, 2023 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36816679
10.
Correction to "Discovery of a Novel Class of Dual GPBAR1 Agonists-RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders".
ACS Omega
; 8(47): 45163, 2023 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38046314
11.
Metadynamics simulations leveraged by statistical analyses and artificial intelligence-based tools to inform the discovery of G protein-coupled receptor ligands.
Front Endocrinol (Lausanne)
; 13: 1099715, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36619585
12.
Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease.
Front Pharmacol
; 13: 858137, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35559268
13.
Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction.
Biochem Pharmacol
; 188: 114564, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33872570
14.
Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1.
J Med Chem
; 64(22): 16512-16529, 2021 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34767347
15.
Hijacking SARS-CoV-2/ACE2 Receptor Interaction by Natural and Semi-synthetic Steroidal Agents Acting on Functional Pockets on the Receptor Binding Domain.
Front Chem
; 8: 572885, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33195060