Detalhe da pesquisa
1.
Exploitation of structural and regulatory diversity in glutamate racemases.
Nature
; 447(7146): 817-22, 2007 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17568739
2.
Bivalent Ligands for Protein Degradation in Drug Discovery.
Comput Struct Biotechnol J
; 17: 160-176, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30788082
3.
Novel prostaglandin D synthase inhibitors generated by fragment-based drug design.
J Med Chem
; 51(7): 2178-86, 2008 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18341273
4.
Drug target residence time: a misleading concept.
Drug Discov Today
; 23(1): 12-16, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28782685
5.
Discovery of a novel warhead against beta-secretase through fragment-based lead generation.
J Med Chem
; 50(24): 5903-11, 2007 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-17985861
6.
Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency.
J Med Chem
; 50(24): 5912-25, 2007 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-17985862
7.
Unified Software Solution for Efficient SPR Data Analysis in Drug Research.
SLAS Discov
; 22(2): 203-209, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27789754
8.
IMI European Lead Factory - democratizing access to high-throughput screening.
Nat Rev Drug Discov
; 21(4): 245-246, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34907316
9.
Integrating biophysics with HTS-driven drug discovery projects.
Drug Discov Today
; 21(3): 491-8, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26826422
10.
An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.
Curr Top Med Chem
; 7(16): 1600-29, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17979771
11.
Fragment screening to predict druggability (ligandability) and lead discovery success.
Drug Discov Today
; 16(7-8): 284-7, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21315179
12.
Interaction of the replication terminator protein of Bacillus subtilis with DNA probed by NMR spectroscopy.
Biochem Biophys Res Commun
; 335(2): 361-6, 2005 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-16061201
13.
Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: two bikes rather than a tandem.
Biochemistry
; 41(48): 14176-84, 2002 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-12450381