Detalhe da pesquisa
1.
Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.
Proc Natl Acad Sci U S A
; 118(3)2021 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33446504
2.
Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence-based affinity maturation.
J Biol Chem
; 298(2): 101533, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34973336
3.
Native SEC and Reversed-Phase LC-MS Reveal Impact of Fab Glycosylation of Anti-SARS-COV-2 Antibodies on Binding to the Receptor Binding Domain.
Anal Chem
; 95(42): 15477-15485, 2023 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37812809
4.
The serum protein transthyretin as a platform for dimerization and tetramerization of antibodies and Fab fragments to enable target clustering.
J Biol Chem
; 295(30): 10446-10455, 2020 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32518163
5.
Discovery and bio-optimization of human antibody therapeutics using the XenoMouse® transgenic mouse platform.
Immunol Rev
; 270(1): 51-64, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26864104
6.
TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function.
J Biol Chem
; 293(32): 12620-12633, 2018 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29599291
7.
Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
J Biol Chem
; 293(32): 12634-12646, 2018 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29794134
8.
Functional and Nonclinical Similarity of ABP 980, a Biosimilar of Trastuzumab.
Pharm Res
; 36(12): 177, 2019 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31696314
9.
Impact of antibody subclass and disulfide isoform differences on the biological activity of CD200R and ßklotho agonist antibodies.
Biochem Biophys Res Commun
; 486(4): 985-991, 2017 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28363871
10.
A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism.
J Biol Chem
; 290(12): 7535-62, 2015 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25583986
11.
Analytical and Functional Similarity of Aflibercept Biosimilar ABP 938 with Aflibercept Reference Product.
Ophthalmol Ther
; 13(5): 1303-1320, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38507189
12.
Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG.
J Biol Chem
; 285(25): 19637-46, 2010 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20400508
13.
Kinetic analysis of unpurified native antigens available in very low quantities and concentrations.
Anal Biochem
; 414(1): 7-13, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21371417
14.
Evolution and emergence of therapeutic monoclonal antibodies: what cardiologists need to know.
Circulation
; 127(22): 2222-30, 2013 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-23733968
15.
Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models.
Sci Transl Med
; 10(472)2018 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30567927
16.
AMG 595, an Anti-EGFRvIII Antibody-Drug Conjugate, Induces Potent Antitumor Activity against EGFRvIII-Expressing Glioblastoma.
Mol Cancer Ther
; 14(7): 1614-24, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25931519
17.
Identification and Characterization of MEDI4736, an Antagonistic Anti-PD-L1 Monoclonal Antibody.
Cancer Immunol Res
; 3(9): 1052-62, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25943534
18.
Apo2L/TRAIL and the death receptor 5 agonist antibody AMG 655 cooperate to promote receptor clustering and antitumor activity.
Cancer Cell
; 26(2): 177-89, 2014 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25043603
19.
MEDI0639: a novel therapeutic antibody targeting Dll4 modulates endothelial cell function and angiogenesis in vivo.
Mol Cancer Ther
; 11(8): 1650-60, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22679110
20.
Treating diabetes and obesity with an FGF21-mimetic antibody activating the ßKlotho/FGFR1c receptor complex.
Sci Transl Med
; 4(162): 162ra153, 2012 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23197570