Detalhe da pesquisa
1.
Locus Coeruleus and Noradrenergic Pharmacology in Neurodegenerative Disease.
Handb Exp Pharmacol
; 2023 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37495851
2.
Gefapixant in two randomised dose-escalation studies in chronic cough.
Eur Respir J
; 55(3)2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31949115
3.
The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: a randomised placebo-controlled study.
Eur Respir J
; 54(1)2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31023843
4.
Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: Role of adenosine triphosphate.
J Allergy Clin Immunol
; 138(1): 249-261.e12, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26792207
5.
P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study.
Lancet
; 385(9974): 1198-205, 2015 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25467586
6.
Postsynaptic P2X3-containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice.
J Physiol
; 593(5): 1113-25, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25524179
7.
Author response: The human cough reflex has separate, distinct pathways.
Eur Respir J
; 55(2)2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32029646
8.
Inhibition of urothelial P2X3 receptors prevents desensitization of purinergic detrusor contractions in the rat bladder.
BJU Int
; 116(2): 293-301, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25430615
9.
Single- and Multiple-Dose Pharmacokinetics of Gefapixant (MK-7264), a P2X3 Receptor Antagonist, in Healthy Adults.
J Clin Pharmacol
; 2024 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38651193
10.
Fingerprinting heterocellular ß-adrenoceptor functional expression in the brain using agonist activity profiles.
Front Mol Biosci
; 10: 1214102, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37664183
11.
P2X3 receptor antagonism attenuates the progression of heart failure.
Nat Commun
; 14(1): 1725, 2023 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36977675
12.
A role for ATP in bronchoconstriction-induced activation of guinea pig vagal intrapulmonary C-fibres.
J Physiol
; 590(16): 4109-20, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22687618
13.
Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3 receptors.
BJU Int
; 110(8 Pt B): E409-14, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22540742
14.
In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization.
Purinergic Signal
; 8(Suppl 1): 3-26, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22095157
15.
Clinical Formulation Bridging of Gefapixant, a P2X3-Receptor Antagonist, for the Treatment of Chronic Cough.
Clin Pharmacol Drug Dev
; 11(9): 1054-1067, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35510785
16.
Endogenous purinergic control of bladder activity via presynaptic P2X3 and P2X2/3 receptors in the spinal cord.
J Neurosci
; 30(12): 4503-7, 2010 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-20335487
17.
P2X3 receptor antagonist in chronic cough--Authors' reply.
Lancet
; 386(9990): 244-5, 2015 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26194520
18.
Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats.
Brain
; 133(9): 2549-64, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20802203
19.
ATP and P2X purinoceptors in urinary tract disorders.
Handb Exp Pharmacol
; (202): 485-526, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21290240
20.
The discovery and development of gefapixant.
Auton Neurosci
; 235: 102859, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34403981