Detalhe da pesquisa
1.
Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors.
Bioorg Med Chem Lett
; 26(17): 4250-5, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27476420
2.
Initial optimization and series evolution of diaminopyrimidine inhibitors of interleukin-1 receptor associated kinase 4.
Bioorg Med Chem Lett
; 25(16): 3203-7, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26115573
3.
Discovery of a novel series of potent MK2 non-ATP competitive inhibitors using 1,2-substituted azoles as cis-amide isosteres.
Bioorg Med Chem Lett
; 24(15): 3609-13, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24913714
4.
Conformation constraint of anilides enabling the discovery of tricyclic lactams as potent MK2 non-ATP competitive inhibitors.
Bioorg Med Chem Lett
; 23(11): 3262-6, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23602398
5.
Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors.
Bioorg Med Chem Lett
; 22(2): 1068-72, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22182499
6.
A three-step protocol for lead optimization: quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors.
Bioorg Med Chem Lett
; 22(1): 65-70, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22169260
7.
3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists.
Bioorg Med Chem Lett
; 19(5): 1434-7, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19200721
8.
3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists.
Bioorg Med Chem Lett
; 18(1): 228-31, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18006311
9.
Synthesis and structure-activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists.
Bioorg Med Chem Lett
; 18(4): 1318-22, 2008 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18242983
10.
A High-Throughput Time-Resolved Fluorescence Energy Transfer Assay to Screen for Modulators of RGS7/Gß5/R7BP Complex.
Assay Drug Dev Technol
; 16(3): 150-161, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29658790
11.
Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist.
J Med Chem
; 49(26): 7603-6, 2006 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17181143
12.
Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors.
ACS Med Chem Lett
; 6(8): 942-7, 2015 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26288698
13.
Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation.
ACS Med Chem Lett
; 6(6): 677-82, 2015 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26101573
14.
Pharmacological characterization of human S1P4 using a novel radioligand, [4,5-3H]-dihydrosphingosine-1-phosphate.
Br J Pharmacol
; 142(5): 851-60, 2004 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15197107
15.
Discovery of a Potent Dihydrooxadiazole Series of Non-ATP-Competitive MK2 (MAPKAPK2) Inhibitors.
ACS Med Chem Lett
; 3(2): 100-5, 2012 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900435
16.
Pharmacological characterization of Sch527123, a potent allosteric CXCR1/CXCR2 antagonist.
J Pharmacol Exp Ther
; 322(2): 477-85, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17496166
17.
Characterization of peripheral human cannabinoid receptor (hCB2) expression and pharmacology using a novel radioligand, [35S]Sch225336.
J Biol Chem
; 281(38): 28143-51, 2006 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-16754676
18.
Pharmacological analysis of calcium responses mediated by the human A3 adenosine receptor in monocyte-derived dendritic cells and recombinant cells.
Mol Pharmacol
; 63(2): 342-50, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12527805