RESUMO
AIM: To investigate mortality risk factors in patients with zygomycosis. PATIENTS AND METHODS: Retrospective case history review of patients diagnosed with proven zygomicosis in 17 centres in Spain. We compared demographics and risk factors in patients who survived, and in those who died. RESULTS: We identified twenty-five patients with proven zygomycosis. The primary site of infection was rhino-orbito-cerebral (28%) and disseminated (20%) or cutaneous/soft infections (20%) of the patients. Eleven patients (44%) received preemptive or empirical antifungal treatment; of these patients, 4 received liposomal amphotericin B, 1 received amphotericin B lipid complex, and 6 received other antifungals. The overall mortality rate was 72%. In the univariate analysis factors associated with an increased risk of death were the presence of a haematological malignancy (P=.03), neutropenia (P=.03) and monocytopenia (P=.008). CONCLUSION: Our study supports previous research that has documented a high mortality rate among patients with invasive zygomycosis, especially among those with an underlying haematological malignancy, and the need for a rapid initiation of an effective antifungal treatment.
Assuntos
Zigomicose/mortalidade , Adulto , Idoso , Antifúngicos/uso terapêutico , Infecções Fúngicas do Sistema Nervoso Central/tratamento farmacológico , Infecções Fúngicas do Sistema Nervoso Central/mortalidade , Terapia Combinada , Complicações do Diabetes/mortalidade , Feminino , Fungemia/tratamento farmacológico , Fungemia/mortalidade , Neoplasias Hematológicas/complicações , Neoplasias Hematológicas/epidemiologia , Humanos , Hospedeiro Imunocomprometido , Leucopenia/complicações , Leucopenia/epidemiologia , Masculino , Pessoa de Meia-Idade , Neutropenia/complicações , Neutropenia/epidemiologia , Infecções Oportunistas/tratamento farmacológico , Infecções Oportunistas/microbiologia , Infecções Oportunistas/mortalidade , Infecções Oportunistas/cirurgia , Estudos Retrospectivos , Fatores de Risco , Infecções dos Tecidos Moles/tratamento farmacológico , Infecções dos Tecidos Moles/mortalidade , Espanha/epidemiologia , Adulto Jovem , Zigomicose/tratamento farmacológico , Zigomicose/cirurgiaRESUMO
The maze test is a complex cognitive task involving visuoperceptual, planning and foresight abilities. EEGs were recorded from 20 healthy subjects according to the 10/20 system. Coherence is analogous to a correlation coefficient between the signals recorded by two electrodes and is computed between each electrode paired to all other electrodes. The maze test provoked changes of coherence mainly within the prefrontal regions, between parietal and central electrodes paired with frontal electrodes, especially the right frontopolar and the left prefrontal electrodes, and in the posterior temporal, parietal and occipital regions. EEG coherence analysis detects changes in regions known to be involved in visual processing and executive functions.