Detalhe da pesquisa
1.
Structural insights into the morpholino nucleic acid/RNA duplex using the new XNA builder Ducque in a molecular modeling pipeline.
Nucleic Acids Res
; 52(6): 2836-2847, 2024 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38412249
2.
Synthesis of a 3,7-Disubstituted Isothiazolo[4,3-b]pyridine as a Potential Inhibitor of Cyclin G-Associated Kinase.
Molecules
; 29(5)2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38474466
3.
Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins.
Nucleic Acids Res
; 47(13): 7130-7142, 2019 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31334814
4.
Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase.
Bioorg Med Chem
; 28(1): 115188, 2020 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31757682
5.
Quinolinecarboxamides Inhibit the Replication of the Bovine Viral Diarrhea Virus by Targeting a Hot Spot for the Inhibition of Pestivirus Replication in the RNA-Dependent RNA Polymerase.
Molecules
; 25(6)2020 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32178258
6.
Invading Escherichia coli Genetics with a Xenobiotic Nucleic Acid Carrying an Acyclic Phosphonate Backbone (ZNA).
J Am Chem Soc
; 141(27): 10844-10851, 2019 07 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31251601
7.
1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase.
J Enzyme Inhib Med Chem
; 34(1): 1730-1739, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31822127
8.
Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase.
J Virol
; 91(12)2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28381577
9.
Chimeric XNA: An Unconventional Design for Orthogonal Informational Systems.
Chemistry
; 24(49): 12811-12819, 2018 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29901248
10.
Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins.
Nucleic Acids Res
; 47(22): 11976-11977, 2019 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31713624
11.
Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.
Antimicrob Agents Chemother
; 59(12): 7782-5, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26369972
12.
1',5'-Anhydro-L-ribo-hexitol Adenine Nucleic Acids (α-L-HNA-A): Synthesis and Chiral Selection Properties in the Mirror Image World.
J Org Chem
; 80(10): 5014-22, 2015 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25853790
13.
Hybridisation potential of 1',3'-Di-O-methylaltropyranoside nucleic acids.
Molecules
; 20(3): 4020-41, 2015 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25741897
14.
The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication.
Antimicrob Agents Chemother
; 58(11): 6990-2, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25199773
15.
A novel benzonitrile analogue inhibits rhinovirus replication.
J Antimicrob Chemother
; 69(10): 2723-32, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24948704
16.
Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.
J Antimicrob Chemother
; 69(10): 2770-84, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24951535
17.
Base substituted 5'-O-(N-isoleucyl)sulfamoyl nucleoside analogues as potential antibacterial agents.
Bioorg Med Chem
; 22(10): 2875-86, 2014 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24746466
18.
Toward the computer-aided discovery of FabH inhibitors. Do predictive QSAR models ensure high quality virtual screening performance?
Mol Divers
; 18(3): 637-54, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24671521
19.
Solution structure and conformational dynamics of deoxyxylonucleic acids (dXNA): an orthogonal nucleic acid candidate.
Chemistry
; 18(3): 869-79, 2012 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22180030
20.
GA(M)E-QSAR: a novel, fully automatic genetic-algorithm-(meta)-ensembles approach for binary classification in ligand-based drug design.
J Chem Inf Model
; 52(9): 2366-86, 2012 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22856471