Detalhe da pesquisa
1.
Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1.
J Neurochem
; 168(1): 52-65, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38071490
2.
A novel C-terminal DxRSDxE motif in ceramide synthases involved in dimer formation.
J Biol Chem
; 298(2): 101517, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34942147
3.
Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis.
J Biol Chem
; 298(4): 101735, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35181339
4.
Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer.
J Biol Chem
; 298(2): 101492, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34915026
5.
Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death.
Mol Ther
; 30(4): 1661-1674, 2022 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34400330
6.
The fine-tuning of cell membrane lipid bilayers accentuates their compositional complexity.
Bioessays
; 43(5): e2100021, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33656770
7.
Ceramide synthase 2 deletion decreases the infectivity of HIV-1.
J Biol Chem
; 296: 100340, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33515546
8.
TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells.
PLoS Biol
; 17(3): e3000169, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30822302
9.
Substrate reduction therapy using Genz-667161 reduces levels of pathogenic components in a mouse model of neuronopathic forms of Gaucher disease.
J Neurochem
; 156(5): 692-701, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32743826
10.
Yeast ceramide synthases, Lag1 and Lac1, have distinct substrate specificity.
J Cell Sci
; 132(12)2019 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31164445
11.
Ceramide Synthase 2 Null Mice Are Protected from Ovalbumin-Induced Asthma with Higher T Cell Receptor Signal Strength in CD4+ T Cells.
Int J Mol Sci
; 22(5)2021 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33800208
12.
Different rates of flux through the biosynthetic pathway for long-chain versus very-long-chain sphingolipids.
J Lipid Res
; 61(10): 1341-1346, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32651186
13.
Fingolimod phosphate inhibits astrocyte inflammatory activity in mucolipidosis IV.
Hum Mol Genet
; 27(15): 2725-2738, 2018 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29771310
14.
Mice defective in interferon signaling help distinguish between primary and secondary pathological pathways in a mouse model of neuronal forms of Gaucher disease.
J Neuroinflammation
; 17(1): 265, 2020 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32892753
15.
Lysosomal Storage Disorders Shed Light on Lysosomal Dysfunction in Parkinson's Disease.
Int J Mol Sci
; 21(14)2020 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32674335
16.
Eleven residues determine the acyl chain specificity of ceramide synthases.
J Biol Chem
; 293(25): 9912-9921, 2018 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29632068
17.
Absence of infiltrating peripheral myeloid cells in the brains of mouse models of lysosomal storage disorders.
J Neurochem
; 148(5): 625-638, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29900534
18.
Ablation of the pro-inflammatory master regulator miR-155 does not mitigate neuroinflammation or neurodegeneration in a vertebrate model of Gaucher's disease.
Neurobiol Dis
; 127: 563-569, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30981829
19.
Oxidative stress elicited by modifying the ceramide acyl chain length reduces the rate of clathrin-mediated endocytosis.
J Cell Sci
; 130(8): 1486-1493, 2017 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28280117
20.
Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure.
FASEB J
; 32(4): 1880-1890, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29196503