Neural systems and the emotion-memory link.

The present brief review for this Special Issue summarizes some of the original research on the emotional modulation of memory. The review begins by highlighting the pioneering research from James L. McGaugh and colleagues demonstrating modulatory effects of post-training drug administration on memory consolidation, in particular the stress hormone epinephrine. The subsequent discovery of a critical role for the basolateral amygdala in emotional modulation of memory is described. Within the context of a multiple systems approach to memory focusing on selective roles for the hippocampus and dorsolateral striatum in cognitive and habit memory, the original studies indicating that robust emotional arousal can bias animals and humans toward the predominant use of habit memory are reviewed. This effect of emotional arousal on the relative use of multiple memory systems depends on a modulatory role of the basolateral amygdala. Finally, we briefly consider how an emotion-induced enhancement of dorsolateral striatal-dependent memory may be relevant to understanding maladaptive habitual behaviors in certain human psychopathologies.

Chronic corticosterone administration in adolescence enhances dorsolateral striatum-dependent learning in adulthood.

Previous evidence indicates a link between early life stress (ELS) in humans and a predisposition to psychopathologies that are characterized in part by maladaptive habitual behaviors. Stress and anxiety influence the relative use of mammalian memory systems implicated in these disorders. Specifically, cognitive memory functions of the hippocampus are typically impaired by stress/anxiety, whereas habit memory functions of the dorsolateral striatum (DLS) are enhanced. A stress/anxiety bias toward habit memory has largely been demonstrated in adult rodents and humans, and the effects of ELS on the later use of DLS-dependent habit memory in adult rodents have not been extensively examined. The present study addressed this question by chronically elevating corticosterone (CORT) during adolescence, and investigated the effects of this treatment on DLS-dependent habit learning in adulthood. In experiment 1, adolescent rats received a single daily injection of either CORT (5 mg/kg) or vehicle (cVEH) over 5 days and then matured undisturbed before training as adults in a DLS-dependent water plus-maze task. Rats administered CORT injections during adolescence displayed a strong trend toward enhanced learning during adulthood relative to vehicle-treated rats. Adolescent CORT administration also increased anxiety-like behavior in adulthood in an elevated plus-maze. In experiment 2, adolescent CORT administration enhanced task acquisition in adulthood, and this effect was blocked by concurrent administration of the glucocorticoid antagonist mifepristone (30 mg/kg). Taken together, these findings suggest that chronic elevation of glucocorticoids during adolescence are sufficient to facilitate habit learning in adulthood, and indicate that glucocorticoid function may be a potential underlying mechanism by which ELS influences subsequent habitual behaviors.