Detalhe da pesquisa
1.
Epigenetic instability may alter cell state transitions and anticancer drug resistance.
PLoS Comput Biol
; 17(8): e1009307, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34424912
2.
Inhibition of HIPK2 Alleviates Thoracic Aortic Disease in Mice With Progressively Severe Marfan Syndrome.
Arterioscler Thromb Vasc Biol
; 41(9): 2483-2493, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34320838
3.
Quantitative Systems Pharmacology: A Foundation To Establish Precision Medicine-Editorial.
J Pharmacol Exp Ther
; 387(1): 27-30, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37714689
4.
The effect of ABCG2 and ABCC4 on the pharmacokinetics of methotrexate in the brain.
Drug Metab Dispos
; 42(4): 537-40, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24464805
5.
Network Analyses of Brain Tumor Patients' Multiomic Data Reveals Pharmacological Opportunities to Alter Cell State Transitions.
bioRxiv
; 2024 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38766170
6.
Network Analyses of Brain Tumor Patients' Multiomic Data Reveals Pharmacological Opportunities to Alter Cell State Transitions.
Res Sq
; 2024 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38826227
7.
Cell state-directed therapy - epigenetic modulation of gene transcription demonstrated with a quantitative systems pharmacology model of temozolomide.
CPT Pharmacometrics Syst Pharmacol
; 12(3): 360-374, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36642831
8.
Activation of alternate prosurvival pathways accounts for acquired sunitinib resistance in U87MG glioma xenografts.
J Pharmacol Exp Ther
; 343(2): 509-19, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22869928
9.
Screening candidate anticancer drugs for brain tumor chemotherapy: pharmacokinetic-driven approach for a series of (E)-N-(substituted aryl)-3-(substituted phenyl)propenamide analogues.
Invest New Drugs
; 30(6): 2263-73, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22383114
10.
Preclinical pharmacokinetic and pharmacodynamic evaluation of novel anticancer agents, ON01910.Na (Rigosertib, Estybon™) and ON013105, for brain tumor chemotherapy.
Pharm Res
; 29(9): 2499-511, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22678771
11.
Educational Needs for Quantitative Systems Pharmacology Scientists.
Methods Mol Biol
; 2486: 335-343, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35437730
12.
Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models.
Drug Metab Dispos
; 39(11): 2155-61, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21841039
13.
Hybrid physiologically-based pharmacokinetic model for remdesivir: Application to SARS-CoV-2.
Clin Transl Sci
; 14(3): 1082-1091, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33404204
14.
Translocator protein (TSPO) ligand-Ara-C (cytarabine) conjugates as a strategy to deliver antineoplastic drugs and to enhance drug clinical potential.
Mol Pharm
; 7(6): 2255-69, 2010 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-20958082
15.
Predicting In Vivo Efficacy from In Vitro Data: Quantitative Systems Pharmacology Modeling for an Epigenetic Modifier Drug in Cancer.
Clin Transl Sci
; 13(2): 419-429, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31729169
16.
Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity.
Nat Commun
; 11(1): 4809, 2020 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32968055
17.
Differential effect of sunitinib on the distribution of temozolomide in an orthotopic glioma model.
Neuro Oncol
; 11(3): 301-10, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18971416
18.
Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide.
Clin Cancer Res
; 14(5): 1540-9, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18316579
19.
Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage.
Cancer Res
; 67(1): 262-8, 2007 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17210706
20.
Preclinical pharmacokinetic/pharmacodynamic models of gefitinib and the design of equivalent dosing regimens in EGFR wild-type and mutant tumor models.
Mol Cancer Ther
; 7(2): 407-17, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18281523