1.
Org Biomol Chem
; 12(11): 1793-803, 2014 Mar 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24514758
RESUMO
An efficient diastereoselective synthesis of brevipolide H derivative is described. The approach features the use of (i) catalytic asymmetric transfer hydrogenation, (ii) hydroxyl-directed cyclopropanation, and (iii) substrate-controlled catalytic epoxidation and ring-closing metathesis. Remarkably, in this convergent synthesis process, stereogenic centers were installed through catalytic reactions with high stereocontrol, which greatly facilitates the synthesis of stereo-divergent derivatives.