Pesquisa | BVS IEC

1.

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS.

Yu, Chien-Hsiung; Davidson, Sophia; Harapas, Cassandra R; Hilton, James B; Mlodzianoski, Michael J; Laohamonthonkul, Pawat; Louis, Cynthia; Low, Ronnie Ren Jie; Moecking, Jonas; De Nardo, Dominic; Balka, Katherine R; Calleja, Dale J; Moghaddas, Fiona; Ni, Erya; McLean, Catriona A; Samson, Andre L; Tyebji, Shiraz; Tonkin, Christopher J; Bye, Christopher R; Turner, Bradley J; Pepin, Genevieve; Gantier, Michael P; Rogers, Kelly L; McArthur, Kate; Crouch, Peter J; Masters, Seth L.

Cell ; 183(3): 636-649.e18, 2020 10 29.

Artigo em Inglês | MEDLINE | ID: mdl-33031745

2.

TLR7 gain-of-function genetic variation causes human lupus.

Brown, Grant J; Cañete, Pablo F; Wang, Hao; Medhavy, Arti; Bones, Josiah; Roco, Jonathan A; He, Yuke; Qin, Yuting; Cappello, Jean; Ellyard, Julia I; Bassett, Katharine; Shen, Qian; Burgio, Gaetan; Zhang, Yaoyuan; Turnbull, Cynthia; Meng, Xiangpeng; Wu, Phil; Cho, Eun; Miosge, Lisa A; Andrews, T Daniel; Field, Matt A; Tvorogov, Denis; Lopez, Angel F; Babon, Jeffrey J; López, Cristina Aparicio; Gónzalez-Murillo, África; Garulo, Daniel Clemente; Pascual, Virginia; Levy, Tess; Mallack, Eric J; Calame, Daniel G; Lotze, Timothy; Lupski, James R; Ding, Huihua; Ullah, Tomalika R; Walters, Giles D; Koina, Mark E; Cook, Matthew C; Shen, Nan; de Lucas Collantes, Carmen; Corry, Ben; Gantier, Michael P; Athanasopoulos, Vicki; Vinuesa, Carola G.

Nature ; 605(7909): 349-356, 2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-35477763

3.

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.

Nold-Petry, Claudia A; Lo, Camden Y; Rudloff, Ina; Elgass, Kirstin D; Li, Suzhao; Gantier, Michael P; Lotz-Havla, Amelie S; Gersting, Søren W; Cho, Steven X; Lao, Jason C; Ellisdon, Andrew M; Rotter, Björn; Azam, Tania; Mangan, Niamh E; Rossello, Fernando J; Whisstock, James C; Bufler, Philip; Garlanda, Cecilia; Mantovani, Alberto; Dinarello, Charles A; Nold, Marcel F.

Nat Immunol ; 16(4): 354-65, 2015 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-25729923

4.

Mammalian cells internalize bacteriophages and use them as a resource to enhance cellular growth and survival.

Bichet, Marion C; Adderley, Jack; Avellaneda-Franco, Laura; Magnin-Bougma, Isabelle; Torriero-Smith, Natasha; Gearing, Linden J; Deffrasnes, Celine; David, Cassandra; Pepin, Genevieve; Gantier, Michael P; Lin, Ruby Cy; Patwa, Ruzeen; Moseley, Gregory W; Doerig, Christian; Barr, Jeremy J.

PLoS Biol ; 21(10): e3002341, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-37883333

5.

Powering on cGAMP mini factories.

Gantier, Michael P.

EMBO Rep ; 23(1): e54231, 2022 01 05.

Artigo em Inglês | MEDLINE | ID: mdl-34796613

6.

Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2'-O-methyl gapmer oligonucleotides.

Valentin, Roxane; Wong, Christophe; Alharbi, Arwaf S; Pradeloux, Solène; Morros, Makala P; Lennox, Kim A; Ellyard, Julia I; Garcin, Aurélie J; Ullah, Tomalika R; Kusuma, Gina D; Pépin, Geneviève; Li, Hong-Mei; Pearson, Jaclyn S; Ferrand, Jonathan; Lim, Rebecca; Veedu, Rakesh N; Morand, Eric F; Vinuesa, Carola G; Behlke, Mark A; Gantier, Michael P.

Nucleic Acids Res ; 49(11): 6082-6099, 2021 06 21.

Artigo em Inglês | MEDLINE | ID: mdl-34057477

7.

Rational design of antisense oligonucleotides modulating the activity of TLR7/8 agonists.

Alharbi, Arwaf S; Garcin, Aurélie J; Lennox, Kim A; Pradeloux, Solène; Wong, Christophe; Straub, Sarah; Valentin, Roxane; Pépin, Geneviève; Li, Hong-Mei; Nold, Marcel F; Nold-Petry, Claudia A; Behlke, Mark A; Gantier, Michael P.

Nucleic Acids Res ; 48(13): 7052-7065, 2020 07 27.

Artigo em Inglês | MEDLINE | ID: mdl-32544249

8.

miRNA length variation during macrophage stimulation confounds the interpretation of results: implications for miRNA quantification by RT-qPCR.

Pillman, Katherine A; Goodall, Gregory J; Bracken, Cameron P; Gantier, Michael P.

RNA ; 25(2): 232-238, 2019 02.

Artigo em Inglês | MEDLINE | ID: mdl-30487268

9.

Necrotic cell death increases the release of macrophage migration inhibitory factor by monocytes/macrophages.

Dankers, Wendy; Hasnat, Md Abul; Swann, Vanesa; Alharbi, Arwaf; Lee, Jacinta Pw; Cristofaro, Megan A; Gantier, Michael P; Jones, Sarah A; Morand, Eric F; Flynn, Jacqueline K; Harris, James.

Immunol Cell Biol ; 98(9): 782-790, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32654231

10.

miR-222 isoforms are differentially regulated by type-I interferon.

Nejad, Charlotte; Pillman, Katherine A; Siddle, Katherine J; Pépin, Geneviève; Änkö, Minna-Liisa; McCoy, Claire E; Beilharz, Traude H; Quintana-Murci, Lluís; Goodall, Gregory J; Bracken, Cameron P; Gantier, Michael P.

RNA ; 24(3): 332-341, 2018 03.

Artigo em Inglês | MEDLINE | ID: mdl-29263133

11.

Activation of cGAS-dependent antiviral responses by DNA intercalating agents.

Pépin, Geneviève; Nejad, Charlotte; Thomas, Belinda J; Ferrand, Jonathan; McArthur, Kate; Bardin, Philip G; Williams, Bryan R G; Gantier, Michael P.

Nucleic Acids Res ; 45(1): 198-205, 2017 Jan 09.

Artigo em Inglês | MEDLINE | ID: mdl-27694309

12.

Naturally existing isoforms of miR-222 have distinct functions.

Yu, Feng; Pillman, Katherine A; Neilsen, Corine T; Toubia, John; Lawrence, David M; Tsykin, Anna; Gantier, Michael P; Callen, David F; Goodall, Gregory J; Bracken, Cameron P.

Nucleic Acids Res ; 45(19): 11371-11385, 2017 Nov 02.

Artigo em Inglês | MEDLINE | ID: mdl-28981911

13.

Cre-dependent DNA recombination activates a STING-dependent innate immune response.

Pépin, Geneviève; Ferrand, Jonathan; Höning, Klara; Jayasekara, W Samantha N; Cain, Jason E; Behlke, Mark A; Gough, Daniel J; G Williams, Bryan R; Hornung, Veit; Gantier, Michael P.

Nucleic Acids Res ; 44(11): 5356-64, 2016 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-27166376

14.

BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs.

Sadler, Anthony J; Rossello, Fernando J; Yu, Liang; Deane, James A; Yuan, Xiangliang; Wang, Die; Irving, Aaron T; Kaparakis-Liaskos, Maria; Gantier, Michael P; Ying, Hangjie; Yim, Howard C H; Hartland, Elizabeth L; Notini, Amanda J; de Boer, Suzan; White, Stefan J; Mansell, Ashley; Liu, Jun-Ping; Watkins, D Neil; Gerondakis, Steve; Williams, Bryan R G; Xu, Dakang.

Proc Natl Acad Sci U S A ; 112(5): 1535-40, 2015 Feb 03.

Artigo em Inglês | MEDLINE | ID: mdl-25605927

15.

Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors.

Sarvestani, Soroush T; Stunden, H James; Behlke, Mark A; Forster, Samuel C; McCoy, Claire E; Tate, Michelle D; Ferrand, Jonathan; Lennox, Kim A; Latz, Eicke; Williams, Bryan R G; Gantier, Michael P.

Nucleic Acids Res ; 43(2): 1177-88, 2015 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-25539920

16.

cGAS-STING Activation in the Tumor Microenvironment and Its Role in Cancer Immunity.

Pépin, Geneviève; Gantier, Michael P.

Adv Exp Med Biol ; 1024: 175-194, 2017.

Artigo em Inglês | MEDLINE | ID: mdl-28921470

17.

Reply.

Gantier, Michael P.

Respirology ; 26(6): 618, 2021 06.

Artigo em Inglês | MEDLINE | ID: mdl-33851503

18.

Animal models of COVID-19 hyper-inflammation.

Gantier, Michael P.

Respirology ; 26(3): 222-224, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33350019

19.

Integrin-linked kinase modulates lipopolysaccharide- and Helicobacter pylori-induced nuclear factor κB-activated tumor necrosis factor-α production via regulation of p65 serine 536 phosphorylation.

Ahmed, Afsar U; Sarvestani, Soroush T; Gantier, Michael P; Williams, Bryan R G; Hannigan, Gregory E.

J Biol Chem ; 289(40): 27776-93, 2014 Oct 03.

Artigo em Inglês | MEDLINE | ID: mdl-25100717

20.

The role of Ets2 transcription factor in the induction of microRNA-155 (miR-155) by lipopolysaccharide and its targeting by interleukin-10.

Quinn, Susan R; Mangan, Niamh E; Caffrey, Brian E; Gantier, Michael P; Williams, Bryan R G; Hertzog, Paul J; McCoy, Claire E; O'Neill, Luke A J.

J Biol Chem ; 289(7): 4316-25, 2014 Feb 14.

Artigo em Inglês | MEDLINE | ID: mdl-24362029

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TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS.

TLR7 gain-of-function genetic variation causes human lupus.

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.

Mammalian cells internalize bacteriophages and use them as a resource to enhance cellular growth and survival.

Powering on cGAMP mini factories.

Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2'-O-methyl gapmer oligonucleotides.

Rational design of antisense oligonucleotides modulating the activity of TLR7/8 agonists.

miRNA length variation during macrophage stimulation confounds the interpretation of results: implications for miRNA quantification by RT-qPCR.

Necrotic cell death increases the release of macrophage migration inhibitory factor by monocytes/macrophages.

miR-222 isoforms are differentially regulated by type-I interferon.

Activation of cGAS-dependent antiviral responses by DNA intercalating agents.

Naturally existing isoforms of miR-222 have distinct functions.

Cre-dependent DNA recombination activates a STING-dependent innate immune response.

BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs.

Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors.

cGAS-STING Activation in the Tumor Microenvironment and Its Role in Cancer Immunity.

Reply.

Animal models of COVID-19 hyper-inflammation.

Integrin-linked kinase modulates lipopolysaccharide- and Helicobacter pylori-induced nuclear factor κB-activated tumor necrosis factor-α production via regulation of p65 serine 536 phosphorylation.

The role of Ets2 transcription factor in the induction of microRNA-155 (miR-155) by lipopolysaccharide and its targeting by interleukin-10.