Detalhe da pesquisa
1.
Structural basis for backbone N-methylation by an interrupted adenylation domain.
Nat Chem Biol
; 14(5): 428-430, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29556104
2.
Deciphering Nature's Intricate Way of N,S-Dimethylating l-Cysteine: Sequential Action of Two Bifunctional Adenylation Domains.
Biochemistry
; 56(46): 6087-6097, 2017 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-29112395
3.
Activation and Loading of the Starter Unit during Thiocoraline Biosynthesis.
Biochemistry
; 56(34): 4457-4467, 2017 08 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-28762729
4.
Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors.
Bioorg Med Chem Lett
; 26(15): 3581-5, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27381083
5.
Enzymatic Evidence for a Revised Congocidine Biosynthetic Pathway.
Chembiochem
; 16(9): 1307-13, 2015 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25958990
6.
Solvent-dependent enantiodivergence in the chlorocyclization of unsaturated carbamates.
Chemistry
; 19(27): 9015-21, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23671005
7.
Discovery and Optimization of 6-(1-Substituted pyrrole-2-yl)-s-triazine Containing Compounds as Antibacterial Agents.
ACS Infect Dis
; 8(4): 757-767, 2022 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35239306
8.
Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity.
Eur J Med Chem
; 242: 114698, 2022 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36037791
9.
Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design.
PLoS One
; 16(1): e0245013, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33482665
10.
Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance.
RSC Med Chem
; 12(11): 1894-1909, 2021 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34825186
11.
A minimalist NMR approach for the structural revision of mucoxin.
Chemistry
; 16(46): 13749-56, 2010 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21089037
12.
Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis.
ACS Infect Dis
; 4(6): 1030-1040, 2018 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29601176
13.
Interfering With DNA Decondensation as a Strategy Against Mycobacteria.
Front Microbiol
; 9: 2034, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30233521
14.
Novel alkylated azoles as potent antifungals.
Eur J Med Chem
; 133: 309-318, 2017 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28395217
15.
Repurposing antipsychotic drugs into antifungal agents: Synergistic combinations of azoles and bromperidol derivatives in the treatment of various fungal infections.
Eur J Med Chem
; 139: 12-21, 2017 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28797882
16.
Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors.
ACS Infect Dis
; 3(4): 302-309, 2017 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28192916
17.
A catalytic asymmetric chlorocyclization of unsaturated amides.
Angew Chem Int Ed Engl
; 50(11): 2593-6, 2011 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21370344
18.
Discovery and Optimization of Two Eis Inhibitor Families as Kanamycin Adjuvants against Drug-Resistant M. tuberculosis.
ACS Med Chem Lett
; 7(12): 1219-1221, 2016 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27994767
19.
Discovery of Allosteric and Selective Inhibitors of Inorganic Pyrophosphatase from Mycobacterium tuberculosis.
ACS Chem Biol
; 11(11): 3084-3092, 2016 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27622287
20.
Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis.
J Med Chem
; 59(23): 10619-10628, 2016 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27933949