Detalhe da pesquisa
1.
Small-molecule IKKß activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth.
Proc Natl Acad Sci U S A
; 119(18): e2115071119, 2022 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35476515
2.
Intramuscular and subcutaneous administration of antiretroviral drugs, compared with oral, enhances delivery to lymphoid tissues in BALB/c mice.
J Antimicrob Chemother
; 76(10): 2651-2658, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34312680
3.
A year-long extended release nanoformulated cabotegravir prodrug.
Nat Mater
; 19(8): 910-920, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32341511
4.
Synthesis and Characterization of Long-Acting Darunavir Prodrugs.
Mol Pharm
; 17(1): 155-166, 2020 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31742407
5.
Head-to-head comparative pharmacokinetic and biodistribution (PK/BD) study of two dexamethasone prodrug nanomedicines on lupus-prone NZB/WF1 mice.
Nanomedicine
; 29: 102266, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32679269
6.
Assessing the lymphoid tissue bioavailability of antiretrovirals in human primary lymphoid endothelial cells and in mice.
J Antimicrob Chemother
; 74(10): 2974-2978, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31335938
7.
Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators.
Bioorg Med Chem Lett
; 29(6): 791-796, 2019 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30718161
8.
Pharmacokinetics of a Long-Acting Nanoformulated Dolutegravir Prodrug in Rhesus Macaques.
Antimicrob Agents Chemother
; 62(1)2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29061742
9.
Species differences in bile acids II. Bile acid metabolism.
J Appl Toxicol
; 38(10): 1336-1352, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29845631
10.
Species differences in bile acids I. Plasma and urine bile acid composition.
J Appl Toxicol
; 38(10): 1323-1335, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29785833
11.
Simultaneous LC-MS/MS analysis of eicosanoids and related metabolites in human serum, sputum and BALF.
Biomed Chromatogr
; 32(3)2018 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-28975688
12.
Pharmacokinetic studies of a novel trioxane antimalarial (99/411) in rats and monkeys using LC-MS/MS.
Biomed Chromatogr
; 30(12): 2038-2043, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27352248
13.
Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal.
J Antimicrob Chemother
; 70(6): 1788-97, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25691324
14.
Impaired synaptic development in a maternal immune activation mouse model of neurodevelopmental disorders.
Brain Behav Immun
; 50: 249-258, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26218293
15.
Peripherally cross-linking the shell of core-shell polymer micelles decreases premature release of physically loaded combretastatin A4 in whole blood and increases its mean residence time and subsequent potency against primary murine breast tumors after IV administration.
Pharm Res
; 32(3): 1028-44, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25223962
16.
Irreversible binding of an anticancer compound (BI-94) to plasma proteins.
Xenobiotica
; 45(10): 858-73, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25869245
17.
Pharmacokinetics, biodistribution, and toxicity of folic acid-coated antiretroviral nanoformulations.
Antimicrob Agents Chemother
; 58(12): 7510-9, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25288084
18.
Preclinical pharmacokinetics and tissue distribution of long-acting nanoformulated antiretroviral therapy.
Antimicrob Agents Chemother
; 57(7): 3110-20, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23612193
19.
Pharmacokinetics, protein binding and metabolism of a quinoxaline urea analog as an NF-κB inhibitor in mice and rats by LC-MS/MS.
Biomed Chromatogr
; 27(7): 900-9, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23483555
20.
Analyte recovery in LC-MS/MS bioanalysis: An old issue revisited.
Anal Chim Acta
; 1198: 339512, 2022 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35190119