Detalhe da pesquisa
1.
Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products.
Nat Prod Rep
; 41(6): 885-904, 2024 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38351834
2.
High Plasticity of the Amicetin Biosynthetic Pathway in Streptomyces sp. SHP 22-7 Led to the Discovery of Streptcytosine P and Cytosaminomycins F and G and Facilitated the Production of 12F-Plicacetin.
J Nat Prod
; 85(3): 530-539, 2022 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35263115
3.
Towards enantioselective ultrahigh performance liquid chromatography-mass spectrometry-based metabolomics of branched-chain fatty acids and anteiso-fatty acids under reversed-phase conditions using sub-2-µm amylose- and cellulose-derived chiral stationary phases.
Chirality
; 34(3): 484-497, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35032056
4.
Development and chromatographic exploration of stable-bonded cross-linked amino silica against classical amino phases.
J Sep Sci
; 45(17): 3286-3300, 2022 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-35652610
5.
Discovery and Evaluation of Enantiopure 9H-pyrimido[4,5-b]indoles as Nanomolar GSK-3ß Inhibitors with Improved Metabolic Stability.
Int J Mol Sci
; 21(21)2020 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33105671
6.
ModiFinder: Tandem Mass Spectral Alignment Enables Structural Modification Site Localization.
J Am Soc Mass Spectrom
; 2024 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38830143
7.
Branched medium-chain fatty acid profiling and enantiomer separation of anteiso-forms of teicoplanin fatty acyl side chain RS3 using UHPLC-MS/MS with polysaccharide columns.
J Pharm Biomed Anal
; 224: 115162, 2023 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36423498
8.
Design and Optimization of Novel Benzimidazole- and Imidazo[4,5-b]pyridine-Based ATM Kinase Inhibitors with Subnanomolar Activities.
J Med Chem
; 66(11): 7304-7330, 2023 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37226670
9.
Study of microheterogeneity of silatrane-based silica surface bonding chemistry and its optimization for the synthesis of chiral stationary phases for enantioselective liquid chromatography.
J Chromatogr A
; 1674: 463138, 2022 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35617910
10.
Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity.
Eur J Med Chem
; 235: 114234, 2022 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35325634
11.
Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3ß Inhibitors.
J Med Chem
; 65(2): 1283-1301, 2022 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34213342
12.
Enantioselective multiple heart cutting online two-dimensional liquid chromatography-mass spectrometry of all proteinogenic amino acids with second dimension chiral separations in one-minute time scales on a chiral tandem column.
Anal Chim Acta
; 1180: 338858, 2021 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34538327
13.
Preparation and characterization of poly(3-mercaptopropyl)methylsiloxane functionalized silica particles and their further modification for silver ion chromatography and enantioselective high-performance liquid chromatography.
J Chromatogr A
; 1643: 462069, 2021 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33784503
14.
Controllable organosilane monolayer density of surface bonding using silatranes for thiol functionalization of silica particles for liquid chromatography and validation of microanalytical method for elemental composition determination.
J Chromatogr A
; 1653: 462418, 2021 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34340056
15.
DoE Optimization Empowers the Automated Preparation of Enantiomerically Pure [18F]Talazoparib and its In Vivo Evaluation as a PARP Radiotracer.
J Med Chem
; 64(21): 15690-15701, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34672571
16.
Thiol-ene photo-click immobilization of a chiral chromatographic ligand on silica particles.
J Chromatogr A
; 1622: 461133, 2020 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32354557
17.
Evaluation of superficially porous particle based zwitterionic chiral ion exchangers against fully porous particle benchmarks for enantioselective ultra-high performance liquid chromatography.
J Chromatogr A
; 1603: 130-140, 2019 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31235330