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1.
Strahlenther Onkol ; 198(7): 648-653, 2022 07.
Artigo em Inglês | MEDLINE | ID: mdl-35278096

RESUMO

PURPOSE: This study aimed to evaluate the therapeutic effect of radiotherapy and to determine possible prognostic factors in patients with painful vertebral hemangioma. METHODS: In the last two decades, 80 patients with vertebral hemangioma who received radiotherapy in our institute were evaluated in terms of pain response, treatment-related side effects, and prognostic factors. All patients were questioned 3 months after radiotherapy for the evaluation of pain response and were divided into three groups (complete response, partial response, and no change). Moreover, the visual analog scale (VAS) was used for pain response assessment in 46 patients. Pain status was assessed to detect recurrence at each clinical examination during the follow-up period. Possible prognostic factors such as gender, size of the hemangioma, location, multilevel involvement and additional musculoskeletal disease on pain response were analyzed. RESULTS: In this study, 45 individuals had lesions in the lumbar spine, 28 in the thoracic, and 7 in the cervical region. Furthermore, 51 patients had additional musculoskeletal conditions such as disc herniation, degenerative diseases, spondylolisthesis, and compression fracture. Radiotherapy was performed with a median daily dose of 2 Gy and a median total dose of 40 Gy. Complete pain response occurred in 58.8% of patients, 26.2% of patients had partial pain response, and 15% of patients had no pain response. The overall response rate was 85%, and 7 patients showed recurrent pain symptoms in the overall response group at routine follow-up. Additional musculoskeletal disorders were found to be the only prognostic factor associated with pain response. The median follow-up time was 60 months. Secondary malignancy was not found in any of the patients in this short follow-up time. No acute or late radiation-associated side effects greater than grade II were observed. CONCLUSION: To our best knowledge, this study is one of the largest single-institution radiotherapy series on vertebral hemangiomas reported to date. The obtained data support the efficacy and safety of radiotherapy in the treatment of painful vertebral hemangioma. Our study showed that additional musculoskeletal disease plays an important role in pain response. Other prognostic factors and treatment of vertebral hemangioma with stereotactic radiosurgery should be investigated in future studies.


Assuntos
Hemangioma , Neoplasias da Coluna Vertebral , Hemangioma/complicações , Hemangioma/radioterapia , Hemangioma/cirurgia , Humanos , Dor , Medição da Dor , Estudos Retrospectivos , Neoplasias da Coluna Vertebral/radioterapia , Neoplasias da Coluna Vertebral/cirurgia , Resultado do Tratamento
2.
Gynecol Endocrinol ; 32(8): 634-640, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-26939766

RESUMO

OBJECTIVE: The aim of this study is to investigate the effects of resveratrol in a rat model of ovarian hyperstimulation syndrome (OHSS) and compare with cabergoline. DESIGN: Randomized controlled, animal study. ANIMAL(S): Female Wistar rats. MATERIAL AND METHODS: A rat OHSS model was used to investigate the effects of resveratrol compare with cabergoline administration for preventing OHSS. Body weight, ovary weight, diameter, vascular permeability (VP), vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2) expression (immunohistochemistry), and serum estradiol (E2) levels were then compared. RESULTS: The ovarian VEGF concentration was significantly increased in the OHSS Groups (Groups 3-5) compared with the control groups (1 and 2). But vascular permeability, VEGF, and COX-2 expressions were reduced in animals treated with the resveratrol group compared with the cabergoline group (group 5) and the severe OHSS (group 3) group. Blood E2 levels were decreased in group treated with the resveratrol group compared with the cabergoline group (group 5) and severe the OHSS (group 3) group. CONCLUSION(S): Our results in a rat model suggest that resveratrol has a beneficial effect on OHSS by reducing the increases in ovarian daimeter, VP, and VEGF expression associated with OHSS. These effects may be mediated by the COX-2 inhibitory capacity of resveratrol.


Assuntos
Antioxidantes/farmacologia , Agonistas de Dopamina/farmacologia , Ergolinas/farmacologia , Síndrome de Hiperestimulação Ovariana/prevenção & controle , Ovário/efeitos dos fármacos , Estilbenos/farmacologia , Animais , Antioxidantes/administração & dosagem , Cabergolina , Modelos Animais de Doenças , Agonistas de Dopamina/administração & dosagem , Ergolinas/administração & dosagem , Feminino , Distribuição Aleatória , Ratos , Ratos Wistar , Resveratrol , Estilbenos/administração & dosagem
3.
Arch Gynecol Obstet ; 293(5): 1101-6, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-26690356

RESUMO

OBJECTIVE: To evaluate the effects of letrozole and cabergoline in a rat model of ovarian hyperstimulation syndrome (OHSS). STUDY DESIGN: In this prospective, controlled experimental study, the 28 female Wistar rats were divided into four subgroups (one non-stimulated control and three OHSS-positive groups: placebo, letrozole, and cabergoline). To induce OHSS, rats were injected with 10 IU of pregnant mare serum gonadotropin from day 29 to day 32 of life, followed by subcutaneous injection of 30 IU hCG on day 33. Letrozole rats received with a single dose of 0.1 mg/kg letrozole via oral gavage, on the hCG day. Cabergoline rats received with a single dose of 100 µg/kg cabergoline via oral gavage, on the hCG day. All animals were compared in terms of body weight, vascular permeability (VP), ovarian diameter, ovarian tissue VEGF expression (assessed via immunohistochemical staining), and blood pigment epithelium-derived growth factor (PEDF) levels. RESULTS: The OHSS-positive placebo group (group 2) exhibited the highest VP, ovarian diameter, extent of VEGF staining, and lowest PEDF level, as expected. No significant difference was evident between the letrozole and cabergoline groups in terms of any of body weight; VP; PEDF level; ovarian diameter; or the staining intensity of, or percentage staining for, VEGF in ovarian tissues. CONCLUSIONS: Letrozole and cabergoline were equally effective to prevent OHSS, reducing the ovarian diameter, VP, and PEDF and VEGF levels to similar extents.


Assuntos
Permeabilidade Capilar/efeitos dos fármacos , Ergolinas/administração & dosagem , Proteínas do Olho/sangue , Fatores de Crescimento Neural/sangue , Nitrilas/administração & dosagem , Síndrome de Hiperestimulação Ovariana/prevenção & controle , Ovário/metabolismo , Serpinas/sangue , Triazóis/administração & dosagem , Fator A de Crescimento do Endotélio Vascular/sangue , Animais , Cabergolina , Gonadotropina Coriônica/farmacologia , Ergolinas/farmacologia , Feminino , Gonadotropinas Equinas/farmacologia , Humanos , Letrozol , Nitrilas/farmacologia , Gravidez , Estudos Prospectivos , Ratos , Ratos Wistar , Triazóis/farmacologia
4.
Ginekol Pol ; 87(5): 378-83, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27304655

RESUMO

OBJECTIVES: The aim of our study was to evaluate the association of vitamin D deficiency (VDD) during pregnancy with thymus size in full-term fetuses. MATERIAL AND METHODS: In this prospective study, we evaluated mid-pregnancy serum 25-hydroxyvitamin D3 (25(OH)D3) concentrations. The fetal thymus size was measured by ultrasound in the third trimester. Neonatal 25(OH)D3 levels were evaluated by umbilical cord blood sampling. Correlation of maternal and neonatal vitamin D levels and association between thymus size and both, maternal and neonatal vitamin D concentrations were investigated. RESULTS: Serum 25(OH) D3 concentrations were within the normal range in 48 (29.8%) mothers and 10 (13.1%) new-borns. A strong correlation between mid-pregnancy maternal and neonatal 25(OH)D3 concentration (r = 0.8, p < 0.001) was found. A significant linear correlation was observed between both, maternal and neonatal 25(OH)D3 concentrations and thymus perimeter length (r = 0.45, p = 0.04 and r = 0.43, p < 0.01, respectively). Both, maternal and fetal VDDs were associated with decreased thymus perimeter (p = 0.04, p = 0.03). CONCLUSIONS: Vitamin D deficiency during pregnancy may be associated with smaller fetal thymus. Our data suggest that VDD in pregnancy may lead to systemic inflammatory response in the fetus.


Assuntos
Complicações na Gravidez/sangue , Timo , Deficiência de Vitamina D , Vitamina D , Adulto , Suplementos Nutricionais , Feminino , Sangue Fetal , Desenvolvimento Fetal/fisiologia , Humanos , Recém-Nascido , Tamanho do Órgão , Gravidez , Estatística como Assunto , Timo/crescimento & desenvolvimento , Timo/patologia , Vitamina D/sangue , Vitamina D/farmacologia , Deficiência de Vitamina D/sangue , Deficiência de Vitamina D/complicações , Vitaminas/farmacologia
5.
Gynecol Obstet Invest ; 80(2): 119-23, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25662613

RESUMO

OBJECTIVE: The aim of this study was to evaluate the expression of cyclooxygenase 2 (COX-2) and its association with the development of premalignant lesions in gland structures of the endometrium in patients with uterine prolapse, a condition which exposes the uterus to mechanical and infectious stress. METHODS: The study included 102 patients who underwent hysterectomy to correct grade 3-4 uterine prolapse and 105 patients who underwent hysterectomy for other causes. Endometrial gland structures underwent immunohistochemical staining and COX-2 expression was graded. Grades 0 and 1 represent low expression; grades 2 and 3 correspond to high levels of COX-2 expression. RESULTS: The prevalence of grade 2-3 COX-2 expression was significantly higher in the endometrial gland structures of patients with prolapse and hyperplasia compared to the remaining patients (p = 0.014). Grade 0-1 COX-2 expression was significantly more common in the endometrial gland structures of patients without uterine prolapse or hyperplasia (p = 0.004). Among the patients without endometrial hyperplasia, COX-2 expression was elevated in the endometrial gland structures of those with uterine prolapse compared to those without prolapse. CONCLUSION: Elevated COX-2 expression may explain the presence of unexpected premalignant lesions of the endometrium in patients with uterine prolapse.


Assuntos
Ciclo-Oxigenase 2/metabolismo , Hiperplasia Endometrial/patologia , Neoplasias do Endométrio/patologia , Endométrio/metabolismo , Endométrio/patologia , Inflamação/metabolismo , Prolapso Uterino/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias do Endométrio/etiologia , Feminino , Humanos , Histerectomia , Inflamação/complicações , Pessoa de Meia-Idade
6.
Arch Gynecol Obstet ; 291(4): 877-81, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25280573

RESUMO

OBJECTIVE: The aim of the present study is to determine the potential risk factors for adenomyosis and to investigate its relationship with accompanying gynecological pathologies and clinical characteristics. MATERIALS AND METHOD: This study is a retrospective analysis of 945 patients who underwent hysterectomy between May 2005 and January 2013 at the Sifa University Medical Faculty Hospital, Clinic of Obstetrics and Gynecology. The study included 327 patients with adenomyosis and 618 patients without adenomyosis by histopathological examination of the uterus. RESULTS: There was a significant positive correlation between development of adenomyosis and presence of leiomyoma (p < 0.0001), history of previous abortion (p < 0.0001), history of previous pregnancy (p = 0.0002), and normal body mass index (p < 0.0001). However, no significant relationship existed between development of adenomyosis and smoking (p > 0.4300), normal delivery (p = 0.9600), cesarean delivery (p = 0.5705), endometrial hyperplasia (p = 0.1721), or ovarian endometriosis (p = 0.8595). CONCLUSION: Women who are multiparous have leiomyoma, a previous history of abortion, and a normal body mass index are at increased risk for development of adenomyosis. Adenomyosis might be one cause of unexplained recurrent spontaneous abortion during pregnancy.


Assuntos
Adenomiose/complicações , Hiperplasia Endometrial/etiologia , Endometriose/etiologia , Histerectomia , Aborto Espontâneo/etiologia , Aborto Espontâneo/patologia , Adenomiose/patologia , Adulto , Estudos de Casos e Controles , Cesárea , Hiperplasia Endometrial/patologia , Endometriose/patologia , Feminino , Humanos , Leiomioma/cirurgia , Paridade , Gravidez , Estudos Retrospectivos , Risco , Fatores de Risco
7.
Ginekol Pol ; 86(9): 666-71, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26665567

RESUMO

OBJECTIVES: The aim of the study was to investigate the relationship between thyroid antibodies and hematological parameters in euthyroid or subclinical hypothyroidic (S H) pregnant women with autoimmune hypothyroidism and to verity whether these pregnant women are affected by a higher rate of postpartum hemorrhage. MATERIAL AND METHODS: Thirty-six out hyroid and 21 S H pregnant women with autoimmune thyroid disease and 52 healthy pregnant women were evaluated. The relationship between thyroid hormones, thyroid antibodies level, the dosage of Levotroxin (LT4) and hematological parameters and the amount of postpartum bleeding was investigated. RESULTS: The mean platelet volume (MPV), was significantly higher in the SH group than in the euthyroid group and in the euthyroid group than healthy group (p<0.001). Hemoglobin (Hb) was significantly lower in both the SH group and the euthyroid group than control group (p<0.001). Other hematological parameters and the amount of postpartum bleeding did not differ between the groups. The correlation between Hb and fT3, FT4 was significant and positive, whereas between Hb and T SH was significant and negative (r=0.3 p<0.01, r=0.2 p=0.01, and r = -0.18 p=0.04, respectively). There was a significant and negative correlation between the PLT count and FT4, PT and FT3 (r = -0.2 p=0.01, r = -0.3 p<0.01, and r = -0.3 p<0.01, respectively). CONCLUSION: It has been described that being thyroid antibody-positive (TAb+) may be a risk factor for anemia and high MPV. However euthyroid and SH pregnant women with thyroid antibodies do not differ in terms of other coagulation parameters and postpartum hemorrhage from healthy controls.


Assuntos
Autoanticorpos/sangue , Doença de Hashimoto/sangue , Imunoglobulinas Estimuladoras da Glândula Tireoide/sangue , Hemorragia Pós-Parto/sangue , Tireoidite Autoimune/sangue , Biomarcadores/sangue , Estudos de Casos e Controles , Feminino , Doença de Hashimoto/prevenção & controle , Humanos , Ativação Plaquetária , Hemorragia Pós-Parto/prevenção & controle , Pré-Eclâmpsia/sangue , Gravidez , Índice de Gravidade de Doença , Testes de Função Tireóidea , Tireoidite Autoimune/prevenção & controle
8.
Arch Ital Urol Androl ; 86(3): 233-4, 2014 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-25308596

RESUMO

Although endometriosis is a common disease in women of reproductive age, urinary system endometriosis is an exceedingly rare disease that may cause important clinical problems. In this paper we discussed a 42-year-old woman who had urinary bladder endometriosis misdiagnosed as urinary bladder tumor in imaging modalities. The diagnosis of endometriosis was made by histopathological examination of the operative material after partial resection of the urinary bladder. Urinary bladder endometriosis causes nonspecific signs and symptoms in many patients. In female patients presenting with unexplained urinary symptoms the differential diagnosis should include urinary bladder endometriosis that may mimic urinary bladder cancer and lead to difficulties in making definitive preoperative diagnosis.

9.
Ginekol Pol ; 85(11): 823-7, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25675798

RESUMO

OBJECTIVE: Ectopic pregnancy (EP) is the major cause of maternal morbidity and is responsible for maternal mortality in the first trimester. In order to reduce undesirable results, it is necessary to find rapid and accurate, non-surgical diagnostic tests for ER The goal of the study was to investigate the differences in complete blood count parameters between tubal EPs and healthy pregnancies in be used in the diagnosis of ectopic pregnancy. STUDY DESIGN: White blood cell (WBC), neutrophil, monocyte, lymphocyte, platelet (PLT) counts, mean PLT volume (MPV) and PLT distribution width (PDW) levels in the complete blood count samples have been obtained from subjects with diagnosed tubal EP (n=78; study group) and women with healthy intrauterine gestations (n=79; control group). Statistical comparisons between groups were performed using the t test. RESULTS: PDW levels were found to be significantly higher in the control group than EP (p<0.001). However no differences between the study and control groups with regard to PLT and MPV levels were observed. WBC levels were found to be significantly higher in the EP group as compared to controls (p<0.001). When leukocyte differentials were compared, monocyte counts in the EP group were significantly higher than in controls (p=0.005). No statistically significant differences in neutrophil and lymphocyte values were observed in either group. CONCLUSION: PDW as an indicator of PLT activation is lower in tubal EP than intrauterine pregnancy so, possibly endometrial invasion in the intrauterine pregnancy needs more PLT activation. Monocyte counts are higher in tubal EP, indicating that monocyte activation in the pathophysiology of EP could be effective in the formation of tubal motility and microenvironment regulation.


Assuntos
Gravidez Tubária/sangue , Gravidez Tubária/diagnóstico , Gravidez/sangue , Adulto , Contagem de Células Sanguíneas , Feminino , Humanos , Ativação Plaquetária/fisiologia
11.
Turk Patoloji Derg ; 36(1): 82-86, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-30632126

RESUMO

Tonsillar synovial sarcoma is an extremely rare entity and only 9 adult patients have been reported up to now. Here, we describe the first pediatric tonsillar synovial sarcoma of the literature in a patient who presented with a 2-month history of dysphagia and snoring. Clinical and radiological examinations showed that the tumor arose from the right palatine tonsil and narrowed the parapharyngeal space. An incisional biopsy from the palatine tonsil revealed the diagnosis of synovial sarcoma. The patient has underwent total tonsillectomy and received radiotherapy and chemotherapy because of the positive surgical margins. The patient is clinically in good condition and free of tumor 30 months after the initial diagnosis. We achieved a long-term complete remission with a combination of surgery, radiotherapy and chemotherapy in our case. Tonsillar synovial sarcoma should be kept in mind while dealing with tonsillar masses. We can conclude that a multidisciplinary approach is warranted while treating synovial sarcoma with this localization.


Assuntos
Sarcoma Sinovial/patologia , Neoplasias Tonsilares/patologia , Adulto , Transtornos de Deglutição/etiologia , Humanos , Masculino , Sarcoma Sinovial/complicações , Sarcoma Sinovial/terapia , Ronco/etiologia , Neoplasias Tonsilares/complicações , Neoplasias Tonsilares/terapia , Resultado do Tratamento
13.
Adv Clin Exp Med ; 27(3): 357-361, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29533540

RESUMO

BACKGROUND: The modified Misgav-Ladach method (MML) is a minimally invasive cesarean section procedure compared with the classic Pfannenstiel-Kerr (PK) method. OBJECTIVES: The aim of the study was to compare the MML method and the PK method in terms of intraoperative and short-term postoperative outcomes. MATERIAL AND METHODS: This prospective, randomized controlled trial involved 252 pregnant women scheduled for primary emergency or elective cesarean section between October, 2014 and July, 2015. The primary outcome measures were the duration of surgery, extraction time, Apgar score, blood loss, wound complications, and number of sutures used. Secondary outcome measures were the wound infection, time of bowel restitution, visual analogue scale (VAS) scores at 6 h and 24 h after the operation, limitations in movement, and analgesic requirements. At 6 weeks after surgery, the patients were evaluated regarding late complications. RESULTS: There was a significant reduction in total operating and extraction time in the MML group (p < 0.001). Limitations in movement were lower at 24 h after the MML operation, and less analgesic was required in the MML group. There was no difference between the 2 groups in terms of febrile morbidity or the duration of hospitalization. At 6 weeks after the operation, no complaints and no additional complications from the surgery were noted. CONCLUSIONS: The MML method is a minimally invasive cesarean section. In the future, as surgeons' experience increases, MML will likely be chosen more often than the classic PK method.


Assuntos
Cesárea/métodos , Resultado da Gravidez , Analgésicos , Feminino , Humanos , Tempo de Internação , Avaliação de Processos e Resultados em Cuidados de Saúde , Dor Pós-Operatória/epidemiologia , Período Pós-Operatório , Gravidez , Estudos Prospectivos
14.
J Natl Med Assoc ; 98(7): 1193-6, 2006 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16895295

RESUMO

UNLABELLED: LABELED BACKGROUND: Radiotherapy may cause common cutaneous side effects such as acute and chronic radiodermatitis and also rare skin conditions. CASE REPORT: A 42-year-old woman who received radiotherapy for invasive breast carcinoma developed multiple, scaly, rough papules and nodules restricted to treatment fields six months after completion of the treatment. A relapse of the breast cancer and/or seborrheic keratosis was ruled out by histological confirmation of verruca vulgaris. CONCLUSION: We report the first case of verruca vulgaris associated with radiation treatment. Radiotherapists and dermatologists should be aware of this possibility and be able to differentiate it from other skin lesions associated with irradiation.


Assuntos
Neoplasias da Mama/radioterapia , Carcinoma Ductal de Mama/radioterapia , Efeitos da Radiação , Radioterapia Adjuvante/efeitos adversos , Dermatopatias/etiologia , Verrugas/etiologia , Adulto , Terapia Combinada , Feminino , Humanos , Mastectomia Segmentar , Dermatopatias/terapia , Verrugas/terapia
15.
J Natl Med Assoc ; 98(7): 1136-9, 2006 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16895284

RESUMO

OBJECTIVE: To evaluate prospectively the efficacy of a single fraction of high-dose radiotherapy in patients with Kaposi's sarcoma. PATIENTS: Between 1994 and 2004, 47 patients with Kaposi's sarcoma were treated at Hacettepe University, Department of Radiation Oncology. Thirteen (28%) patients received chemotherapy before radiotherapy and were referred due to recurrent or progressive disease or intolerance to chemotherapy. All lesions were treated locally with a 2-3-cm safety margin with 4-6-MeV electron beams. Radiotherapy consisted of a single fraction of 8 Gy in the first four years and 6 Gy thereafter. RESULTS: The male:female ratio was 4:1. The median age was 61 years (range 18-87). Eight out of 47 patients (17%) had an underlying immunocompromised state, and one had a previous diagnosis of Hodgkin's disease. Of 203 fields treated, 51 and 152 fields were treated with 8 Gy and 6 Gy, respectively. Overall response rates (RR) at 12 months for 8- and 6 Gy were 93% and 86%, which were not statistically different. However, the difference between complete RRs at 12 months (93% and 60% for 8 Gy and 6 Gy respectively) was significant (p<0.0001). Progression-free survival and reirradiation rates were not significantly different. Side effects were tolerable in all but three patients with grade 2-3 fibrosis and edema. CONCLUSION: Radiotherapy is an effective mode of treatment for Kaposi's sarcoma, and a single dose of 8 Gy is more effective in terms of complete RR compared to 6 Gy, though overall response and progression-free survival rates were similar.


Assuntos
Doença de Hodgkin/imunologia , Sarcoma de Kaposi/radioterapia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Intervalo Livre de Doença , Feminino , Hospitais de Ensino , Humanos , Hospedeiro Imunocomprometido , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Dosagem Radioterapêutica , Sarcoma de Kaposi/dietoterapia , Resultado do Tratamento , Turquia
16.
J Pathol Transl Med ; 50(3): 225-30, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-27086598

RESUMO

BACKGROUND: The pathogenesis and etiology of endometrial polyps has not been elucidated. In this study, we aimed to examine the pathogenic mechanisms of endometrial polyp development using immunohistochemistry. We evaluated the expression of galectin-3 and cyclooxgenase-2 (COX-2) during the menstrual cycle in premenopausal women with endometrial polyps or normal endometrium. METHODS: Thirty-one patients with endometrial polyps and 50 healthy control patients were included in this study. The levels of expression of COX-2 and galectin-3 were studied by immunohistochemistry. RESULTS: The percentage of COX-2-positive cells and the intensity of COX-2 staining in the endometrium did not vary during the menstrual cycle either in the control group or in patients with endometrial polyps. However, expression of galectin-3 was significantly lower in endometrial polyps and during the proliferative phase of the endometrium compared with the secretory phase. CONCLUSIONS: Our data suggests that the pathogenesis of endometrial polyps does not involve expression of COX-2 or galectin-3.

17.
J Matern Fetal Neonatal Med ; 29(22): 3686-9, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26752270

RESUMO

BACKGROUND: The aim of this study was to determine the relationship of the salivary levels of dehydroepiandrosterone sulfate (DHEA-S) and cortisol with factors related to depression and anxiety in patients with hyperemesis gravidarum (HG). METHODS: Forty patients with a diagnosis of HG were selected for the study and matched with 40 control patients according to body mass index, parity, and age. Symptoms of depression and anxiety were investigated using the Beck Depression Inventory and Beck Anxiety Inventory for Adults, respectively. Saliva samples were collected in the morning and at night and subjected to enzyme-linked immunosorbent assay for the determination of DHEA-S and cortisol levels. RESULTS: We observed a positive correlation between increased levels of depression and anxiety and increased salivary levels of cortisol and DHEA-S in patients with HG. CONCLUSIONS: Salivary cortisol and DHEA-S levels, as well as mood disorders, should be monitored in patients with HG, although further large, prospective studies are needed to confirm our results.


Assuntos
Ansiedade/etiologia , Sulfato de Desidroepiandrosterona/metabolismo , Depressão/etiologia , Hidrocortisona/metabolismo , Hiperêmese Gravídica/psicologia , Saliva/metabolismo , Adulto , Ansiedade/diagnóstico , Ansiedade/metabolismo , Biomarcadores/metabolismo , Estudos de Casos e Controles , Depressão/diagnóstico , Depressão/metabolismo , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Hiperêmese Gravídica/metabolismo , Gravidez , Estudos Prospectivos
18.
Eur J Endocrinol ; 174(4): 415-23, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-26701868

RESUMO

OBJECTIVE: Osteopontin (OPN) is a multi-functional secreted glycoprotein that plays a crucial role in glucose metabolism and inflammatory process. Growing evidence suggests that there is a link between OPN and ovarian function. However, no such link has yet been found for OPN in polycystic ovary syndrome (PCOS). Our aim was to ascertain whether circulating OPN levels are altered in women with PCOS and to determine whether OPN levels differ between the follicular phase and mid-cycle of the menstrual cycle in eumenorrheic women. DESIGN AND METHODS: In total, 150 women with PCOS and 150 age- and BMI-matched controls without PCOS were recruited for this prospective observational study. OPN levels were measured using ELISA. Metabolic parameters were also determined. RESULTS: Circulating OPN levels were significantly elevated in PCOS women compared with controls (69.12±31.59  ng/ml vs 42.66±21.28  ng/ml; P<0.001). OPN levels were significantly higher at mid-cycle than in the follicular phase in eumenorrheic women. OPN was positively correlated with BMI, homeostasis model assessment of insulin resistance (HOMA-IR), free testosterone, and high sensitivity C-reactive protein (hs-CRP). Multivariate logistic regression analyses revealed that the odds ratio (OR) for PCOS was 3.64 for patients in the highest quartile of OPN compared with those in the lowest quartile (OR=3.64; 95% CI=2.42-5.57; P=0.011). Our findings indicate that BMI, HOMA-IR, hs-CRP, and free testosterone are independent factors influencing serum OPN levels and that OPN is an independent predictor for HOMA-IR. CONCLUSION: PCOS is associated with increased OPN levels.


Assuntos
Osteopontina/sangue , Síndrome do Ovário Policístico/sangue , Adulto , Índice de Massa Corporal , Proteína C-Reativa/análise , Estudos de Casos e Controles , Feminino , Humanos , Resistência à Insulina , Lipídeos/sangue , Ciclo Menstrual/sangue , Síndrome do Ovário Policístico/epidemiologia , Testosterona/sangue , Adulto Jovem
19.
Ital J Anat Embryol ; 120(2): 83-8, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-27086438

RESUMO

Holoprosencephaly is a brain malformation that develops as a result of a defect in development of prosencephalon during early gestation. Holoprosencephaly can be diagnosed with prenatal ultrasonography and magnetic resonance imaging. We report herein a case with cyclopia and holoprosencephaly detected by prenatal ultrasonography.


Assuntos
Holoprosencefalia/diagnóstico por imagem , Adulto , Face/patologia , Feminino , Holoprosencefalia/genética , Holoprosencefalia/patologia , Humanos , Recém-Nascido , Masculino , Gravidez , Ultrassonografia Pré-Natal
20.
Turk Patoloji Derg ; 31(3): 215-8, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-24715550

RESUMO

Malignant transformation of a benign cystic teratoma of the ovary is only rarely seen. A review of the English literature revealed no reports of a malignant melanoma developing from concurrent primary endometrial carcinoma and ovarian cystic teratoma. We report herein a 54-year-old nulliparous woman who underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy for a pelvic mass and was diagnosed by histopathological examination to have a malignant melanoma developing from concurrent primary endometrial carcinoma and ovarian cystic teratoma. No foci of primary malignant melanoma except for the ovary were found upon clinical examination. The patient received postoperative interferon alpha 2B and radiotherapy. She was still asymptomatic at 12 months of follow-up.


Assuntos
Carcinoma/patologia , Neoplasias do Endométrio/patologia , Melanoma/secundário , Neoplasias Císticas, Mucinosas e Serosas/patologia , Neoplasias Primárias Múltiplas , Neoplasias Ovarianas/patologia , Teratoma/patologia , Carcinoma/terapia , Quimiorradioterapia Adjuvante , Neoplasias do Endométrio/terapia , Feminino , Procedimentos Cirúrgicos em Ginecologia , Humanos , Melanoma/terapia , Pessoa de Meia-Idade , Neoplasias Císticas, Mucinosas e Serosas/terapia , Neoplasias Ovarianas/terapia , Teratoma/terapia , Tomografia Computadorizada por Raios X , Resultado do Tratamento
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