Detalhe da pesquisa
1.
Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.
PLoS Biol
; 16(4): e1002628, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29664898
2.
Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.
PLoS Biol
; 15(3): e2001882, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28323820
3.
Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4.
Proc Natl Acad Sci U S A
; 112(12): E1414-22, 2015 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25775568
4.
A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry.
Rapid Commun Mass Spectrom
; 29(22): 2175-83, 2015 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-26467230
5.
Chemoproteomic analysis of intertissue and interspecies isoform diversity of AMP-activated protein kinase (AMPK).
J Biol Chem
; 288(50): 35904-12, 2013 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24187138
6.
Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1.
J Neurochem
; 128(4): 561-76, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24117733
7.
A continuous and direct assay to monitor leucine-rich repeat kinase 2 activity.
Anal Biochem
; 450: 63-9, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24463014
8.
Unexpected mucin-type O-glycosylation and host-specific N-glycosylation of human recombinant interleukin-17A expressed in a human kidney cell line.
Protein Expr Purif
; 87(1): 27-34, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23069765
9.
Deconstruction of activity-dependent covalent modification of heme in human neutrophil myeloperoxidase by multistage mass spectrometry (MS(4)).
Biochemistry
; 51(10): 2065-77, 2012 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22352991
10.
Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.
J Pharmacol Exp Ther
; 341(2): 396-409, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22328573
11.
Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs.
Drug Metab Dispos
; 40(9): 1686-97, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22645092
12.
Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia.
Nat Struct Mol Biol
; 14(5): 413-9, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17435765
13.
Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules.
Nat Struct Mol Biol
; 14(2): 106-13, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17237796
14.
Distinctive attributes of ß-lactam target proteins in Acinetobacter baumannii relevant to development of new antibiotics.
J Am Chem Soc
; 133(50): 20536-45, 2011 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22050378
15.
Initiation of translation at an upstream non-AUG codon accounting for N-terminally extended minor forms of recombinant proteins expressed in insect cells.
Protein Expr Purif
; 76(1): 72-8, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20888915
16.
Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014.
J Pharmacol Exp Ther
; 334(1): 269-77, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20363853
17.
Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase.
Protein Expr Purif
; 73(2): 189-97, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20451617
18.
Binding to the low-density lipoprotein receptor accelerates futile catalytic cycling in PCSK9 and raises the equilibrium level of intramolecular acylenzyme.
Biochemistry
; 48(13): 2941-9, 2009 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-19222187
19.
Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals.
J Pharmacol Exp Ther
; 326(3): 801-8, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18577702
20.
Biophysical and biochemical approach to locating an inhibitor binding site on cholesteryl ester transfer protein.
Bioconjug Chem
; 19(8): 1604-13, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18646836