Detalhe da pesquisa
1.
Novel quinazolinone Derivatives: Design, synthesis and in vivo evaluation as potential agents targeting Alzheimer disease.
Bioorg Chem
; 143: 107065, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38150939
2.
New quinazolinone-based derivatives as DHFR/EGFR-TK inhibitors: Synthesis, molecular modeling simulations, and anticancer activity.
Arch Pharm (Weinheim)
; 356(1): e2200417, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36257809
3.
Design, synthesis and anti-Mycobacterium tuberculosis evaluation of new thiazolidin-4-one and thiazolo[3,2-a][1,3,5]triazine derivatives.
Bioorg Chem
; 124: 105807, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35487073
4.
Design and synthesis of novel 4-fluorobenzamide-based derivatives as promising anti-inflammatory and analgesic agents with an enhanced gastric tolerability and COX-inhibitory activity.
Bioorg Chem
; 115: 105253, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34390973
5.
Design, synthesis and in silico insights of new 7,8-disubstituted-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione derivatives with potent anticancer and multi-kinase inhibitory activities.
Bioorg Chem
; 107: 104569, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33387732
6.
Synthesis, in vitro anticancer activity and in silico studies of certain pyrazole-based derivatives as potential inhibitors of cyclin dependent kinases (CDKs).
Bioorg Chem
; 116: 105347, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34555628
7.
3-Methyl-imidazo[2,1-b]thiazole derivatives as a new class of antifolates: Synthesis, in vitro/in vivo bio-evaluation and molecular modeling simulations.
Bioorg Chem
; 115: 105205, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34329992
8.
Nanomolar potency of imidazo[2,1-b]thiazole analogs as indoleamine 2,3-dioxygenase inhibitors.
Arch Pharm (Weinheim)
; 354(11): e2100202, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34313342
9.
1,2,4-Trisubstituted imidazolinones with dual carbonic anhydrase and p38 mitogen-activated protein kinase inhibitory activity.
Bioorg Chem
; 82: 109-116, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30312865
10.
Synthesis, biological evaluation and molecular modeling study of new (1,2,4-triazole or 1,3,4-thiadiazole)-methylthio-derivatives of quinazolin-4(3H)-one as DHFR inhibitors.
Bioorg Chem
; 72: 282-292, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28499189
11.
Insight on Some Newly Synthesized Trisubstituted Imidazolinones as VEGFR-2 Inhibitors.
ACS Med Chem Lett
; 15(6): 892-898, 2024 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38894896
12.
Discovery of a new potent oxindole multi-kinase inhibitor among a series of designed 3-alkenyl-oxindoles with ancillary carbonic anhydrase inhibitory activity as antiproliferative agents.
BMC Chem
; 17(1): 81, 2023 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37461110
13.
Insights into targeting SARS-CoV-2: design, synthesis, in silico studies and antiviral evaluation of new dimethylxanthine derivatives.
RSC Med Chem
; 14(5): 899-920, 2023 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37252103
14.
Design and synthesis of ciprofloxacin-sulfonamide hybrids to manipulate ciprofloxacin pharmacological qualities: Potency and side effects.
Eur J Med Chem
; 228: 114021, 2022 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34871841
15.
Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive molecular dynamics simulation and in vitro investigation.
Eur J Med Chem
; 241: 114629, 2022 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35961070
16.
Synthesis and computational studies of novel fused pyrimidinones as a promising scaffold with analgesic, anti-inflammatory and COX inhibitory potential.
Eur J Med Chem
; 224: 113682, 2021 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34245948
17.
Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance.
RSC Adv
; 11(58): 36459-36482, 2021 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35494393
18.
Mechanistic selectivity investigation and 2D-QSAR study of some new antiproliferative pyrazoles and pyrazolopyridines as potential CDK2 inhibitors.
Eur J Med Chem
; 218: 113389, 2021 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33784602
19.
Anti-hepatitis-C virus activity and QSAR study of certain thiazolidinone and thiazolotriazine derivatives as potential NS5B polymerase inhibitors.
Eur J Med Chem
; 184: 111747, 2019 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31604164
20.
Identification of some benzoxazepines as anticancer agents inducing cancer cell apoptosis.
Future Med Chem
; 10(14): 1649-1664, 2018 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29957068