Detalhe da pesquisa
1.
Hypocretin/Orexin Interactions with Norepinephrine Contribute to the Opiate Withdrawal Syndrome.
J Neurosci
; 42(2): 255-263, 2022 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34853083
2.
Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation.
J Biol Chem
; 298(4): 101750, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35216969
3.
Translation of circHGF RNA encodes an HGF protein variant promoting glioblastoma growth through stimulation of c-MET.
J Neurooncol
; 163(1): 207-218, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-37162666
4.
Targeting the YAP-TEAD interaction interface for therapeutic intervention in glioblastoma.
J Neurooncol
; 152(2): 217-231, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-33511508
5.
Repurposing Potential of Riluzole as an ITAF Inhibitor in mTOR Therapy Resistant Glioblastoma.
Int J Mol Sci
; 21(1)2020 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31948038
6.
The protein arginine methyltransferase PRMT5 confers therapeutic resistance to mTOR inhibition in glioblastoma.
J Neurooncol
; 145(1): 11-22, 2019 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-31473880
7.
Mechanistic Target of Rapamycin (mTOR) Inhibition Synergizes with Reduced Internal Ribosome Entry Site (IRES)-mediated Translation of Cyclin D1 and c-MYC mRNAs to Treat Glioblastoma.
J Biol Chem
; 291(27): 14146-14159, 2016 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27226604
8.
Structure-activity relationship study of small molecule inhibitors of the DEPTOR-mTOR interaction.
Bioorg Med Chem Lett
; 27(20): 4714-4724, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28916338
9.
Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness.
J Biol Chem
; 290(32): 19387-401, 2015 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25998128
10.
The PP242 mammalian target of rapamycin (mTOR) inhibitor activates extracellular signal-regulated kinase (ERK) in multiple myeloma cells via a target of rapamycin complex 1 (TORC1)/eukaryotic translation initiation factor 4E (eIF-4E)/RAF pathway and activation is a mechanism of resistance.
J Biol Chem
; 287(26): 21796-805, 2012 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22556409
11.
m6A-modification of cyclin D1 and c-myc IRESs in glioblastoma controls ITAF activity and resistance to mTOR inhibition.
Cancer Lett
; 562: 216178, 2023 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37061119
12.
Cellular protection from H2O2 toxicity by Fv-Hsp70: protection via catalase and gamma-glutamyl-cysteine synthase.
Cell Stress Chaperones
; 28(4): 429-439, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37171750
13.
IL-6-induced enhancement of c-Myc translation in multiple myeloma cells: critical role of cytoplasmic localization of the rna-binding protein hnRNP A1.
J Biol Chem
; 286(1): 67-78, 2011 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-20974848
14.
Phosphomimetic substitution of heterogeneous nuclear ribonucleoprotein A1 at serine 199 abolishes AKT-dependent internal ribosome entry site-transacting factor (ITAF) function via effects on strand annealing and results in mammalian target of rapamycin complex 1 (mTORC1) inhibitor sensitivity.
J Biol Chem
; 286(18): 16402-13, 2011 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-21454539
15.
Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor.
Blood
; 116(22): 4560-8, 2010 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20686120
16.
Critical Role for Cap-Independent c-MYC Translation in Progression of Multiple Myeloma.
Mol Cancer Ther
; 21(4): 502-510, 2022 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35086951
17.
mTORC2-mediated direct phosphorylation regulates YAP activity promoting glioblastoma growth and invasive characteristics.
Neoplasia
; 23(9): 951-965, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34343821
18.
Regulation of D-cyclin translation inhibition in myeloma cells treated with mammalian target of rapamycin inhibitors: rationale for combined treatment with extracellular signal-regulated kinase inhibitors and rapamycin.
Mol Cancer Ther
; 8(1): 83-93, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19139116
19.
Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma.
PLoS One
; 14(2): e0212160, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30726300
20.
A Novel Therapeutic Induces DEPTOR Degradation in Multiple Myeloma Cells with Resulting Tumor Cytotoxicity.
Mol Cancer Ther
; 18(10): 1822-1831, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31395691