Detalhe da pesquisa
1.
Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection.
Cell
; 163(5): 1108-1123, 2015 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26582131
2.
The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state.
Mol Cell
; 81(17): 3496-3508.e5, 2021 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34380015
3.
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2.
Proc Natl Acad Sci U S A
; 120(2): e2212931120, 2023 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36598939
4.
Two distinct classes of cochaperones compete for the EEVD motif in heat shock protein 70 to tune its chaperone activities.
J Biol Chem
; 298(3): 101697, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35148989
5.
Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States.
J Am Chem Soc
; 2023 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36753572
6.
Allosteric inhibition of HSP70 in collaboration with STUB1 augments enzalutamide efficacy in antiandrogen resistant prostate tumor and patient-derived models.
Pharmacol Res
; 189: 106692, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36773708
7.
The interactions of molecular chaperones with client proteins: why are they so weak?
J Biol Chem
; 297(5): 101282, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34624315
8.
Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism.
J Biol Chem
; 296: 100613, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33798554
9.
Individualized management of genetic diversity in Niemann-Pick C1 through modulation of the Hsp70 chaperone system.
Hum Mol Genet
; 29(1): 1-19, 2020 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31509197
10.
Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells.
Int J Mol Sci
; 23(3)2022 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35162987
11.
Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases.
Nat Chem Biol
; 15(8): 786-794, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31320752
12.
Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels.
Bioorg Med Chem Lett
; 41: 128025, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33839251
13.
Chemical validation of a druggable site on Hsp27/HSPB1 using in silico solvent mapping and biophysical methods.
Bioorg Med Chem
; 34: 115990, 2021 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33549906
14.
Inhibitors and chemical probes for molecular chaperone networks.
J Biol Chem
; 294(6): 2151-2161, 2019 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30213856
15.
Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation.
J Biol Chem
; 294(50): 18952-18966, 2019 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31578281
16.
Luminescence complementation assay for measurement of binding to protein C-termini in live cells.
Anal Biochem
; 611: 113947, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32918866
17.
Neutral analogs of the heat shock protein 70 (Hsp70) inhibitor, JG-98.
Bioorg Med Chem Lett
; 30(5): 126954, 2020 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31952963
18.
Differential scanning fluorimetry (DSF) screen to identify inhibitors of Hsp60 protein-protein interactions.
Org Biomol Chem
; 18(22): 4157-4163, 2020 06 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32458889
19.
SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.
J Neurosci
; 38(15): 3680-3688, 2018 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29540553
20.
The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein.
J Biol Chem
; 293(27): 10796-10809, 2018 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29764935