Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros

Base de dados
Ano de publicação
Tipo de documento
País de afiliação
Intervalo de ano de publicação
1.
Alzheimers Dement ; 20(2): 769-782, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-37776210

RESUMO

INTRODUCTION: The U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER) is conducted to confirm and expand the results of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) in Americans. METHODS: U.S. POINTER was planned as a 2-year randomized controlled trial of two lifestyle interventions in 2000 older adults at risk for dementia due to well-established factors. The primary outcome is a global cognition composite that permits harmonization with FINGER. RESULTS: U.S. POINTER is centrally coordinated and conducted at five clinical sites (ClinicalTrials.gov: NCT03688126). Outcomes assessments are completed at baseline and every 6 months. Both interventions focus on exercise, diet, cognitive/social stimulation, and cardiovascular health, but differ in intensity and accountability. The study partners with a worldwide network of similar trials for harmonization of methods and data sharing. DISCUSSION: U.S. POINTER is testing a potentially sustainable intervention to support brain health and Alzheimer's prevention for Americans. Impact is strengthened by the targeted participant diversity and expanded scientific scope through ancillary studies.


Assuntos
Disfunção Cognitiva , Humanos , Idoso , Disfunção Cognitiva/psicologia , Estilo de Vida , Cognição , Exercício Físico , Encéfalo
2.
Public Health Nutr ; 13(10): 1581-6, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-20025830

RESUMO

OBJECTIVE: We evaluated the effects of peanut consumption on lipid profiles, atherogenic index of plasma (AIP) and CHD risk in hypercholesterolaemic men. DESIGN: Randomised crossover clinical trial. SETTING: Participants were randomly assigned to two groups. They were asked to consume peanut supplements (about 77 g) with their habitual diet for 4 weeks. SUBJECTS: Fifty-four hypercholesterolaemic men with total cholesterol (TC) concentrations between 200 and 350 mg/dl. RESULTS: Compared with the habitual diet, peanut supplementation of the habitual diet significantly reduced TC/HDL cholesterol (HDL-C) ratio (mean 1 (se 0.3) P = 0.001) and LDL cholesterol (LDL-C)/HDL-C ratio (mean 0.7 (se 0.2); P = 0.001). Peanut consumption increased HDL-C (mean 6.1 (se 1.5) mg/dl; P < 0.001) and total antioxidant capacity (TAC) (mean 1.2 (se 0.6) U/mL P = 0.04). In addition, peanut consumption significantly reduced the AIP (mean 0.1 (se 0.03) P = 0.01) and CHD estimated risk over 10 years based on systolic and diastolic blood pressures (mean 1.4 % (se 0.5 %) P = 0.004 and mean 2.2 % (se 0.5 %) P < 0.001, respectively). CONCLUSIONS: Short-term peanut consumption might improve lipid profiles, the AIP and CHD risk in free-living hypercholesterolaemic men.


Assuntos
Antioxidantes/metabolismo , Arachis , Aterosclerose/prevenção & controle , Doenças Cardiovasculares/prevenção & controle , Colesterol/sangue , Hipercolesterolemia/dietoterapia , Preparações de Plantas/uso terapêutico , Adulto , Aterosclerose/sangue , Pressão Sanguínea/efeitos dos fármacos , Doenças Cardiovasculares/etiologia , Estudos Cross-Over , Suplementos Nutricionais , Humanos , Hipercolesterolemia/sangue , Masculino , Fitoterapia , Preparações de Plantas/farmacologia , Fatores de Risco , Sementes
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA