RESUMO
PURPOSE: A systematic review of randomized clinical trials (RCTs) was undertaken to assess the effectiveness of medical treatment for metastatic breast cancer. METHODS: RCTs published between 1975 and 1997 have been classified according to 12 therapeutic comparisons: (1) polychemotherapy (PCHT) agents versus single agent; (2) PCHT regimens with anthracycline versus PCHT without anthracycline; (3) other PCHT versus cyclophosphamide, methotrexate, and fluorouracil (CMF); (4) chemotherapy (CHT) with epirubicin versus CHT with doxorubicin; (5) CHT versus same CHT delivered with less intensive schedules; (6) other endocrine therapy (OET) versus tamoxifen; (7) OET plus tamoxifen versus tamoxifen alone; (8) OET versus medroxyprogesterone; (9) OET versus aromatase inhibitors; (10) OET versus megestrol; (11) endocrine therapy (ET) versus same ET at lower doses; and (12) CHT plus ET versus CHT. Tumor response rates, mortality hazards ratio (HR) and frequency of severe side effects were the outcome measures. RESULTS: A total of 189 eligible trials (31,510 patients) were identified. All provided response rates and 133 (70%) data or survival curves needed for calculation of the HR. In eight of 12 comparisons, statistically significant differences for response emerged (1, 2, 3, 5, 7, 8, 11, 12); all but no. 8 favored the first term of the comparison. Overall survival analysis showed better results of (a) PCHT versus single-agent CHT (HR=0.82; 95% confidence interval [CI], 0.75 to 0.90); (b) CHT with doxorubicin versus CHT with epirubicin (HR=1.13; 95% CI, 1.00 to 1.27); (c) CHT versus the same CHT delivered with less intensive schedules (HR=0.90; 95% CI, 0.83 to 0.97); (d) ET versus the same ET at lower doses (HR=0.86; 95% CI, 0.77 to 0.97). Quality of life was measured in only 2,995 of 31,510 patients (9.5%). CONCLUSION: Despite some evidence of effectiveness of specific regimens, the relevance of these findings is limited by the modest survival benefit and the lack of evaluation of the quality-of-life impact of these treatments.
Assuntos
Antineoplásicos/uso terapêutico , Neoplasias da Mama/tratamento farmacológico , Ensaios Clínicos Controlados Aleatórios como Assunto , Antibióticos Antineoplásicos/uso terapêutico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Inibidores da Aromatase , Neoplasias da Mama/patologia , Feminino , Fluoruracila/uso terapêutico , Humanos , Acetato de Medroxiprogesterona/uso terapêutico , Megestrol/uso terapêutico , Prednisona/uso terapêutico , Análise de Sobrevida , Tamoxifeno/uso terapêuticoRESUMO
We report nasopharyngeal angiofibroma in a 13 year old boy treated with embolization, surgical excision and radiotherapy, which recurred 13 years later. No features of sarcomatous transformation were found, but the tumor had a locally aggressive course, possibly due to the HIV-positivity of the patient who then died of AIDS. The relations between the clinical course of the tumor and severe immunodeficiency are discussed.
Assuntos
Angiofibroma/complicações , Soropositividade para HIV/complicações , Neoplasias Nasofaríngeas/complicações , Recidiva Local de Neoplasia , Adolescente , Angiofibroma/terapia , Evolução Fatal , Infecções por HIV/complicações , Infecções por HIV/terapia , Humanos , Masculino , Neoplasias Nasofaríngeas/terapia , Recidiva Local de Neoplasia/complicações , Recidiva Local de Neoplasia/terapiaRESUMO
We report a case of cystadenocarcinoma occurring in a pregnant woman. After child birth, a subtotal pancreatectomy was performed, without rupture of the cyst. The patient is asymptomatic, 24 months after surgery. The presentation of cystadenocarcinoma in pregnancy has been reported in another single case. The possibility of hormonal dependence is discussed.
Assuntos
Cistadenocarcinoma/etiologia , Neoplasias Hormônio-Dependentes , Neoplasias Pancreáticas/etiologia , Complicações Neoplásicas na Gravidez/etiologia , Adulto , Cistadenocarcinoma/patologia , Feminino , Humanos , Neoplasias Pancreáticas/patologia , Gravidez , Complicações Neoplásicas na Gravidez/patologiaRESUMO
BACKGROUND: Metastatic renal cell carcinoma is a "capricious" tumor. Many prognostic factors have been evaluated, treatment is still controversial, and results are not coincident. METHODS: We reviewed 156 patients with metastatic renal cell carcinoma. Survival from the time of diagnosis was the end point of the study. The influence on survival of age, sex, nephrectomy, disease-free interval, performance status, site and number of metastases was analyzed. Univariate and multivariate analysis were done. Survival according to different therapies was also evaluated. RESULTS: In our study, no nephrectomy, a disease-free interval < 24 months, > 2 metastatic sites and a performance status > 2 proved to be risk factors. According to the number of risk factors, 3 groups of patients were identified (low, intermediate and high risk). We observed 3 kinds of responses to treatments: 1) in untreated patients (n = 48), median overall survival was 6 months, and the 24-month survival rate was 8%; 2) in patients treated with hormone therapy and/or chemotherapy (n = 73), median overall survival was 13 months, and the 24-month survival rate was 24%; 3) in patients treated with interferon and/or interleukin-2 (n = 35), median overall survival was 16 months and the 24-month survival rate was 34%. CONCLUSIONS: Our results are only partially in accordance with those observed by other authors. Risk factors and treatment must be determined in more defined and selected studies.
Assuntos
Carcinoma de Células Renais/terapia , Neoplasias Renais/terapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Análise de Variância , Antineoplásicos/uso terapêutico , Carcinoma de Células Renais/mortalidade , Carcinoma de Células Renais/secundário , Feminino , Humanos , Imunoterapia , Neoplasias Renais/mortalidade , Neoplasias Renais/patologia , Masculino , Pessoa de Meia-Idade , Nefrectomia , Prognóstico , Estudos Retrospectivos , Fatores de Risco , Análise de Sobrevida , Resultado do TratamentoRESUMO
Of 431 patients with gastric cancer observed in our institution, 23 (5.3%) had early gastric cancer (EGC). Macroscopic presentation, histology, depth of invasion, and lymph node involvement were evaluated in all the cases. All patients underwent surgery and an intensive follow-up was performed. Five of the 23 patients progressed, and the risk factors were examined. Histology seemed to be the main prognostic factor in our study, since intestinal type of EGC was associated to a significantly better prognosis. Total gastrectomy is indicated in the proximal localization of EGC, and should perhaps be performed also in cases presenting undifferentiated histology.
Assuntos
Neoplasias Gástricas/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Neoplasias Gástricas/mortalidade , Análise de SobrevidaRESUMO
BACKGROUND: Interleukin-2 therapy is known to cause many biologic effects, which are enhanced by the administration of interferon prior to or immediately after interleukin-2 infusion. Some of these effects could be related to the clinical response. METHODS: Sixteen patients with metastatic renal cell carcinoma were treated with continuous infusion of interleukin-2 plus alpha-2 interferon. Differential leukocyte count and lymphocyte subset evaluation were performed every 3 days during interleukin-2 treatment. At each cycle, the presence of the following antibodies was tested: antithyroid, antinuclear, antiplatelet and antierythrocyte. RESULTS: Fifteen patients were evaluable for response. No complete response was observed. Five patients obtained partial response (33%) and 3 stable disease (20%): 2 of them underwent surgical resection of metastases and obtained complete response. Some of our patients showed a significant increase in eosinophils, CD25+ lymphocytes and antithyroid antibodies. The association of these parameters, calculated with a "score" system, was also related to a better clinical response. CONCLUSIONS: Eosinophils, CD25+ lymphocytes and antithyroid antibodies could have a predictive value for the efficacy of interleukin-2 and alpha-2 interferon therapy in metastatic renal cell carcinoma.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Carcinoma de Células Renais/sangue , Carcinoma de Células Renais/tratamento farmacológico , Neoplasias Renais/sangue , Neoplasias Renais/tratamento farmacológico , Adulto , Idoso , Anticorpos Antinucleares/sangue , Anticorpos Antineoplásicos/sangue , Autoanticorpos/sangue , Plaquetas/imunologia , Carcinoma de Células Renais/imunologia , Carcinoma de Células Renais/secundário , Eritrócitos/imunologia , Feminino , Humanos , Interferon-alfa/administração & dosagem , Interleucina-2/administração & dosagem , Neoplasias Renais/imunologia , Neoplasias Renais/patologia , Contagem de Leucócitos , Subpopulações de Linfócitos , Masculino , Pessoa de Meia-Idade , Glândula Tireoide/imunologiaAssuntos
Adenocarcinoma/cirurgia , Neoplasias do Apêndice/cirurgia , Adenocarcinoma/diagnóstico , Adulto , Idoso , Apendicectomia , Neoplasias do Apêndice/diagnóstico , Apendicite/complicações , Colectomia , Feminino , Lateralidade Funcional , Humanos , Masculino , Pessoa de Meia-Idade , Cuidados Pré-OperatóriosAssuntos
Abscesso/tratamento farmacológico , Asma/tratamento farmacológico , Quimotripsina/uso terapêutico , Dermatite/tratamento farmacológico , Otite/tratamento farmacológico , Infecções Respiratórias/tratamento farmacológico , Tetraciclina/uso terapêutico , Tromboflebite/tratamento farmacológico , Tripsina/uso terapêutico , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
We report a case of T AILD-like NHL in a 50-year-old man who partially responded to combined therapies. The course of the disease was complicated by a malignant mesenchymal ocular neoplasia. The patient died because of severe infections and lymphoma dissemination. The association between T AILD-like NHL and carcinomas has been described: no case of concomitant malignant mesenchymal neoplasia is reported in literature.
Assuntos
Neoplasias da Túnica Conjuntiva , Linfadenopatia Imunoblástica , Linfoma de Células T , Neoplasias Primárias Múltiplas , Neoplasias Faríngeas , Terapia Combinada , Neoplasias da Túnica Conjuntiva/complicações , Neoplasias da Túnica Conjuntiva/terapia , Humanos , Linfadenopatia Imunoblástica/complicações , Ceratite Herpética/complicações , Linfoma de Células T/complicações , Linfoma de Células T/patologia , Linfoma de Células T/terapia , Masculino , Pessoa de Meia-Idade , Neoplasias Faríngeas/complicações , Neoplasias Faríngeas/patologia , Neoplasias Faríngeas/terapia , Pneumonia Viral/etiologia , Sepse/etiologia , Staphylococcus epidermidisRESUMO
Lee's histochemical method was used to assess hormonal receptors in 1,005 patients with breast cancer. Patients were from 8 oncological departments in northern Italy. The group was subdivided into four subgroups in relation to menopausal status and presence or absence of axillary node metastasis. Overall survival (OS) and disease-free survival (DFS) were analysed in all subgroups in relation to receptorial status. We observed: (1) when hormonal receptors are present, OS and DFS are longer in all subgroups; (2) the presence of hormonal receptors influences favourably both DFS and OS, but it seems to play a more important role for DFS; (3) the positive receptorial status is a better prognostic factor in groups without axillary node metastasis, especially in premenopausal patients. We conclude that the histochemical assessment of hormonal receptors is a valid method for the prognostic evaluation of patients with breast cancer.