Detalhe da pesquisa
1.
A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat.
Biomarkers
; 22(5): 461-469, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-27978773
2.
Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts.
Liver Int
; 34(3): 367-78, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24118944
3.
Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes.
Arch Toxicol
; 88(7): 1427-37, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24912781
4.
hERG-toxicity prediction using traditional machine learning and advanced deep learning techniques.
Curr Res Toxicol
; 5: 100121, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37701072
5.
Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa.
J Med Chem
; 66(2): 1380-1425, 2023 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36634346
6.
New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus.
J Med Chem
; 66(6): 3968-3994, 2023 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36877255
7.
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nat Cancer
; 3(2): 156-172, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35228749
8.
Proliferative and molecular effects of the dual PPARalpha/gamma agonist tesaglitazar in rat adipose tissues: relevance for induction of fibrosarcoma.
Toxicol Pathol
; 39(2): 325-36, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21270424
9.
The regulatory role of PGC1α-related coactivator in response to drug-induced liver injury.
FASEB Bioadv
; 2(8): 453-463, 2020 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-32821877
10.
A systems biology approach to understanding elevated serum alanine transaminase levels in a clinical trial with ximelagatran.
Biomarkers
; 14(8): 572-86, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19780643
11.
Detection of the mitochondrial and catalytically active alanine aminotransferase in human tissues and plasma.
Int J Mol Med
; 23(5): 621-31, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19360321
12.
PPARdelta increases expression of the human apolipoprotein A-II gene in human liver cells.
Int J Mol Med
; 21(6): 819-24, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18506377
13.
Prediction of drug-induced liver injury in humans by using in vitro methods: the case of ximelagatran.
Toxicol In Vitro
; 22(3): 730-46, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18191936
14.
Differential expression of peroxisomal proliferator activated receptors alpha and delta in skeletal muscle in response to changes in diet and exercise.
Int J Mol Med
; 17(1): 45-52, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16328010
15.
The peroxisome proliferator-activated receptor α agonist, AZD4619, induces alanine aminotransferase-1 gene and protein expression in human, but not in rat hepatocytes: Correlation with serum ALT levels.
Int J Mol Med
; 38(3): 961-8, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27430334
16.
Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans.
Int J Mol Med
; 30(5): 1241-9, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22922605
17.
PPARalpha regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes.
Toxicol Appl Pharmacol
; 231(1): 1-9, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18455211
18.
Isoforms of alanine aminotransferases in human tissues and serum--differential tissue expression using novel antibodies.
Arch Biochem Biophys
; 466(1): 66-77, 2007 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17826732
19.
PPARdelta activation induces COX-2 gene expression and cell proliferation in human hepatocellular carcinoma cells.
Biochem Biophys Res Commun
; 308(2): 361-8, 2003 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-12901877