Detalhe da pesquisa
1.
Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria.
Nat Commun
; 15(1): 2005, 2024 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38443338
2.
Synthesis of MDM2-p53 Inhibitor BI-0282 via a Dipolar Cycloaddition and Late-Stage Davis-Beirut Reaction.
Org Process Res Dev
; 26(8): 2526-2531, 2022 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36032359
3.
A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo.
Nat Commun
; 13(1): 5969, 2022 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36216795
4.
Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor.
J Med Chem
; 65(21): 14614-14629, 2022 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36300829
5.
Targeted Synthesis of Complex Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2-p53 Inhibitors.
ChemMedChem
; 14(1): 88-93, 2019 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30458062