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MXenes have demonstrated significant potential in electrochemical energy storage, particularly in supercapacitors, owing to their exceptional properties. The surface terminal groups of MXene play a pivotal role in pseudocapacitive mechanism. Considering the hindered electrolyte ion transport caused by -F terminal groups and the limited ion binding sites associated with -O terminal groups, this study proposes a novel strategy of replacing -F with -N terminal groups. The modulated MXene-N electrode, featuring a substantial number of -N terminal groups, demonstrates an exceptionally high gravimetric capacitance of 566 F g-1 (at a scan rate of 2 mV s-1 ) or 588 F g-1 (at a discharge rate of 1 A g-1 ) in 1 м H2 SO4 electrolyte, and the potential window is significantly increased. Furthermore, subsequent spectra analysis and density functional theory calculations are employed to investigate the mechanism associated with -N terminal groups. This work exemplifies the significance of terminal modulation in the context of electrochemical energy storage.
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Hypertension is the primary disease that endangers human health. A convenient and accurate blood pressure measurement method can help to prevent the hypertension. This paper proposed a continuous blood pressure measurement method based on facial video signal. Firstly, color distortion filtering and independent component analysis were used to extract the video pulse wave of the region of interest in the facial video signal, and the multi-dimensional feature extraction of the pulse wave was preformed based on the time-frequency domain and physiological principles; Secondly, an integrated feature selection method was designed to extract the universal optimal feature subset; After that, we compared the single person blood pressure measurement models established by Elman neural network based on particle swarm optimization, support vector machine (SVM) and deep belief network; Finally, we used SVM algorithm to build a general blood pressure prediction model, which was compared and evaluated with the real blood pressure value. The experimental results showed that the blood pressure measurement results based on facial video were in good agreement with the standard blood pressure values. Comparing the estimated blood pressure from the video with standard blood pressure value, the mean absolute error (MAE) of systolic blood pressure was 4.9 mm Hg with a standard deviation (STD) of 5.9 mm Hg, and the MAE of diastolic blood pressure was 4.6 mm Hg with a STD of 5.0 mm Hg, which met the AAMI standards. The non-contact blood pressure measurement method based on video stream proposed in this paper can be used for blood pressure measurement.
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Determinação da Pressão Arterial , Hipertensão , Humanos , Algoritmos , Pressão Sanguínea/fisiologia , Determinação da Pressão Arterial/métodos , Hipertensão/diagnósticoRESUMO
The oxygen evolution reaction (OER) plays a key role in many electrochemical energy conversion systems, but it is a kinetically sluggish reaction and requires a large overpotential to deliver appreciable current, especially for the non-noble metal electrocatalysts. In this study, the authors report a surface phase engineering strategy to improve the OER performance of transition metal nitrides (TMNs). The iron-nickel nitrides/alloy nanospheres (FeNi3 -N) wrapped in carbon are synthesized, and the optimized FeNi3 -N catalyst displays dual-phase nitrides on the surface induced by atom migration phenomenon, resulting from the different migration rates of metal atoms during the nitridation process. It shows excellent OER performance in alkaline media with an overpotential of 222 mV at 10 mA cm-2 , a small Tafel slope of 41.53 mV dec-1 , and long-term durability under high current density (>0.5 A cm-2 ) for at least 36 h. Density functional theory (DFT) calculations further reveal that the dual-phase nitrides are favorable to decrease the energy barrier, modulate the d-band center to balance the absorption and desorption of the intermediates, and thus promote the OER electrochemical performance. This strategy may shed light on designing OER and other catalysts based on surface phase engineering.
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PURPOSE: Identifying factors that place patients at high risk for developing postoperative delirium is an important first step to reduce incidence. Frailty is associated with poor postoperative outcomes. This meta-analysis aims to determine the association between preoperative frailty and postoperative delirium. DESIGN: This is a systematic review and meta-analysis. METHODS: We used PubMed, Scopus, Embase, CINAHL, Cochrane, and Web of Science as databases for the search up to April 23, 2020. We included cohort studies that assessed postoperative delirium as the outcome and described the prevalence of delirium among participants during the postoperative period. Odds ratio and 95% confidence interval were calculated to examine the association. FINDINGS: Twenty cohort studies met our inclusion criteria, which included a total of 4,568 patients. We found that preoperative frailty was significantly associated with an increased risk of postoperative delirium (crude odds ratio: 3.28; 95% confidence interval: 2.51 to 4.28; I2 = 46.7%) (adjusted odds ratio: 2.45; 95% confidence interval: 1.58 to 3.81; I2 = 88.6%). CONCLUSIONS: This meta-analysis showed that preoperative frailty is an independent risk factor for postoperative delirium. In patients undergoing cardiovascular surgery, there is a lower association between frailty and postoperative delirium. In patients with other types of surgery, preoperative frailty is closely related to postoperative delirium.
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Delírio , Fragilidade , Estudos de Coortes , Delírio/epidemiologia , Delírio/etiologia , Fragilidade/complicações , Humanos , Incidência , Complicações Pós-Operatórias/epidemiologia , Fatores de RiscoRESUMO
Major depression disorder is one of the diseases with the highest rate of disability and morbidity and is associated with numerous structural and functional differences in neural systems. However, it is difficult to analyze digital medical imaging data without computational intervention. A voxel-wise densely connected convolutional neural network, Three-dimensional Densenet (3D-DenseNet), is proposed to mine the feature differences. In addition, a novel transfer learning method, called Alzheimer's Disease Neuroimaging Initiative Transfer (ADNI-Transfer), is designed and combined with the proposed 3D-DenseNet. The experimental results on a database that contains 174 subjects, including 99 patients with major depression disorder and 75 healthy controls, show that large changes in brain structures between major depressive disorder patients and healthy controls mainly are located in the regions including superior frontal gyrus, dorsolateral, middle temporal gyrus, middle frontal gyrus, postcentral gyrus, inferior temporal gyrus. In addition, the proposed deep learning network can better extract different features of brain structures between major depressive disorder patients and healthy controls and achieve excellent classification results of major depressive disorder. At the same time, the designed transfer learning method can further improve classification performance. These results verify that our proposed method is feasible and valid for diagnosing and analyzing major depression disorder.
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Córtex Cerebral/diagnóstico por imagem , Aprendizado Profundo , Transtorno Depressivo Maior/diagnóstico por imagem , Imageamento por Ressonância Magnética/métodos , Neuroimagem/métodos , Adulto , Estudos de Viabilidade , Feminino , Humanos , Processamento de Imagem Assistida por Computador/métodos , Processamento de Imagem Assistida por Computador/normas , Imageamento por Ressonância Magnética/normas , Masculino , Pessoa de Meia-Idade , Neuroimagem/normas , Reprodutibilidade dos Testes , Adulto JovemRESUMO
To construct desired metal-organic framework (MOF) sensors, the predesigned functionalized ligands 2,5-bis(2',5'-dicarboxylphenyl)pyridine (L-N) and 2,5-bis(2',5'-dicarboxylphenyl)difluorobenzene (L-F) with pyridine- and fluorine-decorated tetracarboxylic acids were used, and two stable terbium-organic frameworks, H3O[(Tb(L-N)(H2O)2]·2H2O (Tb-N) and [Tb3(L-F)2(HCOO)(H2O)4]·6H2O (Tb-F), have been synthesized. The structures of Tb-N and Tb-F contain 1D open channels, which are functionalized by pyridine N or F atoms, respectively. Both of them show intense fluorescence in water and exhibit excellent selectivity and sensitivity to Fe3+ ions. The effects of different functional group sites on the stability and fluorescence sensing performance of MOFs have also been studied. In addition, a gas adsorption study demonstrates that Tb-N is capable of adsorbing C2H2 over CH4 selectively.
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Transition-metal (TM) phosphides attract increasing attention with applications for energy conversion and storage, due to their outstanding physical, chemical, and electronic properties. The 3d transition metal tetraphosphides (TMP4, TM = V, Cr, Mn, and Fe) possess multiple allotropies and rich electronic properties. Here, we perform the investigations of the structural, electronic, and elastic properties for 3d-TMP4 (TM = V, Cr, Mn, and Fe) using density functional theory (DFT) calculations. These compounds are featured with alternating buckled phosphorus sheets with ten-numbered phosphorus rings and varied transition-metal layers. Hybrid DFT calculations reveal that TMP4 compounds exhibit a wide range of electrical properties, ranging from metallic behavior for VP4 to semiconducting behavior for CrP4 with the narrow direct band gap of 0.63 eV to enlarged semiconducting MnP4 and FeP4 with band gap of 1.6-2.1 eV. The bonding analysis indicates that P-P and TM-P covalent interactions dominate in the phosphorus sheets and TMP6 octahedrons, which are responsible for the structural and electronic diversity.
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Dysregulation of hepatic gluconeogenesis contributes to the pathogenesis of diabetes, yet the detailed molecular mechanisms remain to be fully elucidated. Here we show that FOXP1, a transcriptional repressor, plays a key role in the regulation of systemic glucose homeostasis. Hepatic expression levels of FOXP1 are decreased in diabetic mice. Modest hepatic overexpression of FOXP1 in mice inhibited the expression of gluconeogenic genes, such as peroxisome proliferators-activated receptor γ coactivator-1α (PGC-1α), phosphoenolpyruvate carboxykinase (PEPCK), and glucose-6-phosphatase (G6PC), leading to a decrease in hepatic glucose production and fasting blood glucose levels in normal mice and different mouse models of diabetes, including db/db diabetic and high-fat diet-induced obese mice. FOXP1 physically interacted with FOXO1 in vivo and competed with FOXO1 for binding to the insulin response element in the promoter region of gluconeogenic genes, thereby interfering expression of these genes. These results identify a previously unrecognized role for FOXP1 in the transcriptional control of hepatic glucose homeostasis.
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Fatores de Transcrição Forkhead/metabolismo , Gluconeogênese , Glucose/metabolismo , Homeostase , Fígado/metabolismo , Proteínas Repressoras/metabolismo , Animais , Diabetes Mellitus/genética , Diabetes Mellitus/metabolismo , Gorduras na Dieta/efeitos adversos , Gorduras na Dieta/farmacologia , Fatores de Transcrição Forkhead/genética , Glucose/genética , Masculino , Camundongos , Camundongos Obesos , Obesidade/induzido quimicamente , Obesidade/genética , Obesidade/metabolismo , Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo , Fosfoenolpiruvato Carboxiquinase (GTP) , Proteínas Repressoras/genética , Fatores de Transcrição/genética , Fatores de Transcrição/metabolismoRESUMO
OBJECTIVE: Germinal center kinase-like kinase (GLK; also called MAPKKKK-3) activates protein kinase Cθ (PKCθ) during T cell activation and controls autoimmunity in lupus patients. Intracellular kinases are involved in the pathogenesis of rheumatoid arthritis (RA). We undertook this study to determine the role of GLK in RA. METHODS: The severity of collagen-induced arthritis (CIA) was studied in GLK-deficient mice. Expression levels of GLK from RA patients were determined by Western blotting, flow cytometry, real-time polymerase chain reaction, and immunohistochemical staining. Localization of GLK in T cells was identified by confocal microscopy. RA disease activity was assessed using the Disease Activity Score in 28 joints. RESULTS: GLK-deficient mice displayed impaired CIA development and decreased inflammatory cytokine levels. Local T cell infiltration and collagen restimulation responses were impaired by GLK deficiency. RA patients showed significantly higher GLK protein and messenger RNA levels in peripheral blood T cells than did healthy controls. GLK-overexpressing T cells in synovial fluid and synovial tissue samples from RA patients were increased compared with those from osteoarthritis patients. Confocal microscopy and flow cytometry showed that GLK colocalized and coexisted with phosphorylated PKCθ in T cells from RA patients. Frequencies of GLK-expressing T cells were significantly correlated with RA disease activity. CONCLUSION: GLK overexpression in T cells contributes to the pathogenesis of RA, indicating that GLK is a novel biomarker for autoimmune disease severity and a potential therapeutic target for RA.
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Artrite Experimental/diagnóstico , Artrite Experimental/metabolismo , Artrite Reumatoide/diagnóstico , Artrite Reumatoide/metabolismo , Proteínas Quinases/metabolismo , Linfócitos T/metabolismo , Adulto , Idoso , Animais , Artrite Experimental/patologia , Artrite Reumatoide/patologia , Biomarcadores/metabolismo , Complexo CD3/metabolismo , Estudos de Casos e Controles , Diagnóstico Diferencial , Modelos Animais de Doenças , Feminino , Humanos , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Knockout , Pessoa de Meia-Idade , Osteoartrite/diagnóstico , Osteoartrite/metabolismo , Osteoartrite/patologia , Proteínas Quinases/deficiência , Proteínas Quinases/genética , Índice de Gravidade de Doença , Líquido Sinovial/metabolismo , Membrana Sinovial/metabolismo , Membrana Sinovial/patologia , Linfócitos T/patologiaRESUMO
It has been 16 years since the world's largest Ulva bloom appeared in the Yellow Sea. However, it remains unclear how the floating Ulva prolifera developed into the immense green tide within two months especially considering that source control measures have been conducted since 2019. In this study, we investigated the growth mechanism of the floating population by examining the production and regeneration of U. prolifera explants and constructing a growth model. The results showed that U. prolifera explants exhibited rapid regeneration mainly through branches at 15, 20 and 25 °C. Algivore feeding and sporulation (at 20-25 °C) contributed to mass production of explants. The growth of floating population could be attributed to the coupling of mass production and rapid regeneration of explants through multiple cycles, which accounted for the outbreak of floating green tide. This finding presented a novel population growth model to elucidate macroalgal bloom occurrences.
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Human Maxillary Sinus Membrane Stem Cells (hMSMSCs) contribute significantly to bone formation following maxillary sinus floor augmentation (MSFA). The biological behavior of mesenchymal stem cells is notably influenced by varying concentrations of magnesium (Mg2+), strontium (Sr2+), and zinc (Zn2+) ions; however, their specific effects on hMSMSCs have not been comprehensively studied. We isolated hMSMSCs and identified their mesenchymal stem cell characteristics by flow cytometry and multilineage differentiation experiments. Subsequently, the hMSMSCs were cultured in media containing different concentrations of these metal ions. The proliferation and viability of hMSMSCs were assessed using CCK-8 and Calcein AM/PI staining. After osteogenic induction, cells were evaluated for alkaline phosphatase (ALP) activity, ALP staining, and Alizarin Red staining. Additionally, qRT-PCR was used to detect differences in osteogenic gene expression, and immunofluorescence staining was used to observe variations in OCN protein levels. The results indicated that 1 mM Mg2+, 0.01 mM Sr2+, and 0.001 mM Zn2+ significantly improved the proliferation and activity of hMSMSCs. These concentrations also notably enhanced ALP secretion, increased bone-related gene expression, and augmented osteocalcin expression and formation of extracellular calcium nodules, thereby improving osteogenic differentiation. However, higher concentrations of Mg2+, Sr2+, and Zn2+ decreased cell viability and osteogenic differentiation. Mg2+, Sr2+, and Zn2+ promote osteogenic differentiation and proliferation of hMSMSCs in a concentration-dependent manner, indicating that the type and concentration of ions in the extracellular environment can significantly alter hMSMSCs behavior, which is a crucial consideration for material design in maxillary sinus elevation applications.
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The world's largest green tide, caused by the nuisance green algae Ulva prolifera, has occurred in the southern Yellow Sea for 16 consecutive years. It is puzzling why the extensive floating green tide occurs exclusively in the southern Yellow Sea, rather than other waters. We speculate that the transition of U. prolifera from a sessile state to a surface-floating one is the underlying cause of the floating green tide. Here we founded that the floating of U. prolifera was attributed to detachment from substrata and appropriate desiccation. The convergence of unreasonable green algae disposal, geographical features and farming patterns of Porphyra (economic red algae) in Subei Shoal contributed to mass production of floating U. prolifera, resulting in the exclusive occurrence of the floating green tides. Inducing the natural inactivation of green algae to prevent the floating of U. prolifera may effectively mitigate the extensive Ulva bloom at zero cost.
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Eutrofização , Ulva , Ulva/fisiologia , Oceanos e Mares , Monitoramento Ambiental , China , Clorófitas/fisiologia , Água do MarRESUMO
Peripheral nerve injury (PNI) remains a challenging area in regenerative medicine. Nerve guide conduit (NGC) transplantation is a common treatment for PNI, but the prognosis of NGC treatment is unsatisfactory due to 1) neuromechanical unmatching and 2) the intra-conduit inflammatory microenvironment (IME) resulting from Schwann cell pyroptosis and inflammatory-polarized macrophages. A neuromechanically matched NGC composed of regenerated silk fibroin (RSF) loaded with poly(3,4-ethylenedioxythiophene): poly(styrene sulfonate) (P:P) and dimethyl fumarate (DMF) are designed, which exhibits a matched elastic modulus (25.1 ± 3.5 MPa) for the peripheral nerve and the highest 80% elongation at break, better than most protein-based conduits. Moreover, the NGC can gradually regulate the intra-conduit IME by releasing DMF and monitoring sciatic nerve movements via piezoresistive sensing. The combination of NGC and electrical stimulation modulates the IME to support PNI regeneration by synergistically inhibiting Schwann cell pyroptosis and reducing inflammatory factor release, shifting macrophage polarization from the inflammatory M1 phenotype to the tissue regenerative M2 phenotype and resulting in functional recovery of neurons. In a rat sciatic nerve crush model, NGC promoted remyelination and functional and structural regeneration. Generally, the DMF/RSF/P:P conduit provides a new potential therapeutic approach to promote nerve repair in future clinical treatments.
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Fibroínas , Regeneração Nervosa , Traumatismos dos Nervos Periféricos , Animais , Regeneração Nervosa/efeitos dos fármacos , Regeneração Nervosa/fisiologia , Ratos , Traumatismos dos Nervos Periféricos/terapia , Fibroínas/química , Fibroínas/farmacologia , Modelos Animais de Doenças , Ratos Sprague-Dawley , Células de Schwann/metabolismo , Regeneração Tecidual Guiada/métodos , Inflamação , Alicerces Teciduais/química , Nervo Isquiático/lesõesRESUMO
BACKGROUND & AIMS: Missense mutations in human Krüppel-like factor 11 (KLF11) lead to the development of diabetes, as a result of impaired insulin synthesis in the pancreas. However, the role of KLF11 in peripheral tissues is largely unknown. The aim of this study is to evaluate the role of KLF11 in the regulation of hepatic lipid homeostasis using different mouse models. METHODS: Adenoviruses expressing KLF11 (Ad-KLF11) or KLF11-specific shRNA (Ad-shKLF11) were injected into db/db diabetic, high-fat diet-induced obese (DIO), or normal C57BL/6J mice. Histological analysis of the fatty liver phenotype and biochemical analysis of hepatic and serum TG levels in these mice were performed. The molecular mechanism by which KLF11 regulates lipid metabolism in primary hepatocytes and mouse livers was explored. RESULTS: The expression of the transcription factor KLF11 gene is dysregulated in the livers of db/db and DIO mice. Adenovirus-mediated overexpression of KLF11 in the livers of db/db and DIO mice activates the PPARα signaling pathway, subsequently markedly improving the fatty liver phenotype. Conversely, knockdown of KLF11, by adenovirus (Ad-shKLF11) in livers of wild type C57BL/6J and db/m mice, increases hepatic triglyceride (TG) levels, owing to decreased fatty acid oxidation. Finally, the treatment of diabetic mice with Ad-shPPARα abolishes KLF11 stimulatory effects on the expression of genes involved in fatty acid oxidation and inhibitory effects on hepatic TG content. In contrast, PPARα rescue restores the increased hepatic TG levels in Ad-shKLF11-infected db/m mice to normal levels. CONCLUSIONS: KLF11 is an important regulator of hepatic lipid metabolism.
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Proteínas de Ligação a DNA/metabolismo , Metabolismo dos Lipídeos , Fígado/metabolismo , Fatores de Transcrição/metabolismo , Animais , Proteínas Reguladoras de Apoptose , Proteínas de Ligação a DNA/antagonistas & inibidores , Proteínas de Ligação a DNA/genética , Diabetes Mellitus Tipo 2/genética , Diabetes Mellitus Tipo 2/metabolismo , Regulação da Expressão Gênica , Técnicas de Silenciamento de Genes , Hepatócitos/metabolismo , Humanos , Metabolismo dos Lipídeos/genética , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Mutantes , Camundongos Transgênicos , Estado Nutricional , Obesidade/genética , Obesidade/metabolismo , PPAR alfa/metabolismo , RNA Interferente Pequeno/genética , Proteínas Repressoras , Transdução de Sinais , Fatores de Transcrição/antagonistas & inibidores , Fatores de Transcrição/genética , Triglicerídeos/metabolismoRESUMO
Ten new abietane diterpenoids, aquilarabietic acids A-J (1-10), and a new podocarpane diterpenoid, aquilarabietic acid K (11), were isolated from the petroleum ether and ethanol extracts of Chinese eaglewood. Among them, 3, 9, and 10 are artifacts. Their structures were established on the basis of data from extensive spectroscopic and X-ray diffraction analyses. Bioassay results indicated that 1 at 10 µM demonstrated remarkable antidepressant activity in vitro by inhibiting norepinephrine reuptake in rat brain synaptosomes by 81.4% and with an IC(50) value of 9.1 × 10(-7) M.
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Abietanos/isolamento & purificação , Abietanos/farmacologia , Antidepressivos/isolamento & purificação , Antidepressivos/farmacologia , Medicamentos de Ervas Chinesas/isolamento & purificação , Medicamentos de Ervas Chinesas/farmacologia , Thymelaeaceae/química , Abietanos/química , Animais , Antidepressivos/química , Encéfalo/efeitos dos fármacos , Medicamentos de Ervas Chinesas/química , Masculino , Estrutura Molecular , Norepinefrina/antagonistas & inibidores , Ressonância Magnética Nuclear Biomolecular , Ratos , Sinaptossomos/efeitos dos fármacosRESUMO
Three new unusual 23-spirocholestane derivatives, ypsilanogenin (1), ypsilanogenin 3-O-ß-D-glucopyranoside (2), and 4'-acetylypsilanogenin 3-O-ß-D-glucopyranoside (3), were isolated from the whole plants of Ypsilandra thibetica. The structures of compounds 1-3 were deduced by spectroscopic and chemical methods, and the structure of 1 was further confirmed by a single-crystal diffraction analysis. All isolates were evaluated for their inhibitory activities against HIV-1.
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Fármacos Anti-HIV/farmacologia , Glicosídeos/farmacologia , Liliaceae/química , Fármacos Anti-HIV/química , Fármacos Anti-HIV/isolamento & purificação , Colestanos/química , Colestanos/isolamento & purificação , Colestanos/farmacologia , Cristalografia por Raios X , Glicosídeos/química , Glicosídeos/isolamento & purificação , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Plantas Medicinais , Saponinas/química , Saponinas/isolamento & purificação , Saponinas/farmacologia , Compostos de Espiro/química , Compostos de Espiro/isolamento & purificação , Compostos de Espiro/farmacologiaRESUMO
A new limonoid compound, named evorubodinin (1), was isolated from the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang (family Rutaceae), together with two known limonoid compounds, limonin (2) and evolimorutanin (3). The chemical structure of 1 was elucidated by spectroscopic method and single-crystal X-ray diffraction. The inhibitory effects of the isolated compounds 1-3 and the structurally related compounds evodol (4), shihulimonin A1 (5), evodirutaenin (6), 12α-hydroxyrutaevin (7), and rutaevin (8) on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages were also assayed. All compounds 1-8 showed the inhibitory activity, in which both 7 and 8 with the uncommon 5ß-H configuration more efficiently inhibited NO production. The results provided valuable information for further investigation of compounds 1-8 as anti-inflammatory agents or lead compounds.
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Evodia/química , Limoninas/isolamento & purificação , Limoninas/farmacologia , Lipopolissacarídeos/farmacologia , Macrófagos/efeitos dos fármacos , Óxido Nítrico/antagonistas & inibidores , Animais , Anti-Inflamatórios , Frutas/química , Limoninas/química , Camundongos , Estrutura Molecular , Óxido Nítrico/biossíntese , Triterpenos/químicaRESUMO
BACKGROUND: Gastric duplication cysts are very rare disease that are mainly diagnosed by endoscopic ultrasonographic fine-needle aspiration biopsy. In the past, this disease was usually treated with traditional surgery and rarely with minimally invasive endoscopic surgery. However, minimally invasive endoscopic therapy has many advantages, such as no skin wound, organ preservation, postoperative pain reduction, early food intake, fewer postoperative complications, and shorter post-procedure hospitalization. CASE SUMMARY: We report a case of endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) combined with lauromacrogol sclerotherapy for pyloric obstruction due to gastric duplication cysts. CONCLUSION: EUS-FNA combined with lauromacrogol sclerotherapy provides a new option for the treatment of gastrointestinal duplication cysts.
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Infrared spectra are often corrupted by noise, which may greatly influence the accuracy and precision of the analytical result. To improve the analytical precision, the authors need to denoise the spectrum data first. In the present paper, a spectrum denoising method by the second generation wavelet transform domain thresholding combined with the median filtering is introduced. The spectrum of a certain kind of wheat was used to test the performance of the proposed denoising method. In the experiment,noise with signal to noise ratio 21.17 dB was first added to the spectrum, and then removed by the proposed denoising method. The signal to noise ratio (SNR), the root mean square error (RMSE), the average relative error of the peak value (AREPV) and the average error of the peak position (AEPP) were used to evaluate the performance of the proposed denoising method. Experimental results show that the proposed method can remove the spectrum noise and keep the useful information more effective than Donoho's soft and hard threshold method. At the same time, it can achieve a higher PSNR, a lower RMSE, a lower AREPV and a lower AEPP than the other two denoising methods.
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Finding a desirable sampling estimator has a profound impact on the development of static word embedding models, such as continue-bag-of-words (CBOW) and skip gram (SG), which have been generally accepted as popular low-resource algorithms to generate task-agnostic word representations. Due to the prevalence of large-scale pretrained models, less attention has been paid to these static models in the recent years. However, compared with the dynamic embedding models (e.g., BERT), these static models are straightforward to interpret, cost effective to train, and out-of-box to deploy, thus are still widely used in various downstream models until now. Therefore, it is still of considerable significance to study and improve them, especially the crucial components shared by these static models. In this article, we focus on negative sampling (NS), a key component shared by the sampling-based static models, by investigating and mitigating some critical problems of the sampling core. Concretely, we propose Seeds, a sampling enhanced embedding framework, to learn static word embeddings by a new algorithmic innovation for replacing the NS estimator, in which multifactor global priors are considered dynamically for different training pairs. Then, we implement this framework by four concrete models. For the first two implementations, namely CBOW-GP and SG-GP, both negative words and positive auxiliaries are sampled. And for the other two implementations, CBOW-GN and SG-GN, estimations are simplified by sampling only the negative instances. Extensive experimental results across a variety of standard intrinsic and extrinsic tasks demonstrate that embeddings learned by the proposed models outperform their NS-based counterparts, such as CBOW-NS and SG-NS, as well as other strong baselines.