Status 2 upgrade indication impacts posttransplant mortality in patients bridged with intraaortic balloon pump in the new heart allocation system.

To evaluate outcomes of patients undergoing heart transplants (HTs) using an intra-aortic balloon pump (IABP) under exception status. Adult patients supported by an IABP who underwent HT between November 18, 2018, and December 31, 2020, as documented in the United Network for Organ Sharing, were included. Patients were stratified according to requests for exception status. Kaplan-Meier methodology was used to look for differences in survival between groups. A total of 1284 patients were included; 492 (38.3%) were transplanted with an IABP under exception status. Exception status patients had higher body mass index, were more likely to be Black, and had longer waitlist times. Exception status patients received organs from younger donors, had a shorter ischemic time, and had a higher frequency of sex mismatch. The 1-year posttransplant survival was 93% for the nonexception and 88% for the exception IABP patients (hazard ratio: 1.85 [95% confidence interval: 1.12-2.86, P = .006]). The most common reason for requesting an exception status was inability to meet blood pressure criteria for extension (37% of patients). The most common reason for an extension request for an exception status was right ventricular dysfunction (24%). IABP patients transplanted under exception status have an increased 1-year mortality rate posttransplant compared with those without exception status.

Relationship between Workload, Psychological State and Recovery in Female Soccer Athletes.

This study assessed the multifaceted relations between measures of workload, psychological state, and recovery throughout an entire soccer season in female collegiate soccer athletes (19.8±1.2 yrs, 132±12.3 lbs, 63±3.2 in). A prospective longitudinal study was utilized to measure workload (GPS training load, Rate of Perceived Exertion (RPE), psychological state (mental stress, mental fatigue, and mood), and recovery (sleep duration, sleep quality, and soreness), during 90 observations (59 training sessions and 21 games). Separate linear-mixed effect models were used to assess outcomes of RPE, soreness, and sleep duration. A linear mixed-effects model explained 59% of the variance in RPE following each session. Specifically, each standard deviation increase in GPS load and mental stress in the morning prior to training increased RPE by 1.46 (SE=0.08) and 0.29 (SE=0.07), respectively, following that day's training. Furthermore, a significant interaction was found between several predictor variables and chronological day in the season while predicting RPE. Specifically, for each standard deviation increase in GPS load, RPE went up by 0.0055 per day during the season suggesting that load had a higher impact on RPE as the season progressed. In contrast, the interaction of day by mental stress, sleep duration, and soreness continued to be stronger as the season progressed. Each linear mixed-effect model predicted a larger amount of variance when accounting for individual variations in the random effects.

The Impact of an 8-Week Resisted Sprint Training Program on Ice Skating Performance in Male Youth Ice Hockey Players.

ABSTRACT: Dietze-Hermosa, MS, Montalvo, S, Gonzalez, MP, and Dorgo, S. The impact of an 8-week, resisted, sprint training program on ice skating performance in male youth ice hockey players. J Strength Cond Res 38(5): 957-965, 2024-The purposes of this randomized control study were to (a) compare the effects of an on-ice versus an overground resisted sprint training intervention and a control condition and (b) identify changes in ice skating kinematics and kinetics after training intervention participation. Twenty-four youth ice hockey players were randomly allocated into 3 groups: (a) on-ice resisted sprint training (on-ice RST); (b) overground resisted sprint training (overground RST); and (c) body weight resistance training (control). During the 8-week intervention, the 2 RST groups engaged in sled towing methods, whereas the control group engaged in a body weight resistance training program twice a week. A series of individual, repeated-measures analysis of variances with post hoc pairwise comparisons were conducted for variables of interest. An interaction effect was noted for ice skating s-cornering agility drill completion time ( p = 0.01; ηp2 = 0.36), ice skating 30-m top speed completion time ( p = 0.04; ηp2 = 0.27), step length ( p = 0.04; ηp2 = 0.26), and knee angle at touchdown ( p = 0.03; ηp2 = 0.30). The on-ice RST group displayed superior improvements across ice skating tests compared with the control group. Data show that on-ice RST has the greatest transfer effect to ice skating metrics; however, improvements in certain ice skating metrics can be observed with overground training also.

Effects of Different Stretching Modalities on the Antagonist and Agonist Muscles on Isokinetic Strength and Vertical Jump Performance in Young Men.

ABSTRACT: Montalvo, S, Gonzalez, MP, Dietze-Hermosa, MS, Martinez, A, Rodriguez, S, Gomez, M, Ibarra-Mejia, G, Tan, E, and Dorgo, S. Effects of different stretching modalities on the antagonist and agonist muscles on isokinetic strength and vertical jump performance in young men. J Strength Cond Res XX(X): 000-000, 2024-Exercise warm-up may include static or dynamic stretching, impacting performance differently. This study investigated the effects of various stretching protocols on isokinetic strength, muscular activity, and vertical jump performance. Sixteen subjects, divided evenly between trained and untrained groups, underwent 8 distinct stretching conditions in random order. Outcomes measured included isokinetic knee extension and flexion torque and power, muscular activity (vastus lateralis, vastus medialis, and biceps femoris), and jump performance (jump height and modified reactive strength index [RSImod]). Responses to the stretching conditions were analyzed using a mixed-methods approach. For isokinetic knee extension, dynamic stretching of both agonist and antagonist (DY-AG-ANT) and combined dynamic agonist with static antagonist stretching (DY-AG ST-ANT) produced significant improvements. Dynamic stretching of both agonist and antagonist increased peak torque by 12.72% and average torque by 30.80%, while DY-AG ST-ANT increased peak torque by 15.61% and average torque by 41.06%. Muscular activity also improved significantly; DY-AG ST-ANT increased EMG activity of the vastus lateralis by 29.43% and vastus medialis by 70.75%. Biceps femoris saw a 33.18% increase with DY-AG and a 22.15% increase with ST-AG. Countermovement jump height improved with DY-AG-ANT (12.6%) and static antagonist (ST-ANT) conditions (11.3%) ( p < 0.05). Dynamic stretching of both agonist and antagonist also enhanced average power knee extension by 32.41%, while ST-AG DY-ANT improved it by 31.09% ( p < 0.05). Dynamic stretching, especially when combined with static stretching, optimizes isokinetic strength, muscular activity, and jump height. Coaches should incorporate dynamic stretching, alone or with static antagonist stretching, to maximize performance.

Physician Radiation Exposure During Endomyocardial Biopsy and Right Heart Catheterization.

BACKGROUND: Cardiologists performing coronary angiography (CA) and percutaneous coronary intervention (PCI) are at risk of health problems related to chronic occupational radiation exposure. Unlike during CA and PCI, physician radiation exposure during right heart catheterization (RHC) and endomyocardial biopsy (EMB) has not been adequately studied. The objective of this study was to assess physicians' radiation doses during RHC with and without EMB and compare them to those of CA and PCI. METHODS: Procedural head-level physician radiation doses were collected by real-time dosimeters. Radiation-dose metrics (fluoroscopy time, air kerma [AK] and dose area product [DAP]), and physician-level radiation doses were compared among RHC, RHC with EMB, CA, and PCI. RESULTS: Included in the study were 351 cardiac catheterization procedures. Of these, 36 (10.3%) were RHC, 42 (12%) RHC with EMB, 156 (44.4%) CA, and 117 (33.3%) PCI. RHC with EMB and CA had similar fluoroscopy time. AK and DAP were progressively higher for RHC, RHC with EMB, CA, and PCI. Head-level physician radiation doses were similar for RHC with EMB vs CA (P = 0.07). When physicians' radiation doses were normalized to DAP, RHC and RHC with EMB had the highest doses. CONCLUSION: Physicians' head-level radiation doses during RHC with EMB were similar to those of CA. After normalizing to DAP, RHC and RHC with EMB were associated with significantly higher physician radiation doses than CA or PCI. These observations suggest that additional protective measures should be undertaken to decrease physicians' radiation exposure during RHC and, in particular, RHC with EMB.

Commercial Smart Watches and Heart Rate Monitors: A Concurrent Validity Analysis.

ABSTRACT: Montalvo, S, Martinez, A, Arias, S, Lozano, A, Gonzalez, MP, Dietze-Hermosa, MS, Boyea, BL, and Dorgo, S. Smartwatches and commercial heart rate monitors: a concurrent validity analysis. J Strength Cond Res 37(9): 1802-1808, 2023-The purpose of this study was to explore the concurrent validity of 2 commercial smartwatches (Apple Watch Series 6 and 7) against a clinical criterion device (12-lead electrocardiogram [ECG]) and a field criterion device (Polar H-10) during exercise. Twenty-four male collegiate football players and 20 recreationally active young adults (10 men and 10 women) were recruited and participated in a treadmill-based exercise session. The testing protocol included 3 minutes of standing still (resting), then walking at low intensity, jogging at a moderate intensity, running at a high intensity, and postexercise recovery. The intraclass correlation (ICC 2,k ), and Bland-Altman plot analyses showed a good validity of the Apple Watch Series 6 and Series 7 with increased error (bias) as jogging and running speed increased in the football and recreational athletes. The Apple Watch Series 6 and 7 are highly valid smartwatches at rest and different exercise intensities, with validity decreasing with increased running speed. Strength and conditioning professionals and athletes can confidently use the Apple Watch Series 6 and 7 when tracking heart rate; however, caution must be taken when running at moderate or higher speeds. The Polar H-10 can surrogate a clinical ECG for practical applications.

Incremental Value of Global Longitudinal Strain to Michigan Risk Score and Pulmonary Artery Pulsatility Index in Predicting Right Ventricular Failure Following Left Ventricular Assist Devices.

BACKGROUND: The incremental utility of right ventricular (RV) strain on predicting right ventricular failure (RVF) following left ventricular assist device (LVAD) implantation, beyond clinical and haemodynamic indices, is not clear. METHODS: Two hundred and forty-six (246) patients undergoing LVAD implantation, who had transthoracic echocardiograms pre and post LVAD, pulmonary artery pulsatility index (PAPI) measurements and Michigan risk score, were included. We analysed RV global longitudinal strain (GLS) using speckle tracking echocardiography. RVF following LVAD implantation was defined as the need for medical support for >14 days, or unplanned RV assist device insertion after LVAD implantation. RESULTS: Mean preoperative RV-GLS was -7.8±2.8%. Among all, 27% developed postoperative RVF. A classification and regression tree analysis identified preoperative Michigan risk score, PAPI and RV-GLS as important parameters in predicting postoperative RVF. Eighty per cent (80%) of patients with PAPI <2.1 developed postoperative RVF, while only 4% of patients with PAPI >6.8 developed RVF. For patients with a PAPI of 2.1-3.2, having baseline Michigan risk score >2 points conferred an 81% probability of subsequent RVF. For patients with a PAPI of 3.3-6.8, having baseline RV-GLS of -4.9% or better conferred an 86% probability of no subsequent RVF. The sensitivity and specificity of this algorithm for predicting postoperative RVF were 67% and 93%, respectively, with an area under the curve of 0.87. CONCLUSION: RV-GLS has an incremental role in predicting the development of RVF post-LVAD implantation, even after controlling for clinical and haemodynamic parameters.

Changes in heart transplant waitlist and posttransplant outcomes in patients with restrictive and hypertrophic cardiomyopathy with the new heart transplant allocation system.

Historically, patients with restrictive (RCM) and hypertrophic cardiomyopathy (HCM) experienced longer wait-times for heart transplant (HT) and increased waitlist mortality. Recently, a new HT allocation system was implemented in the United States. We sought to determine the impact of the new HT system on RCM/HCM patients. Adult patients with RCM/HCM listed for HT between November 2015 and September 2019 were identified from the UNOS database. Patients were stratified into two groups: old system and new system. We identified 872 patients who met inclusion criteria. Of these, 608 and 264 were classified in the old and new system groups, respectively. The time in the waitlist was shorter (25 vs. 54 days, P < .001), with an increased frequency of HT in the new system (74% vs. 68%, P = .024). Patients who were transplanted in the new system had a longer ischemic time, increased use of temporary mechanical circulatory support and mechanical ventilation. There was no difference in posttransplant survival at 9 months (91.1% vs. 88.9%) (p = .4). We conclude that patients with RCM/HCM have benefited from the new HT allocation system, with increased access to HT without affecting short-term posttransplant survival.

Dynamic Assessment of Pulmonary Artery Pulsatility Index Provides Incremental Risk Assessment for Early Right Ventricular Failure After Left Ventricular Assist Device.

BACKGROUND: The pulmonary artery pulsatility index (PAPi) has been studied to predict right ventricular failure (RVF) after left ventricular assist device (LVAD) implantation, but only as a single time point before LVAD implantation. Multiple clinical factors and therapies impact RV function in pre-LVAD patients. Thus, we hypothesized that serial PAPi measurements during cardiac intensive care unit (CICU) optimization before LVAD implantation would provide incremental risk stratification for early RVF after LVAD implantation. METHODS AND RESULTS: Consecutive patients who underwent sequential pulmonary artery catherization with cardiac intensive care optimization before durable LVAD implantation were included. Serial hemodynamics were reviewed retrospectively across the optimization period. The optimal PAPi was defined by the initial PAPi + the PAPi at optimized hemodynamics. RVF was defined as need for a right ventricular assist device or prolonged inotrope use (>14 days postoperatively). Patients with early RVF had significantly lower mean optimal PAPi (3.5 vs 7.5, P < .001) compared with those who did not develop RVF. After adjusting for established risk factors of early RVF after LVAD implantation, the optimal PAPi was independently and incrementally associated with early RVF after LVAD implantation (odds ratio 0.64, 95% confidence interval 0.532-0.765, P < .0001). CONCLUSIONS: Optimal PAPi achieved during medical optimization before LVAD implantation provides independent and incremental risk stratification for early RVF, likely identifying dynamic RV reserve.

Extensive Tumoral Calcinosis of the Hand.

Tumoral calcinosis is a rare and benign subtype of calcinosis cutis, a group of disorders involving soft tissue calcium deposition. Only 250 cases have been described since 1898; hand involvement is exceedingly rare. We report a case of extensive calcinosis within the flexor sheath of the little finger. Presentation included a painful mass over the volar aspect of the little finger, restricted digit motion, and skin compromise at the site of the mass. Surgical debulking was performed resulting in restoration of finger function.

Influence of Corticosteroid Injections on Postoperative Infections in Carpal Tunnel Release.

PURPOSE: Corticosteroid injections (CSIs) are commonly used in carpal tunnel syndrome; however, recent literature has demonstrated risk of postoperative infection associated with preoperative CSIs in other orthopedic fields. The aim of this study was to assess the relationship of CSIs and postoperative infection following carpal tunnel release (CTR). METHODS: A single-center retrospective review was conducted from 2010 to 2019 to identify patients who underwent CTR with subsequent antibiotic prescription for chart-documented wound infection. A demographically-matched cohort of 100 patients was identified for comparison. Information on patient demographics, comorbidities, injection history, and presence of postoperative infection was collected. RESULTS: Thirty-nine patients (0.67% of all CTR patients) were identified with postoperative infections, 3 of which (0.05% of all CTR patients) were deep infections. In the infection cohort, 16 of 39 (41%) patients received an injection prior to surgery, whereas 16 of 100 (16%) patients in the control cohort received an injection. History of CSI was significantly more common in patients with postoperative infection, and patients in the infection cohort had a significantly shorter average time from injection to surgery by approximately 55 days. CONCLUSIONS: Corticosteroid injections in the preoperative period are associated with postoperative infection after CTR. Proximity of injection to time of surgery plays a role, although comorbidities, the corticosteroid dose, and frequency of injection require further study to determine risk contribution. TYPE OF STUDY/LEVEL OF EVIDENCE: Prognostic III.

Common Vertical Jump and Reactive Strength Index Measuring Devices: A Validity and Reliability Analysis.

ABSTRACT: Montalvo, S, Gonzalez, MP, Dietze-Hermosa, M, Eggleston, JD, and Dorgo, S. Common vertical jump and reactive strength index measuring devices: A validity and reliability analysis. J Strength Cond Res 35(5): 1234-1243, 2021-Several field-test devices exist to assess vertical jump, but they either lack proper validation or have been validated for the countermovement jump (CMJ) only. This study aimed to quantify the validity and reliability of metrics, including jump height and the calculated reactive strength index (RSI), obtained using the flight-time method from 4 different assessment devices with 3 different vertical jump modalities in comparison to a force platform (criterion assessment). The Optojump, Push-Band 2.0, MyJump2 mobile application, and What'sMyVert mobile application were used synchronously and together with the force platforms. Thirty subjects (17 males and 13 females; age ± SD: 23.37 ± 1.87 years) performed 5 repetitions of CMJ, squat jump (SQJ), and drop jump (DJ) with a standardized 90° knee flexion for all jumps. Relative reliability was determined by intraclass correlation (ICC) and absolute reliability by coefficient of variation (CV) analyses. Excellent reliability was considered as ICC > 0.9 and CV < 10%. Validity was obtained through an ordinary least products regression, ICC, and CV. Significance was set at p < 0.05. Reliability was excellent on jump height for the CMJ (ICC ≥ 0.98; CV ≤ 8.14%) for all instruments. With the exception of the Optojump, all instruments also had excellent reliability for the SQJ (ICC ≥ 0.98; CV ≤ 6.62) and DJ (ICC ≥ 0.94; CV ≤ 8.19). For the RSI metric, all instruments had excellent relative reliability (ICC ≥ 0.92), but none had excellent absolute reliability (CV ≥ 12.5%). The MyJump2 and What'sMyVert apps showed excellent validity on all jump modalities and RSI. The Optojump and Push-Band 2.0 devices both showed system and proportional bias for several jump modalities and RSI. Overall, both mobile applications may provide coaches with a cost-effective and reliable measurement of various vertical jumps.

Effects of Augmented Eccentric Load Bench Press Training on One Repetition Maximum Performance and Electromyographic Activity in Trained Powerlifters.

ABSTRACT: Montalvo, S, Gruber, LD, Gonzalez, MP, Dietze-Hermosa, MS, and Dorgo, S. Effects of augmented eccentric load bench press training on one repetition maximum performance and electromyographic activity in trained powerlifters. J Strength Cond Res 35(6): 1512-1519, 2021-Augmented eccentric load (AEL) training has been shown to elicit greater lower-body muscular strength increases and faster performance improvements compared with traditional strength training. However, it is unknown whether AEL training could provide similar improvements in upper-body muscular strength. Therefore, this study investigated the effects of a 4-week AEL training program on bench press one repetition maximum (1RM) strength, bar kinetics and kinematics, and surface electromyography (EMG) activity. Eight competitive powerlifters completed 5 training sessions consisting of 7 sets of a single repetition with up to 5 minutes rest between sets. Each session was completed at a predetermined AEL percentage consisting of 90% 1RM for concentric and supramaximal loads ranging from 105 to 125% 1RM during the eccentric phase with the use of eccentric hooks. After 4 weeks of AEL training, 1RM performance significantly increased from pretest to posttest (116.62 ± 27.48-124.28 ± 26.96 kg, p = 0.001). In addition, EMG amplitude of the pectoralis major decreased during the 125% AEL session to 59.86 ± 15.36% of pretest 1RM EMG values (p = 0.049, effect sizes [ESs] = 0.69). Furthermore, peak power of 1RM increased by 36.67% from pretest to posttest (p = 0.036, ES = 0.58). These study findings suggest that incorporating AEL bench press training into a 4-week training cycle may be a novel strategy to improve 1RM performance in competitive powerlifters in a short period.

The demographics and outcomes in patients with bilateral distal radius fractures.

Although distal radius fractures are quite common, bilateral distal radius fractures seldomly occur. Due to this, treatment is primarily based on surgeon experience with unilateral fractures, however bi- lateral fractures add a level of complexity : loss of functional independence. The purpose of this study was to examine a cohort of patients with bilateral distal radius fractures to identify differences in demographics, mechanism of injury, and outcomes to further our understanding of these rare injuries. 23 patients were identified retrospectively over a 5-year period that met inclusion criteria. The medical records were reviewed with multiple demographic and clinical parameters recorded and analyzed. Males were more likely to sustain high-energy mechanisms (80% vs. 53%). Patients <50 years old were more likely to sustain high-energy mechanisms (90% vs. 46%) and were more likely to be treated operatively (80% vs. 62%). The most commonly associated injury was a head injury (30%). All patients treated non-operatively reported minimal/no pain upon final follow-up where 57% of patients treated operatively noted regular pain. 75% of patients with medical comorbidities had minimal/no pain upon final follow- up. Conclusions : Patients with bilateral fractures were more likely to be younger males who suffered from higher energy mechanisms. Age was a critical factor in determining treatment strategy. Rates of associated head injuries were elevated, which is an important factor for the clinician to keep in mind when treating this population. As we further our understanding of this unique population, we can improve our treatment approaches and subsequently attain better outcomes.

Non-cardiac uptake of technetium-99m pyrophosphate in transthyretin cardiac amyloidosis.

BACKGROUND: Technetium-based bone scintigraphy is rapidly becoming the most common non-invasive imaging tool in the diagnosis of Transthyretin cardiac amyloidosis (ATTR). Skeletal muscle uptake has been described with technetium-99m-3,3-diphosphono-1,2-propanodicarboxylic acid (TcDPD), and may account for masking of bony uptake. We sought to investigate skeletal muscle uptake of technetium-99m-pyrophosphate (TcPYP) in patients with ATTR. METHODS AND RESULTS: This was a retrospective analysis of 57 patients diagnosed with ATTR who underwent TcPYP scintigraphy. Cardiac uptake was assessed on whole-body planar imaging using a semiquantitative scale (grades 0 to 3) and on single-photon emission computed tomography (SPECT) with CT attenuation correction using total myocardial counts per voxel after a 3-hour incubation. Skeletal muscle (psoas and biceps), vertebral body, LV myocardium, and blood pool mean counts were calculated. In the cohort (age 78 ± 9 years, 77% male, and 30% hereditary ATTR), there was no visualized tracer uptake in skeletal muscle or soft tissue on qualitative SPECT assessment. Total and blood pool-corrected uptake in the muscle groups were significantly less than myocardium and bone (P < 0.001). Blood pool-corrected muscle uptake was not associated with semiquantitative grade 3 vs 2 uptake (psoas P = 0.66, biceps P = 0.13) or presence of hereditary ATTR (psoas P = 0.43, biceps P = 0.69). As bony uptake decreased, there was no corresponding increase in skeletal muscle uptake. CONCLUSIONS: In patients with ATTR cardiac amyloidosis, skeletal muscle uptake of TcPYP is minimal when assessed by qualitative and quantitative metrics, and is not significantly different in patients with grade 2 vs 3 semiquantitative uptake. The properties of this tracer may be different than TcDPD with respect to non-cardiac uptake.

Targeting prostate cancer cell lines with polo-like kinase 1 inhibitors as a single agent and in combination with histone deacetylase inhibitors.

Combinations of anticancer therapies with high efficacy and low toxicities are highly sought after. Therefore, we studied the effect of polo-like kinase 1 (Plk1) inhibitors on prostate cancer cells as a single agent and in combination with histone deacetylase (HDAC) inhibitors valproic acid and vorinostat. IC50s of Plk1 inhibitors BI 2536 and BI 6727 were determined in prostate cancer cells by MTS assays. Morphological and molecular changes were assessed by immunoblotting, immunofluorescence, flow cytometry, real-time RT-PCR, and pulldown assays. Efficacy of combination therapy was assessed by MTS and clonogenic assays. IC50 values in DU145, LNCaP, and PC3 cells were 50, 75, and 175 nM, respectively, for BI 2536 and 2.5, 5, and 600 nM, respectively, for BI 6727. Human prostate fibroblasts and normal prostate epithelial cells were unaffected at these concentrations. While DU145 and LNCaP cells were solely arrested in mitosis on treatment, PC3 cells accumulated in G2 phase and mitosis, suggesting a weak spindle assembly checkpoint. Combining Plk1 inhibitors with HDAC inhibitors had synergistic antitumor effects in vitro. DMSO-treated prostate cancer cells were used as controls to study the effect of Plk1 and HDAC inhibition. Plk1 inhibitors decreased proliferation and clonogenic potential of prostate cancer cells. Hence, Plk1 may serve as an important molecular target for inhibiting prostate cancer. Combining HDAC inhibitors with BI 2536 or BI 6727 may be an effective treatment strategy against prostate cancer.

Systemic and organ-specific anti-inflammatory effects of sodium-glucose cotransporter-2 inhibitors.

Inflammation plays an essential role and is a common feature in the pathogenesis of many chronic diseases. The exact mechanisms through which sodium-glucose cotransporter-2 (SGLT2) inhibitors achieve their much-acclaimed clinical benefits largely remain unknown. In this review, we detail the systemic and tissue- or organ-specific anti-inflammatory effects of SGLT2 inhibitors using evidence from animal and human studies. We discuss the potential pathways through which SGLT2 inhibitors exert their anti-inflammatory effects, including oxidative stress, mitochondrial, and inflammasome pathways. Finally, we highlight the need for further investigation of the extent of the contribution of the anti-inflammatory effects of SGLT2 inhibition to improvements in cardiometabolic and renal outcomes in clinical studies.

Comparative kinematic analysis of high-speed treadmill vs. overground sprinting across athletic levels and sex.

BACKGROUND: This investigation aimed to dissect the kinematic differences in sprinting between high-speed treadmill and overground conditions, examining how these variations are influenced by the athlete's training status and biological sex. METHODS: A total of 40 participants, 20 NCAA Division 1 sprinters and 20 recreational runners, performed a series of maximal sprints on a high-speed treadmill and on a standardized competition overground track. Sprinting kinematic variables such as stride length, stride frequency, contact time, and flight time were collected via photoelectric sensors. Maximal sprinting kinematics were analyzed by linear mixed-effects models, considering the impacts of sprinting environment (treadmill vs. overground), training level, and sex, with leg length as fixed factors and individual athletes as random effects. Statistical significance was set at a significance level of 0.05. RESULTS: The statistical analysis revealed that high-speed treadmill sprinting significantly affects all measured kinematic variables, leading to increased stride frequency and contact time. Elite sprinters demonstrated enhanced kinematic efficiency over recreational runners, characterized by increased stride length and frequency and reduced contact time. Sex-based kinematic distinctions also emerged, with male athletes exhibiting superior stride length and frequency compared to female athletes. Leg length significantly influenced stride frequency, and an interaction effect was observed for flight time between sprint type and athletic group. CONCLUSIONS: These findings elucidate the distinct biomechanical profiles across sprinting modalities and athlete demographics, emphasizing the need for sprint training customization. This study's insights offer a valuable reference for coaches and athletes to refine training and performance assessment in varied sprinting environments.

Anticoagulation Bridging in Patients With Left Ventricular Assist Device: A Regional Analysis of HeartMate 3 Recipients.

Advances in left ventricular assist device technologies have led to an improvement in pump hemocompatibility and outcomes. Because of concerns of thromboembolic complications in prior generations of left ventricular assist devices, bridging with parenteral anticoagulants was routinely. Management strategies of subtherapeutic INRs and their effects on the current generation of devices deserve review. We performed analysis of the MOMENTUM 3 trial including 6 centers in the mid-America region. Patients with subtherapeutic INRs (INR < 2) occurring after the index admission underwent chart review to determine the management strategies taken by clinicians. Strategies were divided into two groups, bridging or nonbridging. Of the 225 patients included in the analysis, 130 (58%) patients had a total of 235 subtherapeutic international normalized ratio (INR) events. Most (n = 179, 76.2%) of these INRs were not bridged (n = 100 warfarin dose adjustment, n = 79 no change in warfarin dose). Among those INRs (n = 56, 23.8%) treated with bridging, approximately half (n = 30, 53.6%) were treated with subcutaneous agents and other half (n = 26, 46.4%) were treated with intravenous agents. There was no difference in individual outcomes or composite endpoints of death, rehospitalization, CVA, or bleeding events between the groups.