Detalhe da pesquisa
1.
Influenza A virus polymerase acidic protein E23G/K substitutions weaken key baloxavir drug-binding contacts with minimal impact on replication and transmission.
PLoS Pathog
; 18(7): e1010698, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35830486
2.
Antiviral Susceptibility of Highly Pathogenic Avian Influenza A(H5N1) Viruses Circulating Globally in 2022-2023.
J Infect Dis
; 2023 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37770028
3.
Influenza A and B viruses with reduced baloxavir susceptibility display attenuated in vitro fitness but retain ferret transmissibility.
Proc Natl Acad Sci U S A
; 117(15): 8593-8601, 2020 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32217734
4.
Baloxavir Treatment Delays Influenza B Virus Transmission in Ferrets and Results in Limited Generation of Drug-Resistant Variants.
Antimicrob Agents Chemother
; 65(11): e0113721, 2021 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34424039
5.
Multiple polymerase acidic (PA) I38X substitutions in influenza A(H1N1)pdm09 virus permit polymerase activity and cause reduced baloxavir inhibition.
J Antimicrob Chemother
; 76(4): 957-960, 2021 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33351916
6.
Synthesis, inhibitory activity and oral dosing formulation of AV5124, the structural analogue of influenza virus endonuclease inhibitor baloxavir.
J Antimicrob Chemother
; 76(4): 1010-1018, 2021 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33367751
7.
In Vitro Profiling of Laninamivir-Resistant Substitutions in N3 to N9 Avian Influenza Virus Neuraminidase Subtypes and Their Association with In Vivo Susceptibility.
J Virol
; 95(1)2020 12 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33055248
8.
Monoclonal Antibody Therapy Protects Pharmacologically Immunosuppressed Mice from Lethal Infection with Influenza B Virus.
Antimicrob Agents Chemother
; 64(9)2020 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32631823
9.
Optimizing T-705 (favipiravir) treatment of severe influenza B virus infection in the immunocompromised mouse model.
J Antimicrob Chemother
; 74(5): 1333-1341, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30715325
10.
Screening for Neuraminidase Inhibitor Resistance Markers among Avian Influenza Viruses of the N4, N5, N6, and N8 Neuraminidase Subtypes.
J Virol
; 92(1)2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29046464
11.
An I436N substitution confers resistance of influenza A(H1N1)pdm09 viruses to multiple neuraminidase inhibitors without affecting viral fitness.
J Gen Virol
; 99(3): 292-302, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29493493
12.
The PA Endonuclease Inhibitor RO-7 Protects Mice from Lethal Challenge with Influenza A or B Viruses.
Antimicrob Agents Chemother
; 61(5)2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28193653
13.
Correction for Jeong et al., "In Vitro Profiling of Laninamivir-Resistant Substitutions in N3 to N9 Avian Influenza Virus Neuraminidase Subtypes and Their Association with In Vivo Susceptibility".
J Virol
; 95(6)2021 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33627515
14.
Prevention of influenza by targeting host receptors using engineered proteins.
Proc Natl Acad Sci U S A
; 111(17): 6401-6, 2014 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-24733924
15.
The Hemagglutinin Stem-Binding Monoclonal Antibody VIS410 Controls Influenza Virus-Induced Acute Respiratory Distress Syndrome.
Antimicrob Agents Chemother
; 60(4): 2118-31, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26787699
16.
A Novel Endonuclease Inhibitor Exhibits Broad-Spectrum Anti-Influenza Virus Activity In Vitro.
Antimicrob Agents Chemother
; 60(9): 5504-14, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27381402
17.
Competitive fitness of influenza B viruses with neuraminidase inhibitor-resistant substitutions in a coinfection model of the human airway epithelium.
J Virol
; 89(8): 4575-87, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25673705
18.
Unique Determinants of Neuraminidase Inhibitor Resistance among N3, N7, and N9 Avian Influenza Viruses.
J Virol
; 89(21): 10891-900, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26292325
19.
Drug Repurposing Identifies Inhibitors of Oseltamivir-Resistant Influenza Viruses.
Angew Chem Int Ed Engl
; 55(10): 3438-41, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26833677
20.
Sialic acid-binding protein Sp2CBMTD protects mice against lethal challenge with emerging influenza A (H7N9) virus.
Antimicrob Agents Chemother
; 59(3): 1495-504, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25534734