Detalhe da pesquisa
1.
A pharmacometrics approach to assess the feasibility of capillary microsampling to replace venous sampling in clinical studies: Tafenoquine case study.
Br J Clin Pharmacol
; 89(3): 1187-1197, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36199201
2.
Identification of a Human Whole Blood-Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo.
J Pharmacol Exp Ther
; 376(3): 436-443, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33376150
3.
Population Pharmacokinetics of Tafenoquine, a Novel Antimalarial.
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30201820
4.
Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660).
Br J Clin Pharmacol
; 83(12): 2813-2820, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28800383
5.
Pharmacokinetic Interactions between Tafenoquine and Dihydroartemisinin-Piperaquine or Artemether-Lumefantrine in Healthy Adult Subjects.
Antimicrob Agents Chemother
; 60(12): 7321-7332, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27697758
6.
Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor.
Br J Clin Pharmacol
; 81(5): 971-9, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26620151
7.
Exposure-Response Analyses for Tafenoquine after Administration to Patients with Plasmodium vivax Malaria.
Antimicrob Agents Chemother
; 59(10): 6188-94, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26248362
8.
Dose-response modelling of umeclidinium and fluticasone furoate/umeclidinium in asthma.
Eur J Clin Pharmacol
; 71(9): 1051-8, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26174114
9.
Artificial Intelligence: From Buzzword to Useful Tool in Clinical Pharmacology.
Clin Pharmacol Ther
; 115(4): 698-709, 2024 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37881133
10.
Bioequivalence and the food effect of macitentan/tadalafil 10/20 fixed-dose combination tablets versus the use of single-component tablets in healthy subjects.
Pharmacol Res Perspect
; 12(3): e1202, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38764241
11.
Comment on 'The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: An individual patient data meta-analysis'.
Elife
; 132024 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38323802
12.
Exposure-response modeling of anti-depressant treatments: the confounding role of placebo effect.
J Pharmacokinet Pharmacodyn
; 40(3): 389-99, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23263774
13.
Role of Modeling and Simulation in Preclinical and Clinical Long-Acting Injectable Drug Development.
AAPS J
; 25(6): 99, 2023 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37848754
14.
Model-Based Dose Selection of Fostemsavir for Pediatric Populations With Multidrug-Resistant HIV-1 and Relative Bioavailability Assessment in Healthy Adults.
Clin Pharmacol Drug Dev
; 12(10): 991-1000, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37329260
15.
Tafenoquine co-administered with dihydroartemisinin-piperaquine for the radical cure of Plasmodium vivax malaria (INSPECTOR): a randomised, placebo-controlled, efficacy and safety study.
Lancet Infect Dis
; 23(10): 1153-1163, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37236221
16.
The American Conference on Pharmacometrics 2017 (ACoP8).
J Pharmacokinet Pharmacodyn
; 44(Suppl 1): 1-2, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28948580
17.
Tafenoquine exposure assessment, safety, and relapse prevention efficacy in children with Plasmodium vivax malaria: open-label, single-arm, non-comparative, multicentre, pharmacokinetic bridging, phase 2 trial.
Lancet Child Adolesc Health
; 6(2): 86-95, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34871570
18.
Effect of body mass index on pharmacokinetics of paclitaxel in patients with early breast cancer.
Cancer Med
; 10(9): 3068-3076, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33826243
19.
Model-Informed Approach to Assess the Treatment Effect Conditional to the Level of Placebo Response.
Clin Pharmacol Ther
; 106(6): 1253-1260, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31397904
20.
Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects.
Am J Cardiovasc Drugs
; 19(3): 335-342, 2019 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-30637626