Detalhe da pesquisa
1.
A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology.
Bioconjug Chem
; 24(7): 1256-63, 2013 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-23808985
2.
Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates.
J Antimicrob Chemother
; 67(7): 1683-96, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22547662
3.
DNA interstrand cross-linking and in vivo antitumor activity of the extended pyrrolo[2,1-c][1,4]benzodiazepine dimer SG2057.
Invest New Drugs
; 30(3): 950-8, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21384134
4.
Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody-Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer.
Mol Cancer Ther
; 21(9): 1439-1448, 2022 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35793464
5.
Synthesis of a novel C2/C2'-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate.
Bioorg Med Chem Lett
; 19(22): 6463-6, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19811912
6.
Synthesis and evaluation of pyrrolobenzodiazepine dimer antibody-drug conjugates with dual ß-glucuronide and dipeptide triggers.
Eur J Med Chem
; 179: 591-607, 2019 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31279293
7.
SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads.
Clin Cancer Res
; 24(24): 6570-6582, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30131388
8.
Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers.
J Med Chem
; 60(23): 9490-9507, 2017 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29112410
9.
Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers.
Mol Cancer Ther
; 16(5): 871-878, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28223423
10.
SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations.
Cancer Res
; 64(18): 6700-6, 2004 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15374987
11.
SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.
Cancer Res
; 64(18): 6693-9, 2004 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15374986
12.
Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
J Med Chem
; 47(5): 1161-74, 2004 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-14971896
13.
SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer prodrug that cross-links DNA and exerts highly potent antitumor activity.
Cancer Res
; 70(17): 6849-58, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20660714
14.
Synthesis of the first examples of A-C8/C-C2 amide-Linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.
Bioorg Med Chem Lett
; 13(14): 2277-80, 2003 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12824017
15.
A novel approach to the synthesis of cytotoxic C2-C3 unsaturated pyrrolo[2,1-c]benzodiazepines (PBDs) with conjugated acrylyl C2-substituents.
Bioorg Med Chem Lett
; 14(6): 1547-9, 2004 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-15006400