Detalhe da pesquisa
1.
LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions.
J Biol Chem
; 287(26): 22184-95, 2012 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22514275
2.
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones.
Bioorg Med Chem Lett
; 22(11): 3699-703, 2012 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22560470
3.
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: aminoalkoxypyrimidine carboxamides.
Bioorg Med Chem Lett
; 22(11): 3693-8, 2012 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22560473
4.
Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.
Bioorg Med Chem Lett
; 20(9): 2828-31, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20356737
5.
Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships.
J Med Chem
; 51(17): 5243-63, 2008 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18690678
6.
Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds.
Antimicrob Agents Chemother
; 51(2): 657-66, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17116675
7.
Nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator, an ABC transporter, catalyze adenylate kinase activity but not ATP hydrolysis.
J Biol Chem
; 281(7): 4058-68, 2006 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-16361259
8.
In vitro characterization of the antibacterial spectrum of novel bacterial type II topoisomerase inhibitors of the aminobenzimidazole class.
Antimicrob Agents Chemother
; 50(4): 1228-37, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16569833
9.
Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase.
Antimicrob Agents Chemother
; 48(5): 1856-64, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15105144
10.
Active-site residues of Escherichia coli DNA gyrase required in coupling ATP hydrolysis to DNA supercoiling and amino acid substitutions leading to novobiocin resistance.
Antimicrob Agents Chemother
; 47(3): 1037-46, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12604539