Pesquisa | BVS IEC

1.

Flattening the curve-How to get better results with small deep-mutational-scanning datasets.

Wirnsberger, Gregor; Pritisanac, Iva; Oberdorfer, Gustav; Gruber, Karl.

Proteins ; 92(7): 886-902, 2024 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-38501649

2.

Ligand-Directed Chemistry on Glycoside Hydrolases - A Proof of Concept Study.

Prasch, Herwig; Wolfsgruber, Andreas; Thonhofer, Martin; Culum, André; Mandl, Christoph; Weber, Patrick; Zündel, Melanie; Nasseri, Seyed A; Gonzalez Santana, Andres; Tegl, Gregor; Nidetzky, Bernd; Gruber, Karl; Stütz, Arnold E; Withers, Stephen G; Wrodnigg, Tanja M.

Chembiochem ; 24(23): e202300480, 2023 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-37715738

3.

Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes.

Grabner, Gernot F; Guttenberger, Nikolaus; Mayer, Nicole; Migglautsch-Sulzer, Anna K; Lembacher-Fadum, Christian; Fawzy, Nermeen; Bulfon, Dominik; Hofer, Peter; Züllig, Thomas; Hartig, Lennart; Kulminskaya, Natalia; Chalhoub, Gabriel; Schratter, Margarita; Radner, Franz P W; Preiss-Landl, Karina; Masser, Sarah; Lass, Achim; Zechner, Rudolf; Gruber, Karl; Oberer, Monika; Breinbauer, Rolf; Zimmermann, Robert.

J Am Chem Soc ; 144(14): 6237-6250, 2022 04 13.

Artigo em Inglês | MEDLINE | ID: mdl-35362954

4.

Structure-Based Demystification of Radical Catalysis by a Coenzyme B₁₂ Dependent Enzyme-Crystallographic Study of Glutamate Mutase with Cofactor Homologues.

Gruber, Karl; Csitkovits, Vanessa; Lyskowski, Andrzej; Kratky, Christoph; Kräutler, Bernhard.

Angew Chem Int Ed Engl ; 61(35): e202208295, 2022 08 26.

Artigo em Inglês | MEDLINE | ID: mdl-35793207

5.

Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice.

Jha, Shalinee; Taschler, Ulrike; Domenig, Oliver; Poglitsch, Marko; Bourgeois, Benjamin; Pollheimer, Marion; Pusch, Lisa M; Malovan, Grazia; Frank, Sasa; Madl, Tobias; Gruber, Karl; Zimmermann, Robert; Macheroux, Peter.

J Biol Chem ; 295(40): 13711-13723, 2020 10 02.

Artigo em Inglês | MEDLINE | ID: mdl-32546481

6.

Diversification of the mygalomorph spider genus Aname (Araneae: Anamidae) across the Australian arid zone: Tracing the evolution and biogeography of a continent-wide radiation.

Rix, Michael G; Wilson, Jeremy D; Huey, Joel A; Hillyer, Mia J; Gruber, Karl; Harvey, Mark S.

Mol Phylogenet Evol ; 160: 107127, 2021 07.

Artigo em Inglês | MEDLINE | ID: mdl-33667632

7.

Efficient Entropy-Driven Inhibition of Dipeptidyl Peptidase III by Hydroxyethylene Transition-State Peptidomimetics.

Ivkovic, Jakov; Jha, Shalinee; Lembacher-Fadum, Christian; Puschnig, Johannes; Kumar, Prashant; Reithofer, Viktoria; Gruber, Karl; Macheroux, Peter; Breinbauer, Rolf.

Chemistry ; 27(56): 14108-14120, 2021 Oct 07.

Artigo em Inglês | MEDLINE | ID: mdl-34314529

8.

The catalytic machinery of the FAD-dependent AtBBE-like protein 15 for alcohol oxidation: Y193 and Y479 form a catalytic base, Q438 and R292 an alkoxide binding site.

Messenlehner, Julia; Hetman, Michael; Tripp, Adrian; Wallner, Silvia; Macheroux, Peter; Gruber, Karl; Daniel, Bastian.

Arch Biochem Biophys ; 700: 108766, 2021 03 30.

Artigo em Inglês | MEDLINE | ID: mdl-33485849

9.

Cities as evolutionary experiments: As cities and other man-made environments encroach on natural settings, species evolve to cope.

Gruber, Karl F.

EMBO Rep ; 20(11): e49401, 2019 11 05.

Artigo em Inglês | MEDLINE | ID: mdl-31657127

10.

A Fungal Ascorbate Oxidase with Unexpected Laccase Activity.

Braunschmid, Verena; Fuerst, Sarah; Perz, Veronika; Zitzenbacher, Sabine; Hoyo, Javier; Fernandez-Sanchez, Cesar; Tzanov, Tzanko; Steinkellner, Georg; Gruber, Karl; Nyanhongo, Gibson S; Ribitsch, Doris; Guebitz, Georg M.

Int J Mol Sci ; 21(16)2020 Aug 11.

Artigo em Inglês | MEDLINE | ID: mdl-32796622

11.

Oxidative cyclization of N-methyl-dopa by a fungal flavoenzyme of the amine oxidase family.

Lahham, Majd; Pavkov-Keller, Tea; Fuchs, Michael; Niederhauser, Johannes; Chalhoub, Gabriel; Daniel, Bastian; Kroutil, Wolfgang; Gruber, Karl; Macheroux, Peter.

J Biol Chem ; 293(44): 17021-17032, 2018 11 02.

Artigo em Inglês | MEDLINE | ID: mdl-30194285

12.

Structure and Catalytic Mechanism of a Bacterial Friedel-Crafts Acylase.

Pavkov-Keller, Tea; Schmidt, Nina G; Zadlo-Dobrowolska, Anna; Kroutil, Wolfgang; Gruber, Karl.

Chembiochem ; 20(1): 88-95, 2019 01 02.

Artigo em Inglês | MEDLINE | ID: mdl-30318713

13.

Cleaning up pollutants to protect future health.

Gruber, Karl.

Nature ; 555(7695): S20-S22, 2018 03 08.

Artigo em Inglês | MEDLINE | ID: mdl-29517021

14.

Cleaning up pollutants to protect future health.

Gruber, Karl.

Nature ; 555(7695): S20-S22, 2018 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-32094973

15.

Evolving the Promiscuity of Elizabethkingia meningoseptica Oleate Hydratase for the Regio- and Stereoselective Hydration of Oleic Acid Derivatives.

Engleder, Matthias; Strohmeier, Gernot A; Weber, Hansjörg; Steinkellner, Georg; Leitner, Erich; Müller, Monika; Mink, Daniel; Schürmann, Martin; Gruber, Karl; Pichler, Harald.

Angew Chem Int Ed Engl ; 58(22): 7480-7484, 2019 05 27.

Artigo em Inglês | MEDLINE | ID: mdl-30848865

16.

Zinc Substitution of Cobalt in VitaminâB₁₂ : Zincobyric acid and Zincobalamin as Luminescent Structural B₁₂ -Mimics.

Kieninger, Christoph; Baker, Joseph A; Podewitz, Maren; Wurst, Klaus; Jockusch, Steffen; Lawrence, Andrew D; Deery, Evelyne; Gruber, Karl; Liedl, Klaus R; Warren, Martin J; Kräutler, Bernhard.

Angew Chem Int Ed Engl ; 58(41): 14568-14572, 2019 10 07.

Artigo em Inglês | MEDLINE | ID: mdl-31420932

17.

Chemoenzymatic Total Synthesis of Deoxy-, epi-, and Podophyllotoxin and a Biocatalytic Kinetic Resolution of Dibenzylbutyrolactones.

Lazzarotto, Mattia; Hammerer, Lucas; Hetmann, Michael; Borg, Annika; Schmermund, Luca; Steiner, Lorenz; Hartmann, Peter; Belaj, Ferdinand; Kroutil, Wolfgang; Gruber, Karl; Fuchs, Michael.

Angew Chem Int Ed Engl ; 58(24): 8226-8230, 2019 06 11.

Artigo em Inglês | MEDLINE | ID: mdl-30920120

18.

The Hydrogenobyric Acid Structure Reveals the Corrin Ligand as an Entatic State Module Empowering B₁₂ Cofactors for Catalysis.

Kieninger, Christoph; Deery, Evelyne; Lawrence, Andrew D; Podewitz, Maren; Wurst, Klaus; Nemoto-Smith, Emi; Widner, Florian J; Baker, Joseph A; Jockusch, Steffen; Kreutz, Christoph R; Liedl, Klaus R; Gruber, Karl; Warren, Martin J; Kräutler, Bernhard.

Angew Chem Int Ed Engl ; 58(31): 10756-10760, 2019 07 29.

Artigo em Inglês | MEDLINE | ID: mdl-31115943

19.

Agrobiodiversity: The living library.

Gruber, Karl.

Nature ; 544(7651): S8-S10, 2017 04 26.

Artigo em Inglês | MEDLINE | ID: mdl-28445449

20.

Clinical devices and services: Repair shops.

Drew, Liam; Scott, Andrew; Morgan, Branwen; Gruber, Karl.

Nature ; 545(7654): S21-S24, 2017 05 17.

Artigo em Inglês | MEDLINE | ID: mdl-28514414

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Instituto Evandro Chagas

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Flattening the curve-How to get better results with small deep-mutational-scanning datasets.

Ligand-Directed Chemistry on Glycoside Hydrolases - A Proof of Concept Study.

Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes.

Structure-Based Demystification of Radical Catalysis by a Coenzyme B₁₂ Dependent Enzyme-Crystallographic Study of Glutamate Mutase with Cofactor Homologues.

Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice.

Diversification of the mygalomorph spider genus Aname (Araneae: Anamidae) across the Australian arid zone: Tracing the evolution and biogeography of a continent-wide radiation.

Efficient Entropy-Driven Inhibition of Dipeptidyl Peptidase III by Hydroxyethylene Transition-State Peptidomimetics.

The catalytic machinery of the FAD-dependent AtBBE-like protein 15 for alcohol oxidation: Y193 and Y479 form a catalytic base, Q438 and R292 an alkoxide binding site.

Cities as evolutionary experiments: As cities and other man-made environments encroach on natural settings, species evolve to cope.

A Fungal Ascorbate Oxidase with Unexpected Laccase Activity.

Oxidative cyclization of N-methyl-dopa by a fungal flavoenzyme of the amine oxidase family.

Structure and Catalytic Mechanism of a Bacterial Friedel-Crafts Acylase.

Cleaning up pollutants to protect future health.

Cleaning up pollutants to protect future health.

Evolving the Promiscuity of Elizabethkingia meningoseptica Oleate Hydratase for the Regio- and Stereoselective Hydration of Oleic Acid Derivatives.

Zinc Substitution of Cobalt in VitaminâB₁₂ : Zincobyric acid and Zincobalamin as Luminescent Structural B₁₂ -Mimics.

Chemoenzymatic Total Synthesis of Deoxy-, epi-, and Podophyllotoxin and a Biocatalytic Kinetic Resolution of Dibenzylbutyrolactones.

The Hydrogenobyric Acid Structure Reveals the Corrin Ligand as an Entatic State Module Empowering B₁₂ Cofactors for Catalysis.

Agrobiodiversity: The living library.

Clinical devices and services: Repair shops.