RESUMO
The miR-92a family, including miR-25, miR-92a-1, miR-92a-2 and miR-363, arises from three different paralog clusters miR-17-92, miR-106a-363, and miR-106b-25 that are highly conservative in the process of evolution, and it was thought as a group of microRNAs (miRNAs) correlated with endothelial cells. Aberrant expression of miR-92a family was detected in multiple cancers, and the disturbance of miR-92a family was related with tumorigenesis and tumor development. In this review, the progress on the relationship between miR-92a family and their target genes and malignant tumors will be summarized.
Assuntos
Transformação Celular Neoplásica/genética , MicroRNAs/genética , Invasividade Neoplásica/genética , Metástase Neoplásica/genética , Neoplasias/genética , Apoptose/genética , Células Endoteliais/citologia , Regulação Neoplásica da Expressão Gênica , HumanosRESUMO
Retinoic acid (RA) is an active derivative of vitamin A, and it has different isomers, including ATRA (all-trans-retinoic acid), 13-cRA (13-cis-retinoic acid) and 9-cRA (9-cis-retinoic acid), etc. Combining with RARs and RXRs, RA plays important roles not only in embryonic development but also in cellular growth and differentiation through transcriptional regulation of its target genes. Following the successful application in the differentiation therapy of acute promyelocytic leukemia (APL) in clinical, recent studies have found that the disturbance of RA signal transduction was also related to differentiation, proliferation or apoptosis of tumor cells. To develop novel mechanisms-based differentiation therapy for other tumors, the relationship between RA or its receptors and tumors will be summarized in this review.