Artificial intelligence-supported applications in head and neck cancer radiotherapy treatment planning and dose optimisation.

INTRODUCTION: The aim of this review is to describe how various AI-supported applications are used in head and neck cancer radiotherapy treatment planning, and the impact on dose management in regards to target volume and nearby organs at risk (OARs). METHODS: Literature searches were conducted in databases and publisher portals Pubmed, Science Direct, CINAHL, Ovid, and ProQuest to peer reviewed studies published between 2015 and 2021. RESULTS: Out of 464 potential ones, ten articles covering the topic were selected. The benefit of using deep learning-based methods to automatically segment OARs is that it makes the process more efficient producing clinically acceptable OAR doses. In some cases automated treatment planning systems can outperform traditional systems in dose prediction. CONCLUSIONS: Based on the selected articles, in general AI-based systems produced time savings. Also, AI-based solutions perform at the same level or better than traditional planning systems considering auto-segmentation, treatment planning and dose prediction. However, their clinical implementation into routine standard of care should be carefully validated IMPLICATIONS TO PRACTICE: AI has a primary benefit in reducing treatment planning time and improving plan quality allowing dose reduction to the OARs thereby enhancing patients' quality of life. It has a secondary benefit of reducing radiation therapists' time spent annotating thereby saving their time for e.g. patient encounters.

Towards a Switchable AR/VR Near-eye Display with Accommodation-Vergence and Eyeglass Prescription Support.

In this paper, we present our novel design for switchable AR/VR near-eye displays which can help solve the vergence-accommodation-conflict issue. The principal idea is to time-multiplex virtual imagery and real-world imagery and use a tunable lens to adjust focus for the virtual display and the see-through scene separately. With this novel design, prescription eyeglasses for near- and far-sighted users become unnecessary. This is achieved by integrating the wearer's corrective optical prescription into the tunable lens for both virtual display and see-through environment. We built a prototype based on the design, comprised of micro-display, optical systems, a tunable lens, and active shutters. The experimental results confirm that the proposed near-eye display design can switch between AR and VR and can provide correct accommodation for both.