Detalhe da pesquisa
1.
Preclinical characterization of ISB 1342, a CD38 × CD3 T-cell engager for relapsed/refractory multiple myeloma.
Blood
; 142(3): 260-273, 2023 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37192303
2.
Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[d]imidazole series - Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2.
Bioorg Med Chem Lett
; 28(7): 1211-1218, 2018 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29519738
3.
Discovery of 5-(2-chloro-4'-(1H-imidazol-1-yl)-[1,1'-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD.
Bioorg Med Chem Lett
; 28(23-24): 3766-3773, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30340896
4.
Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1.
Bioorg Med Chem Lett
; 27(23): 5131-5138, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29100801
5.
Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model.
Bioorg Med Chem Lett
; 27(11): 2594-2601, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28400234
6.
Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2',3':3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor.
Bioorg Med Chem Lett
; 26(24): 5977-5984, 2016 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27865703
7.
Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: Part I.
Bioorg Med Chem Lett
; 24(9): 2073-8, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24725435
8.
Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: part II.
Bioorg Med Chem Lett
; 24(15): 3238-42, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24980052
9.
Discovery of benzo[d]imidazo[5,1-b]thiazole as a new class of phosphodiesterase 10A inhibitors.
Bioorg Med Chem Lett
; 23(24): 6747-54, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24231362
10.
Synthesis and pharmacological evaluation of novel N-aryl-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamides as TRPM8 antagonists.
Bioorg Med Chem
; 21(21): 6542-53, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24055075
11.
Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation.
Bioorg Med Chem Lett
; 22(9): 3223-8, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22487174
12.
Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson's disease model.
Bioorg Med Chem Lett
; 22(19): 6286-91, 2012 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22944118
13.
Single-step Protein A and Protein G avidity purification methods to support bispecific antibody discovery and development.
MAbs
; 11(8): 1464-1478, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31462177
14.
Design, Synthesis, and Pharmacological Evaluation of 5,6-Disubstituted Pyridin-2(1H)-one Derivatives as Phosphodiesterase 10A (PDE10A) Antagonists.
J Med Chem
; 58(20): 8292-308, 2015 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26421921
15.
Utility of a column-switching LC/MS/MS method in cytochrome P450 inhibition assays using human liver microsomes.
Drug Metabol Drug Interact
; 28(3): 177-85, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23729559