Detalhe da pesquisa
1.
Effective "activated PI3Kδ syndrome"-targeted therapy with the PI3Kδ inhibitor leniolisib.
Blood
; 130(21): 2307-2316, 2017 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28972011
2.
Oxysterols direct immune cell migration via EBI2.
Nature
; 475(7357): 524-7, 2011 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21796212
3.
Second generation S1P pathway modulators: research strategies and clinical developments.
Biochim Biophys Acta
; 1841(5): 745-58, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24239768
4.
Small molecule induced STING degradation facilitated by the HECT ligase HERC4.
Nat Commun
; 15(1): 4584, 2024 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38811577
5.
STING Agonists/Antagonists: Their Potential as Therapeutics and Future Developments.
Cells
; 11(7)2022 03 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35406723
6.
Requirement for O-linked N-acetylglucosaminyltransferase in lymphocytes activation.
EMBO J
; 26(20): 4368-79, 2007 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-17882263
7.
Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors.
Nat Chem Biol
; 5(6): 428-34, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19430484
8.
TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis.
Cell Rep
; 37(6): 109977, 2021 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34758308
9.
STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia.
iScience
; 24(12): 103434, 2021 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34877494
10.
The O-linked N-acetylglucosamine modification in cellular signalling and the immune system. 'Protein modifications: beyond the usual suspects' review series.
EMBO Rep
; 9(8): 748-53, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18617890
11.
Pyrazole derived from (+)-3-carene; a novel potent, selective scaffold for sphingosine-1-phosphate (S1P(1)) receptor agonists.
Bioorg Med Chem Lett
; 20(1): 35-7, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19954976
12.
Proton-sensing G-protein-coupled receptors.
Nature
; 425(6953): 93-8, 2003 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-12955148
13.
Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors.
ACS Med Chem Lett
; 10(6): 887-892, 2019 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31223443
14.
Reversible translocation of p115-RhoGEF by G(12/13)-coupled receptors.
J Cell Biochem
; 104(5): 1660-70, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18320579
15.
Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo.
J Med Chem
; 61(3): 865-880, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29359565
16.
A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model.
Chem Biol
; 13(11): 1227-34, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17114004
17.
Identification of SPPL2a Inhibitors by Multiparametric Analysis of a High-Content Ultra-High-Throughput Screen.
SLAS Discov
; 22(9): 1106-1119, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28731783
18.
Exporting calcium from cells.
Cell Calcium
; 38(3-4): 281-9, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16102821
19.
Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer.
J Med Chem
; 48(16): 5373-7, 2005 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-16078855
20.
Differential membrane targeting of the SERCA and PMCA calcium pumps: experiments with recombinant chimeras.
FASEB J
; 16(6): 519-28, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11919154