[Apparent internal male pseudo-hermaphroditism. Gynecomastia. Negative gonad surgical research. Caryotype 46, XX. Presence of H-Y antigen (author's transl)]. / Pseudo-hermaphrodisme mâle interne apparent. Gynécomastie. Recherche chirurgicale des gonades négatives. Caryotype 46, XX. Présence d'antigène H-Y.

Boy 15. Aspect of delayed puberty with empty scrotum and gynecomastia. Caryotype 46, XX. Presence of H.Y. Antigen. Plasmatic testosterone 1 020 pg/ml. Normal plasmatic FSH and LH. Hypotrophic uterus and tubes. No gonad found. Small right epididymis. Complete virilization by testosterone.

[46 XX karyotype men (author's transl)]. / Les hommes à caryotype 46, XX.

85 cases of this syndrom have been published since the original case in 1964. The main clinical symptoms are those of Klinefelter's disease from which it differs by the caryotype only. Azoospermie is the rule. 3 mechanisms can be implicated: Mosaic 46 XX/47 XY with secondary loss of Y chromosome; Translocation of a part of Y chromosome upon an autosome or Y chromosome; Autosomal mutant gene acting upon the masculinizing site of X chromosome and inducing the primitive development of the testis as the short arm and proximal part of the long arm of Y chromosome normally do. These mechanisms perhaps are distinct origins of a syndrom which clinic alone cannot dissociate.

[Incomplete testicular feminisation syndrome by testosterone insensitivity (author's transl)]. / Pseudo-hermaphrodisme mâle incomplet par insensibilité à la testostérone

Male pseudo-hermaphroditism by partial testosterone sensitivity, without steroido-genesis abnormality, without apparent 5 alpha reductase deficit - Empty complete scrotum and hypospadias surgically normalized. At 39, scrotal testis 32 X 15 mm right, 23 X 10 mm left. Infantile penis and prostata. Gynoid scapulo-pelvic proportions, adipo-muscular ratio and fat distribution. Bilateral gynecomastia. Caryotype 46 XY - 17 ks 26 mg. After intravenous 100 ng LH RH: plasma (pl) LH increased 105 to 285 ng/ml, pl testosterone 5 ng/ml unchanged, pl oestradiol 115 to 135 pg/ml. 48 h after intra muscular 300 mg testosterone propionate: pl testosterone increased, 13 to 39 ng/ml, androstenedione 1,5 to 3,04 ng/ml, dihydrotestosterone 0,85 to 1,45 ng/ml, OEstradiol 52 to 110 pg/ml. No effect of 29 g testosterone oenanthate in 2 years.

[Salmonella bredney: a rare cause of mycotic aneurysm]. / Salmonella bredney: une cause rare d'anévrisme mycotique.

Mycotic aneurysms are rare, remain asymptomatic for a long time, and may be life threatening by their rupture if therapy is delayed. Historically associated with Streptococcus pyogenes and Staphylococcus aureus, they now frequently involve Salmonella species in elderly or immunodeficient patients, and complicate vascular investigation or surgical procedures. Frequently located in the abdominal aorta, they can also be found rarely in other location. Therapy associates antibiotics and surgical debridement with reestablishment of vascular continuity. We report a case of ruptured popliteal aneurysm with Salmonella bredney bacteraemia.

[Male pseudohermaphroditism. Etiologic diagnosis. 2]. / Les pseudo-hermaphrodismes mâles. Conduite de leur diagnostic étiologique. Eeuxième partie.

The cause of male pseudohermaphroditism : polydystrophy, gonadal dysplasia, agenesis or precocious abiotrophy of Leydig cells, defect of testicular stimulation by foetal hypophysis, testosterone, biosynthesis abnormalities 5 varieties of which are identified, 5 alpha reductase defect, testosterone or dihydrotestosterone insenstivity complete and incomplete forms, defect of secretion or action of Mullerian ducts inhibitor can be found in the majority of cases by clinical and para-clinical analysis. Practical management results from this diagnosis.

[Insulinomas in children. Histologic and ultrastructural study. (apropos of 2 cases)]. / Les insulinomes de l'enfant. Etude histologique et ultrastructurale (A propos de deux cas)

The authors report two case-histories of insulin-secreting tumors of the pancreas in children. They emphasize the rare occurence and the percularity of these tumors with regard to insulinomas in adults. The ultrastructural and histopathological examination showed: --the presence of a "junction area" rich in centro-acinar cells between the pancreas and the tumor, --within the tumor, the existence of exocrine elements i.e. acinar cells and more or less differentiated canalar structures. On behalf of these findings the authors discuss the problem of the histogenesis of these tumors. Is it a matter of endocrine adenomatous hyperplasia of centro-acinar origin, or of real "apudoma"?

[Multiple hepatic cysts in rat rendered diabetic by streptozotocin and treated by islets of Langerhans grafts: the role of streptozotocin]. / Polykystose hépatique chez le rat rendu diabétique par la streptozotocine et traité par greffe d'îlots de Langerhans: rôle de la streptozotocine.

This study is based on the investigation by light and electron microscopy of hepatic biopsies from 14 rats rendered diabetic by streptozotocin and treated by portal embolization of islets of Langerhans. Macroscopically, voluminous projecting cysts were observed, sometimes occupying a whole lobe. By light microscopy, the cysts were lined with canalicular-type epithelium. Ultrastructural studies confirmed the canalicular nature of these cells and cilia were frequently observed. The presence of identical cysts in rats rendered diabetic by streptozotocin but not treated by embolization proves that this product is the agent responsible for the induction of this adenomatosis.