Detalhe da pesquisa
1.
How autoreactive thymocytes differentiate into regulatory versus effector CD4+ T cells after avoiding clonal deletion.
Nat Immunol
; 24(4): 637-651, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36959291
2.
Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus.
Nat Immunol
; 23(5): 731-742, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35523960
3.
Identification of lineage-specifying cytokines that signal all CD8+-cytotoxic-lineage-fate 'decisions' in the thymus.
Nat Immunol
; 18(11): 1218-1227, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28945245
4.
Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors.
Nat Immunol
; 17(12): 1415-1423, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27668801
5.
Lck availability during thymic selection determines the recognition specificity of the T cell repertoire.
Cell
; 154(6): 1326-41, 2013 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24034254
6.
Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function.
Nat Immunol
; 16(5): 517-24, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25848867
7.
IL-7 signaling must be intermittent, not continuous, during CD8⺠T cell homeostasis to promote cell survival instead of cell death.
Nat Immunol
; 14(2): 143-51, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23242416
8.
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.
Nat Immunol
; 11(3): 257-64, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20118929
9.
Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals.
Immunity
; 38(6): 1116-28, 2013 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23746651
10.
αß T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities.
Immunity
; 36(1): 79-91, 2012 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22209676
11.
Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.
Immunity
; 31(3): 480-90, 2009 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-19747858
12.
Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.
Blood
; 119(22): 5155-63, 2012 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-22403258
13.
Pillars Article: Coreceptor Reversal in the Thymus: Signaled CD4+8+ Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8+ T Cells. Immunity. 2000. 13: 59-71.
J Immunol
; 196(5): 1985-97, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26896482
14.
Defined alphabeta T cell receptors with distinct ligand specificities do not require those ligands to signal double negative thymocyte differentiation.
J Exp Med
; 199(12): 1719-24, 2004 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15210747
15.
Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells.
J Exp Med
; 197(12): 1709-19, 2003 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-12810689
16.
Novel MHC-Independent αßTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus.
Front Immunol
; 11: 1216, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32612609
17.
E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex.
J Exp Med
; 216(8): 1749-1761, 2019 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31201207
18.
The general transcription factor TAF7 is essential for embryonic development but not essential for the survival or differentiation of mature T cells.
Mol Cell Biol
; 32(10): 1984-97, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22411629
19.
Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.
Immunity
; 27(5): 735-50, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18023370
20.
Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model.
J Immunol
; 177(10): 6613-25, 2006 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17082573