Detalhe da pesquisa
1.
Characterization and preclinical evaluation of a protease activated receptor 2 (PAR2) monoclonal antibody as a preventive therapy for migraine.
Cephalalgia
; 40(14): 1535-1550, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33131305
2.
Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo.
Neurobiol Dis
; 132: 104582, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31445162
3.
Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice.
Cell Rep Med
; 4(3): 100957, 2023 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36889319
4.
Case studies addressing human pharmacokinetic uncertainty using a combination of pharmacokinetic simulation and alternative first in human paradigms.
Xenobiotica
; 42(1): 57-74, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21992032
5.
Application of PBPK modelling in drug discovery and development at Pfizer.
Xenobiotica
; 42(1): 94-106, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22035569
6.
Antibody-oligonucleotide conjugate achieves CNS delivery in animal models for spinal muscular atrophy.
JCI Insight
; 7(24)2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36346674
7.
Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons.
Nat Commun
; 11(1): 3258, 2020 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32591533
8.
A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model.
J Cereb Blood Flow Metab
; 39(10): 2074-2088, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29845881
9.
N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors.
Bioorg Med Chem Lett
; 18(15): 4308-11, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18625557
10.
Isolation of blood-brain barrier-crossing antibodies from a phage display library by competitive elution and their ability to penetrate the central nervous system.
MAbs
; 10(2): 304-314, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29182455
11.
Toward ß-Secretase-1 Inhibitors with Improved Isoform Selectivity.
J Med Chem
; 61(8): 3491-3502, 2018 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29617572
12.
Enhanced delivery of IL-1 receptor antagonist to the central nervous system as a novel anti-transferrin receptor-IL-1RA fusion reverses neuropathic mechanical hypersensitivity.
Pain
; 158(4): 660-668, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28009628
13.
Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7.
J Med Chem
; 60(16): 7029-7042, 2017 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28682065
14.
Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels.
Clin Pharmacokinet
; 55(7): 875-887, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26895021