Detalhe da pesquisa
1.
Synaptotagmin Binding to Botulinum Neurotoxins.
Biochemistry
; 59(4): 491-498, 2020 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31809018
2.
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Nature
; 508(7495): 215-21, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24695224
3.
MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.
Nucleic Acids Res
; 46(20): 10888-10904, 2018 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30304478
4.
Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
Biochemistry
; 57(5): 593-603, 2018 02 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29281266
5.
Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Nature
; 544(7651): 508, 2017 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28447629
6.
Glycans Confer Specificity to the Recognition of Ganglioside Receptors by Botulinum Neurotoxin A.
J Am Chem Soc
; 139(1): 218-230, 2017 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27958736
7.
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nat Cancer
; 3(2): 156-172, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35228749
8.
Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring-An Inactive Enzyme with Intact Substrate Binding.
Biomolecules
; 10(12)2020 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33287293
9.
Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding.
Toxins (Basel)
; 10(4)2018 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29649119
10.
Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX-type gene cluster.
FEBS Lett
; 591(22): 3781-3792, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29067689
11.
Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space.
J Med Chem
; 60(19): 8160-8169, 2017 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28929756
12.
Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor.
Cancer Res
; 77(4): 937-948, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27899380
13.
Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition.
Cancer Res
; 76(8): 2366-75, 2016 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26862114
14.
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.
Nat Commun
; 6: 7871, 2015 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26238318