RESUMO
Brain metastases in breast cancer develop for 24-32 months after the detection of the primary tumor. The study included patients with brain metastases who were divided into three groups: the first group--with early chemoradiotherapy (CRT) without induction chemotherapy (IC) by capecitabine; the second group--with delayed CRT with 4 or 8 courses of IC by capecitabine; the third group (a historical control) who received only whole brain radiation therapy. The median time to progression of intracranial metastases was 15.3, 12 and 5 months, respectively. The median time to the intracranial progression significantly less in the third group (5 months) compared with the first (15.3 months) (p = 0.0007) and the second (12 months) (p = 0.027) groups. The overall survival rate was 22.1, 15.1 and 6.8 months in three groups, respectively.
Assuntos
Antineoplásicos/administração & dosagem , Neoplasias Encefálicas/terapia , Neoplasias da Mama/terapia , Capecitabina/administração & dosagem , Quimiorradioterapia Adjuvante , Irradiação Craniana , Adulto , Idoso , Neoplasias Encefálicas/mortalidade , Neoplasias Encefálicas/secundário , Neoplasias da Mama/mortalidade , Neoplasias da Mama/patologia , Terapia Combinada , Intervalo Livre de Doença , Feminino , Humanos , Pessoa de Meia-Idade , Federação Russa/epidemiologia , Análise de Sobrevida , Fatores de Tempo , Resultado do TratamentoRESUMO
Morbidity and mortality from pancreatic cancer is steadily increasing. Resectable cases are not more than 20%. Conventional schemes of chemoradiation and radiation therapy are durable over the time, have toxicity and low treatment outcomes. Many foreign authors consider as promising the technique of stereotactic radiotherapy, which is often used in pancreatic cancer and permit achieving high local control. At our institution there has been developed and introduced into clinical practice a method of stereotactic radiotherapy for the palliative treatment of patients with pancreatic cancer, which improved not only the duration but also the quality of life of patients.
Assuntos
Cuidados Paliativos/métodos , Neoplasias Pancreáticas/cirurgia , Qualidade de Vida , Radiocirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Neoplasias Pancreáticas/diagnóstico por imagem , Análise de Sobrevida , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
Data on radio- and thermoradiotherapy of 83 patients with extra-abdominal desmoid tumors are discussed. In a group of 57 patients followed up for 10 years or less, the relapse-free survival rates, in thermoradiotherapy-treated cases, were significantly higher (74.4% and 28.6%) than in those receiving radiotherapy (9.3% and 57.1%). Monitoring tumor temperature during local hyperthermia is a factor of relapse-free survival of vital importance.
Assuntos
Fibromatose Agressiva/radioterapia , Hipertermia Induzida , Intervalo Livre de Doença , Seguimentos , Humanos , Radioterapia/métodos , Resultado do TratamentoAssuntos
Neoplasias da Mama/radioterapia , Cuidados Pós-Operatórios/métodos , Adulto , Idoso , Neoplasias da Mama/mortalidade , Neoplasias da Mama/patologia , Neoplasias da Mama/cirurgia , Feminino , Seguimentos , Humanos , Mastectomia Radical , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Dosagem Radioterapêutica , Radioterapia Adjuvante/métodos , Análise de Sobrevida , Fatores de Tempo , Resultado do TratamentoRESUMO
The authors developed a method of eccentric rotation therapy of the ribs by the Aspekt-I optimization program using for irradiation the Altai-MT gamma-apparatus with an automated control system. A mean fractionation regimen (5 fractions of 4 Gy daily) was used. An analgesic effect for 5-10 days was observed in all patients, a complete effect--1-1.5 mos. after treatment.