Structural Diversity, Spectral Data, and Pharmacological Effects of Genus Nigella.

Nigella is one of the most studied plants because of its pharmacological properties like anti-parasitic, anti-inflammatory, neuro-protective, hepatoprotective, and anti-cancerous. In this study, about 20 species of the genus Nigella were reviewed and among them, N. damascene, N. glandulifera, and N. sativa are widely studied for their phytochemical and pharmacological effects. This review describes the phytochemical composition of the genus Nigella, which constitutes many of the compounds including alkaloids, flavonoids, saponins, and terpenoids. The extracts produced by using different solvents and the isolated compounds displayed a wide range of biological activity. These compounds were identified by different spectral techniques. The spectral detail of some advanced techniques including EIS-MS, UV/VIS, IR, 13 C-NMR, and 1 H-NMR of some important phytoconstituents of Nigella spp. has been compiled for the first time in this review which will be helpful to explore and further investigate the chemical composition of this genus.

Effects of antibiotics on Vietnam koi, Anabas testudineus, exposed to Aeromonas dhakensis as a co-infection.

The dietary effects of antibiotics on aquatic disease is circumstantial and has not been investigated under infections. the efficacy of erythromycin, after 10 days in use and 10 days off, on the survival and infection rate of (Anabas testudineus) after co-infection with antibiotic-resistant Aeromonas dhakensis (isolate NV5M or V7L). The mortality rate observed in non-medicated groups of co-infected fish (93.3 and 100%) was significantly higher (p < 0.05) than that in the medicated group of naturally infected fish (NIF) (53.3%) but not significantly different to that in medicated groups of co-infected fish (66.6% and 86.6%). In particular, the loads of invasive erythromycin-resistant bacteria (ERB) were markedly higher (p < 0.05, 3.5-4.8 times) in the kidney of co-infected fish medicated for 5 days than those in NIF. The measure of ERB in the kidney of fish co-infected with isolate V7L, whether medicated or not for 10 days, was significantly higher (p < 0.05) than that in non-medicated NIF and also that in the medicated group of fish co-infected with isolate NV5M. In addition to the elevation of gut-derived ERB invasion and colonization in the kidney, synergistic effects of the competition between mixed pathogens caused by co-infection and medication might result in a high fish mortality rate. Further investigation of antibiograms and/or new strategies for aquatic disease control should be undertaken with mixed infections and interaction of pathogens to achieve the optimal treatment effect.