Separation of iron-52 from chromium cyclotron targets on the 2% cross-linked anion-exchange resin AG1-X2 in hydrochloric acid.

Iron-52 can be separated from solutions of chromium cyclotron targets by eluting chromium, copper and radioactive impurities with 9.0M hydrochloric acid from a column containing 1.0 g of AG1-X2 anion-exchange resin. Iron-52 is retained and can then be eluted with 6.0M hydrochloric acid containing 0.05M hydrogen iodide or 0.05M sodium iodide. The separations are sharp and quantitative. Less than 2 microg of chromium will remain with the iron-52, from 2.0 g originally present.

Separation of lead-203 from cyclotron-bombarded thallium targets by ion-exchange chromatography.

A simple method is presented for the separation of lead-203 from copper-backed thallium cyclotron targets. The procedure involves cation-exchange chromatography in hydrochloric acid and hydrochloric acid-acetone mixtures. Further purification involves anion-exchange chromatography in nitric acid-hydrobromic acid mixtures. A cation-exchange column containing 3.0 g of resin can handle as much as 15 g of thallium and 160 mg of copper. An anion-exchange column containing 3.0 g of resin can separate lead from up to 200 mg of thallium and 10 mg of copper. Separations are extremely sharp and less than 0.1 mug of thallium and less than 0.1 mug of copper remain in the lead-203 fraction.

Integral excitation functions for natKr + p up to 116 MeV and optimization of the production of 81Rb for (81m)Kr generators.

Effective cross-sections for the production of 79,81,81m,82m,83,84,84m,86Rb, (77,79,85m)Kr and 77,82Br in the bombardment of natKr with protons were measured from threshold up to 116 MeV. Thick-target production-rate curves based on the measured integral excitation functions were also derived for 81,82m,83,84,86Rb, and the optimum incident energy for the production of 81Rb/(81m)Kr, as a function of the target thickness in MeV, was determined. Geometry-dependent hybrid-model calculations performed by means of the computer code ALICE/85/300 were found to be in good agreement with the experimental results as well as the derived thick-target production-rate curves.

Evaluation of (o)-[77Br]bromohippuran as renal tubular function agent.

(o)-[77Br]bromohippuran (BHIP) was developed as renal tubular function agent due to its favourable chemical and physical properties and compared to (o)-[131I]iodohippuran (IHIP). Renograms obtained from baboons were compared and absorbed radiation dose calculations performed. Although BHIP showed a delayed kidney uptake and washout pattern, good kidney clearance of the radionuclide was obtained after 30 min. Radiation dose values for BHIP were markedly lower than for IHIP indicating that larger activities of BHIP could be administered to increase counting statistics. BHIP imaging in normal volunteers did however not substantiate the favourable behaviour obtained in the primate.