RESUMO
Chromosomal heteromorphism in constitutive heterochromatin of chromosomes 1, 9 and 16 was studied in 8 patients with cervix cancer and 15 patients with cervix dysplasia. Tissue cultures (diploid fibroblasts) established from tumor biopsies as well as lymphocyte cultures were used for making C-banded chromosome preparations. The heteromorphism in the appearance of C-bands was expressed as differences in band size or position (inversions). 5 of the cervix cancer patients and 8 of those with dysplasia showed heteromorphism in chromosome 1. In two cancer patients, tissue culture as well as blood cells were available for analysis and both showed the same pattern of heteromorphism, thus suggesting an inherited origin of the variability. Heterochromatin heteromorphism was more common in chromosome 1 than in chromosomes 9 and 16. The heteromorphism in constitutive heterochromatin of chromosome 1 might be among the factors that dispose to cancer.
Assuntos
Aberrações Cromossômicas , Cromossomos Humanos 1-3/ultraestrutura , Cromossomos Humanos 16-18/ultraestrutura , Cromossomos Humanos 6-12 e X/ultraestrutura , Heterocromatina/ultraestrutura , Displasia do Colo do Útero/genética , Neoplasias do Colo do Útero/genética , Adulto , Idoso , Células Cultivadas , Bandeamento Cromossômico , Feminino , Humanos , Linfócitos/ultraestrutura , Pessoa de Meia-Idade , Neoplasias do Colo do Útero/sangueRESUMO
A patient on oral contraceptives over several years developed unilateral proptosis, haemorrhagic retinopathy and increase in intraocular pressure. An orbital vein venogram confirmed the diagnosis of right superior ophthalmic vein thrombosis. There was complete resolution of thrombosis and eye signs and symptoms with discontinuation of the oral contraceptive.
Assuntos
Anticoncepcionais Orais/efeitos adversos , Órbita/irrigação sanguínea , Tromboflebite/induzido quimicamente , Adulto , Feminino , Humanos , Pressão Intraocular/efeitos dos fármacos , Flebografia , Tromboflebite/diagnóstico por imagem , Tomografia Computadorizada por Raios X , VeiasRESUMO
Acquired arteriovenous fistula is an unusual complication of lumbar disc surgery. Diagnosis is often late because of the lack of awareness of this complication and also because it may simulate other vascular diseases. A case diagnosed initially as deep vein thrombosis of the leg is described.
Assuntos
Fístula Arteriovenosa/diagnóstico , Vértebras Lombares/cirurgia , Complicações Pós-Operatórias/diagnóstico , Tromboflebite/diagnóstico , Adulto , Fístula Arteriovenosa/etiologia , Feminino , HumanosRESUMO
Between January 1982 and December 1989, 12 patients with 13 acute extradural haematomas as a result of injury involving the venous sinuses were treated by the first author. The CT scan appearances in 6 cases were remarkable in that there were large bubbles of low density in the hyperdense haematomas and liquid blood was found during the operation. The possible underlying pathophysiological changes that gave rise to this appearance are discussed. The CT scan appearance and the proximity of the clot to the venous sinuses should alert the neurosurgeon to the high probabilities of venous sinus tear such that proper treatment can be offered.