Detalhe da pesquisa
1.
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.
Cell
; 151(7): 1595-607, 2012 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23260145
2.
Transcription factor achaete scute-like 2 controls intestinal stem cell fate.
Cell
; 136(5): 903-12, 2009 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-19269367
3.
Synergistic activity of IDH1 inhibitor BAY1436032 with azacitidine in IDH1 mutant acute myeloid leukemia.
Haematologica
; 106(2): 565-573, 2021 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32241846
4.
Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis.
J Hepatol
; 72(4): 725-735, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31726117
5.
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.
Mol Cell
; 37(5): 607-19, 2010 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20227366
6.
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Nature
; 476(7360): 293-7, 2011 Jul 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21727895
7.
Identification of stem cells in small intestine and colon by marker gene Lgr5.
Nature
; 449(7165): 1003-7, 2007 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-17934449
8.
Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane.
Gastroenterology
; 141(4): 1371-80, 1380.e1-2, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21741923
9.
Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening.
SLAS Discov
; 26(8): 947-960, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34154424
10.
Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A.
J Med Chem
; 64(21): 15883-15911, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34699202
11.
Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer.
Cell Rep
; 36(3): 109394, 2021 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34289372
12.
Induction of protein tyrosine kinase 6 in mouse intestinal crypt epithelial cells promotes DNA damage-induced apoptosis.
Gastroenterology
; 137(3): 945-54, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19501589
13.
Wnt signaling, lgr5, and stem cells in the intestine and skin.
Am J Pathol
; 174(3): 715-21, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19197002
14.
SLC25A32 sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism.
Oncotarget
; 11(8): 801-812, 2020 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32166001
15.
Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target.
Cancers (Basel)
; 12(1)2020 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31947537
16.
Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine.
Mol Cell Biol
; 26(13): 4949-57, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16782882
17.
Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia.
J Hematol Oncol
; 12(1): 66, 2019 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31253180
18.
The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.
Leukemia
; 33(10): 2403-2415, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30940908
19.
Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5.
J Med Chem
; 62(2): 928-940, 2019 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30563338
20.
Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.
ACS Chem Biol
; 12(8): 1986-1992, 2017 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28679043