Detalhe da pesquisa
1.
Site-Selective Palladium-catalyzed Oxidation of Unprotected Aminoglycosides and Sugar Phosphates.
Chemistry
; 30(19): e202400017, 2024 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38284753
2.
Synthesis of 4-O-(4-Amino-4-deoxy-ß-D-xylopyranosyl)paromomycin and 4-S-(ß-D-Xylopyranosyl)-4-deoxy-4'-thio-paromomycin and Evaluation of their Antiribosomal and Antibacterial Activity.
Tetrahedron
; 1352023 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37035443
3.
Antimicrobial susceptibility patterns of respiratory Gram-negative bacterial isolates from COVID-19 patients in Switzerland.
Ann Clin Microbiol Antimicrob
; 20(1): 64, 2021 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34493302
4.
Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant.
J Am Chem Soc
; 142(1): 530-544, 2020 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31790244
5.
Predictive Analysis of the Side Chain Conformation of the Higher Carbon Sugars: Application to the Preorganization of the Aminoglycoside Ring 1 Side Chain for Binding to the Bacterial Ribosomal Decoding A Site.
J Org Chem
; 85(24): 16043-16059, 2020 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32902280
6.
Epidemiologic, Phenotypic, and Structural Characterization of Aminoglycoside-Resistance Gene aac(3)-IV.
Int J Mol Sci
; 21(17)2020 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32854436
7.
Molecular Mechanisms of Intrinsic Streptomycin Resistance in Mycobacterium abscessus.
Antimicrob Agents Chemother
; 62(1)2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29061744
8.
Experimental Determination of the pKa Values of Clinically Relevant Aminoglycoside Antibiotics: Toward Establishing pKa-Activity Relationships.
ACS Omega
; 9(5): 5876-5887, 2024 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38343924
9.
Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine blood stream infection models.
Int J Antimicrob Agents
; : 107181, 2024 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38653351
10.
Phenotypic and genotypic characterization of Neisseria gonorrhoeae isolates among individuals at high risk for sexually transmitted diseases in Zurich, Switzerland.
Int J STD AIDS
; 35(6): 462-470, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38297880
11.
Synthesis of Gentamicins C1, C2, and C2a and Antiribosomal and Antibacterial Activity of Gentamicins B1, C1, C1a, C2, C2a, C2b, and X2.
ACS Infect Dis
; 9(8): 1622-1633, 2023 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37481733
12.
Comparison of Disk Diffusion, E-Test, and Broth Microdilution Methods for Testing In Vitro Activity of Cefiderocol in Acinetobacter baumannii.
Antibiotics (Basel)
; 12(7)2023 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37508308
13.
Importance of Co-operative Hydrogen Bonding in the Apramycin-Ribosomal Decoding A-Site Interaction.
ChemMedChem
; 18(1): e202200486, 2023 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36198651
14.
Synthesis, Antibacterial and Antiribosomal Activity of the 3C-Aminoalkyl Modification in the Ribofuranosyl Ring of Apralogs (5-O-Ribofuranosyl Apramycins).
Antibiotics (Basel)
; 12(1)2022 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36671225
15.
Structure-Activity Relationships for 5'' Modifications of 4,5-Aminoglycoside Antibiotics.
ChemMedChem
; 17(13): e202200120, 2022 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35385605
16.
Apramycin susceptibility of multidrug-resistant Gram-negative blood culture isolates in five countries in Southeast Asia.
Int J Antimicrob Agents
; 60(4): 106659, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-35988665
17.
Synthesis and Antibacterial Activity of Propylamycin Derivatives Functionalized at the 5''- and Other Positions with a View to Overcoming Resistance Due to Aminoglycoside Modifying Enzymes.
ACS Infect Dis
; 7(8): 2413-2424, 2021 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34114793
18.
An Advanced Apralog with Increased inâ vitro and inâ vivo Activity toward Gram-negative Pathogens and Reduced ex vivo Cochleotoxicity.
ChemMedChem
; 16(2): 335-339, 2021 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33007139
19.
Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice.
Clin Microbiol Infect
; 27(9): 1315-1321, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-33316399
20.
Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis.
EBioMedicine
; 73: 103652, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34740109